Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice

Kukula, Osman; Kırmızıkan, Seda; Tiryaki, Emre Soner; Çiçekli, Mustafa Nusret; Günaydın, Caner

doi:10.1080/08923973.2022.2048849

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…Experimental studies performed in different animals models of wound healing, including phthalic anhydride (PA)-induced atopic dermatitis, excision, incision, burn and diabetic wounds models, have shown that the topical and oral administration of CAE reduces massive neutrophil recruitment accompanied by reducing release of TNF-α, IL-1β, IL-6, and IgE, and inhibition of the expression of iNOS, COX-2, NF-κB and lipoxygenase (LOX) activity in the site of skin injury [ 31 , 32 , 41 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. Recently, Kukula et al [ 53 ] showed that asiatic acid treatment (100 mg/kg, p.o) suppressed the imiquimod-induced increase in serum levels of IL-17A and IL-23 in the imiquimod-induced psoriasis model [ 53 ]. Studies have demonstrated that IL-23 induces the differentiation of naive CD4 + T cells into highly pathogenic helper T cells (Th17/ThIL-17) that produce IL-17, IL-17F, IL-6, and TNF-α [ 2 , 5 , 6 ].…”

Section: Centella Asiatica and Cutaneous Repair Processmentioning

confidence: 99%

“…Moreover, both CEA and asiatic acid display significant anti-inflammatory activity and consequence might be an important tool to diminish the exacerbated inflammation found in chronic wounds. As mentioned above, asiatic acid treatment (100 mg/kg, p.o) suppressed the imiquimod-induced increase in serum levels of IL-17A and IL-23, an important inflammatory pathway found in the pathogenesis of some chronic cutaneous diseases [ 53 ]. Paocharoen [ 49 ] reported that the treatment with CAE capsule, three times a day (50 mg of extracted asiaticosides), was effective in the wound healing promotion and also suppress the scar in diabetic wound patients ( Table 1 ).…”

Section: Centella Asiatica and Cutaneous Repair Processmentioning

confidence: 99%

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Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential

et al. 2023

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An intense effort has been focused on new therapeutic approaches and the development of technologies for more efficient and rapid wound healing. The research for plants used for long time in traditional medicine in the treatment of wound has become a promising strategy to obtain drugs therapeutically useful in the acute and chronic wound management. In this context, Centella asiatica (Apiaceae) has been used to treat a variety of skin diseases, such as leprosy, lupus, varicose ulcers, eczema and psoriasis, in Asiatic traditional medicine for thousands of years. Studies have shown that Centella asiatica extracts (CAE) display activity in tissue regeneration, cell migration and wound repair process by promoting fibroblast proliferation and collagen synthesis. Preliminary findings have shown that the asiatic acid is one of the main active constituents of C. asiatica, directly associated with its healing activity. Thus, this study discusses aspects of the effects of Centella asiatica and its active component, asiatic acid, in different stages of the healing process of cutaneous wounds, including phytochemical and antimicrobial aspects that contribute to its therapeutic potential.

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Section: Centella Asiatica and Cutaneous Repair Processmentioning

confidence: 99%

Section: Centella Asiatica and Cutaneous Repair Processmentioning

confidence: 99%

Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential

et al. 2023

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“…can, reduce mast cell infiltration and reduce levels of skin inflammation by inhibiting the secretion of inflammatory factors such as IL-23. 45,46 The tanshinone IIA in Salvia miltiorrhiza Bunge can inhibit keratinocyte proliferation, and induce apoptosis via the caspase pathway. 47 Nimbolide in Azadirachta indica A. Juss.…”

Section: Psoriasismentioning

confidence: 99%

Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

Liu¹,

Chen²,

Li³

et al. 2023

DDDT

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Background: Adaptogens are a class of medicinal plants that can nonspecifically enhance human resistance. Most of the plant adaptogens have relevant applications in dermatology, but there are still few studies related to their particular action and co-operative mechanisms in topical skin application. Methods: Plant adaptogens related articles and reviews that published between 1999 and 2022 were obtained from the Web of Science Core Collection database. Various bibliographic elements were collected, including the annual number of publications, countries/regions, and keywords. CiteSpace, a scientometric software, was used to conduct bibliometric analyses. Also, the patsnap global patent database was used to analyze the patent situation of plant adaptogens in the field of cosmetics up to 2021. Results: We found that the effects of plant adaptogens on skin diseases mainly involve atopic dermatitis, acne, allergic contact dermatitis, psoriasis, eczema, and androgenetic alopecia, etc. And the effects on skin health mainly involve anti-aging and antiphotoaging, anti-bacterial and anti-fungal, anti-inflammatory, whitening, and anti-hair loss, etc. Also, based on the results of patent analysis, it is found that the effects of plant adaptogens on skin mainly focus on aging retardation. The dermatological effects of plant adaptogens are mainly from Fabaceae Lindl., Araliaceae Juss. and Lamiaceae Martinov., and their mainly efficacy phytochemical components are terpenoids, phenolic compounds and flavonoids. Conclusion:The plant adaptogens can repair the skin barrier and maintain skin homeostasis by regulating the skin HPA-like axis, influencing the oxidative stress pathway to inhibit inflammation, and regulating the extracellular matrix (ECM) components to maintain a dynamic equilibrium, ultimately achieving the treatment of skin diseases and the maintenance of a healthy state.

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“…In addition, it has a wide range of biological activities, such as anti-inflammatory, antioxidant, anti-infective, and anti-tumor effects [ 8 ]. Intensive studies in the past decades have revealed that AA plays a crucial role in myocardial injury [ [9] , [10] , [11] ], hepatitis [ 12 , 13 ], osteoporosis [ 14 , 15 ], tumors [ [16] , [17] , [18] , [19] ], bacterial and fungal infection [ 20 , 21 ], skin diseases [ 22 , 23 ], wound healing [ 24 ], and diabetes [ 25 , 26 ]. Furthermore, it has great potential in treating various neurological diseases such as spinal cord injury (SCI), neural tumors, traumatic brain injury (TBI), epilepsy, cerebral ischemia, Alzheimer's disease (AD), and Parkinson's disease (PD).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective mechanisms of Asiatic acid

Ding

Liu

2023

Heliyon

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Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice

Cited by 6 publications

References 26 publications

Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential

Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential

Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

Neuroprotective mechanisms of Asiatic acid

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