Asiatic acid alleviates metabolism disorders in ob/ob mice: mechanistic insights

Niu, Kaixia; Bai, Pengpeng; Yang, Bingbing; Feng, Xinchi; Qiu, Feng

doi:10.1039/d2fo01069k

Cited by 11 publications

(8 citation statements)

References 45 publications

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“…Parabacteroides , norank_f__norank_o__Clostridia_UCG-014 , Prevotellaceae_UCG-004 , UCG-005 , and Prevotella were enriched in the Cel group (Figure D), consistent with a previous study Parabacteroides goldsteinii and Parabacteroides distasonis, the predominant species within the Parabacteroides , were found to be beneficial for alleviating obesity, metabolic dysfunctions, and improving intestinal integrity. , Clostridia_UCG-014 had the potential to ameliorate disorders in glucose and lipid metabolism, as well as to promote the production of propionate and butyrate .…”

Section: Resultssupporting

confidence: 90%

“…29,30 Clostri-dia_UCG-014 had the potential to ameliorate disorders in glucose and lipid metabolism, as well as to promote the production of propionate and butyrate. 31 Prevotellaceae_UCG-004 was shown to be related to efficient carbohydrate metabolism. 32 In addition, UCG-005 and Prevotella were also reported to be important SCFA-producing bacteria.…”

Section: Fermentation Characteristics Of Cellulose In Thementioning

confidence: 99%

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Molecular Mechanisms Underlying the Effects of Small Intestinal Fermentation on Enhancement of Prebiotic Characteristics of Cellulose in the Large Intestine

Bai,

Zhang,

Chao

et al. 2024

J. Agric. Food Chem.

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Knowledge about the prebiotic characteristics of cellulose by in vitro fermentation is not complete due to the neglect of small intestinal fermentation. This study investigated the effects of small intestinal fermentation on the prebiotic characteristics of cellulose in the large intestine and potential mechanisms through an approach of combined in vivo small intestinal fermentation and in vitro fermentation. The structural similarity between cellulose in feces and after processing by the approach of this study confirmed the validity of the approach employed. Results showed that small intestinal fermentation of cellulose increased both acetate and propionate content and enriched Corynebacterium selectively. Compared to in vitro fermentation after in vitro digestion of cellulose, the in vitro fermentation of cellulose after in vivo small intestinal fermentation produced higher contents of acetate and propionate as well as the abundance of probiotics like Ruminococcaceae_UCG-002, Blautia, and Bif idobaterium. The changes in the structural features of cellulose after in vivo small intestinal fermentation were more obvious than those after in vitro digestion, which may account for the greater production of short-chain fatty acids (SCFAs) and the abundance of probiotics. In summary, small intestinal fermentation enhanced the prebiotic characteristics of cellulose in the large intestine by predisrupting its structure.

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Section: Resultssupporting

confidence: 90%

Section: Fermentation Characteristics Of Cellulose In Thementioning

confidence: 99%

Molecular Mechanisms Underlying the Effects of Small Intestinal Fermentation on Enhancement of Prebiotic Characteristics of Cellulose in the Large Intestine

Bai,

Zhang,

Chao

et al. 2024

J. Agric. Food Chem.

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“…At genus levels, norank_f__Muribaculaceae 36) , Lactobacillus 37) , unclassified_f__Lachnospiraceae, norank_f__Lachnospiraceae 38) , Lachnospiraceae_ UCG-006 39) , Alistipes 40) , Streptococcus 41) , Rikenellaceae_ RC9_gut_group 42) , unclassified_f__Prevotellaceae 43) are SCFAs-producing bacteria, which are beneficial for liver health and are reported to be negatively associated with hepatic oxidative stress, inflammation and damage 44) . Norank_f__norank_o__Clostridia_UCG-014 45) , and Pre-votellaceae_UCG-001 46) are beneficial bacteria, that are reported to exert anti-inflammatory function and are inversely correlated with pro-inflammatory cytokines, like IL-6 and TNF-α. In this study, D-gal administration led to significantly declined relative abundance of norank_f__ Muribaculaceae, Lachnospiraceae_UCG-006, Streptococcus, and Alistipes, supporting the microbial dysbiosis in gut of D-gal-fed mice.…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin, <i>Haematococcus pluvialis</i> and <i>Haematococcus pluvialis</i> Residue Alleviate Liver Injury in D-Galactose-induced Aging Mice through Gut-liver Axis

