Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells

Lee, Yong Soo; Jin, Da-Qing; Kwon, Eun Jin; Park, Seunghee; Lee, Eung-Seok; Jeong, Tae Cheon; Nam, Doo Hyun; Huh, Keùn; Kim, Jung-Ae

doi:10.1016/s0304-3835(02)00260-4

Cited by 123 publications

(106 citation statements)

References 31 publications

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“…Asiatic acid, a pentacyclic triterpene isolated from the Brahmi plant, Centella asiatica, was successfully tested for its apoptotic effects in HepG2 cells. This triterpene decreased the viablility of HepG2 cells mediated by an increase in intracellular calcium levels, which led to the increase in expression of the tumor suppressor gene p53 [79] . BA, another pentacyclic triterpene, was significantly effective in inducing cytotoxicity in hepatoblastoma cell lines, namely HUH6, HepT1 and HepT3.…”

Section: Triterpenesmentioning

confidence: 97%

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Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Thoppil

Bishayee²

2011

WJH

265

134

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Despite significant advances in medicine, liver cancer, predominantly hepatocellular carcinoma remains a major cause of death in the United States as well as the rest of the world. As limited treatment options are currently available to patients with liver cancer, novel preventive control and effective therapeutic approaches are considered to be reasonable and decisive measures to combat this disease. Several naturally occurring dietary and non-dietary phytochemicals have shown enormous potential in the prevention and treatment of several cancers, especially those of the gastrointestinal tract. Terpenoids, the largest group of phytochemicals, traditionally used for medicinal purposes in India and China, are currently being explored as anticancer agents in clinical trials. Terpenoids (also called "isoprenoids") are secondary metabolites occurring in most organisms, particularly plants. More than 40 000 individual terpenoids are known to exist in nature with new compounds being discovered every year. A large number of terpenoids exhibit cytotoxicity against a variety of tumor cells and cancer preventive as well as anticancer efficacy in preclinical animal models. This review critically examines the potential role of naturally occurring terpenoids, from diverse origins, in the chemoprevention and treatment of liver tumors. Both in vitro and in vivo effects of these agents and related cellular and molecular mechanisms are highlighted. Potential challenges and future directions involved in the advancement of these promising natural compounds in the chemoprevention and therapy of human liver cancer are also discussed.

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Section: Triterpenesmentioning

confidence: 97%

“…; ↑p53 10-100 μmol/L Lee et al [79] Betulinic acid Displayed cytotoxicity against HUH6, HepT1 and HepT3 cells ↑apoptosis; ↑caspase 3; ↓PI3K/AKT; ↓GLI1; ↓PTCH1; ↓IGF2…”

Section: +mentioning

confidence: 99%

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Thoppil

Bishayee²

2011

WJH

265

134

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“…Acetyl-11-Keto-Β-Boswellic Acid (AKBA), the active ingredient of Boswellia serrata, acts as anti-angiogenic agents by inhibiting Vascular Endothelial Growth Factor (VEGF) signalling [106]. Asiatic acid, a pentacyclic triterpene present in Centella asiatica decreases viability of cancer cells by increasing expression of p53 [107].…”

Section: Modern Therapy Vs Herbal Therapymentioning

confidence: 99%

Need of an Ancient Roots to Modern Medicine in the Treatment of Cancer- A review

Gunjan

Naidu²,

Marzo³

et al. 2017

ijpm

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A b s t r a c tThe already available expensive conventional therapies for cancer like chemotherapy and radiotherapy have a number of side effects such as myelosuppression and neurological, cardiac, pulmonary, and renal toxicity, which pose serious harm to the quality of there is a need to develop treatment options that include more potent and less toxic anticancer drugs as compared to existing drugs. and vegetables because of phytochemical compounds ex activity of antioxidant and free radicals which in turn showing anti semi agents are primarily used in com treatment of a variety of