Zhang,

Gao,

Zhu

et al. 2024

J. Oleo Sci.

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tive diseases, and liver diseases 1) . Liver is an important organ that is essential for maintaining whole-body metabolic homeostasis. The process of aging leads to gradual damage to the structure and function of liver 2) . One of the most accepted mechanisms underlying aging is oxidative Abstract: Astaxanthin is a keto-based carotenoid mainly obtained from marine organisms, like Haematococcus pluvialis (H. pluvialis). Previous studies indicated the protective effects of Astaxanthin and H. pluvialis on aging related oxidative injury in liver, while the potential mechanisms are largely unknown. In addition, H. pluvialis residue is a by-product after astaxanthin extraction, which is rarely studied and utilized. The present study aimed to compare the effects of astaxanthin, H. pluvialis and H. pluvialis residue on the oxidant injury of liver in D-galactose-induced aging mice and explore the potential mechanisms through gut-liver axis. The results showed that all the three supplements prevented D-galactose-induced tissue injury, oxidative stress and chronic inflammation in liver and improved liver function. Gut microbiota analysis indicated that astaxanthin notably increased fecal levels of Bacteroidetes, unclassified_f__ Lachnospiraceae, norank_f__Lachnospiraceae, norank_f__norank_o__Clostridia_UCG-014, Prevotellaceae_ UCG-001, unclassified_f__Prevotellaceae in D-galactose-fed mice (p < 0.05). Compared to aging mice, H. pluvialis group had higher fecal levels of norank_f__Lachnospiraceae and Lachnospiraceae_UCG-006 (p < 0.05). H. pluvialis residue group displayed higher relative levels of Bacteroidetes, Streptococcus, and Rikenellaceae_RC9_gut_group (p < 0.05). Moreover, the production of fecal microbial metabolites, like SCFAs and LPS was also differently restored by the three supplements. Overall, our results suggest astaxanthin, H. pluvialis and H. pluvialis residue could prevent aging related hepatic injury through gutliver axis and provide evidence for exploiting of H. pluvialis residue as a functional ingredient for the treatment of liver diseases. Future studies are needed to further clarify the effect and mechanism of dominant components of H. pluvialis residue on liver injury, which is expected to provide a reference for the high-value utilization of H. pluvialis resources.

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“…The probiotic genus Clostridia_UCG-014 is associated with tryptophan metabolism and inflammation. It has been shown to be beneficial in treating disorders of glucose and lipid metabolism ( Hu Q. et al, 2022 ; Niu et al, 2022 ). Clostridia_vadinBB60_group is positively correlated with inflammatory markers and negatively correlated with anti-inflammatory markers ( Sun J. et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

10-hydroxy-2-decenoic acid alleviates lipopolysaccharide-induced intestinal mucosal injury through anti-inflammatory, antioxidant, and gut microbiota modulation activities in chickens

Han,

Zhang,

et al. 2023

Front. Microbiol.

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IntroductionThis study aimed to investigated the effects of 10-hydroxy-2-decenoic acid (10-HDA) on the growth performance, intestinal barrier, inflammatory response, oxidative stress, and gut microbiota of chickens challenged with lipopolysaccharide (LPS).MethodsA total of 240 one-day-old chickens were randomly assigned to five treatment groups: (1) control group (basal diet + saline); (2) LPS group (basal diet + LPS); (3) Chlortetracycline (CTC) group (basal diet containing 75 mg/kg CTC + LPS); (4) 0.1% 10-HDA group (basal diet containing 1 g/kg 10-HDA + LPS); and (5) 0.5% 10-HDA group (basal diet containing 5 g/kg 10-HDA + LPS). All chickens were injected intraperitoneally with 0.5 mg/kg body weight of either LPS or saline at 17, 19, and 21 days of age.ResultsThe results showed that dietary 10-HDA supplementation attenuated the loss in growth performance caused by the LPS challenge (p < 0.05). 10-HDA effectively alleviated LPS-induced intestinal mucosal injury, as evidenced by reduced bleeding, decreased serum diamine oxidase levels (p < 0.05), and increased villus/crypt ratios of the jejunum and ileum (p < 0.05). Dietary treatment with 0.1% 10-HDA reduced the concentrations of inflammatory cytokines (TNF-α, IL-1β, IL-6; p < 0.05), and increased immunoglobulin (IgA, IgG) and antioxidant enzyme levels (CAT, GSH-px, T-SOD) in the serum of LPS-challenged chickens (p < 0.05). These effects were similar to those observed in the CTC group. Moreover, 0.1% 10-HDA treatment reversed the LPS-induced variations in the mRNA expression of genes related to inflammation, antioxidant capacity, and intestinal tight junctions (p < 0.05). 16S rRNA analysis revealed that 10-HDA supplementation increased the relative abundance of Faecalibacterium and Clostridia_UCG-014 (p < 0.05). Additionally, it decreased the abundance of Clostridia_vadinBB60_group, Eubacterium_nodatum_group, and UC5-1-2E3 (p < 0.05). These changes were correlated with reduced inflammation and improved antioxidant capacity in the LPS-challenged chickens.ConclusionCollectively, dietary 10-HDA supplementation alleviated LPS-induced intestinal mucosal injury and the loss of growth performance through anti-inflammatory, antioxidant, and gut microbiota modulation activities in chickens. Moreover, 0.1% 10-HDA supplementation had comparable or even better protection for LPS-challenged chickens than supplementation with antibiotics or 0.5% 10-HDA. 10-HDA has the potential to be used as an alternative to antibiotics in protecting the intestinal health and improving the performance of poultry.

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Asiatic acid alleviates metabolism disorders in ob/ob mice: mechanistic insights

Abstract: Glucolipid metabolism disorders pose a serious, global health problem and more effective prevention and treatment methods are urgently needed. In this study, ob/ob mice were used to explore the potential...

Cited by 11 publications

References 45 publications

Molecular Mechanisms Underlying the Effects of Small Intestinal Fermentation on Enhancement of Prebiotic Characteristics of Cellulose in the Large Intestine

Molecular Mechanisms Underlying the Effects of Small Intestinal Fermentation on Enhancement of Prebiotic Characteristics of Cellulose in the Large Intestine

Astaxanthin, <i>Haematococcus pluvialis</i> and <i>Haematococcus pluvialis</i> Residue Alleviate Liver Injury in D-Galactose-induced Aging Mice through Gut-liver Axis

10-hydroxy-2-decenoic acid alleviates lipopolysaccharide-induced intestinal mucosal injury through anti-inflammatory, antioxidant, and gut microbiota modulation activities in chickens

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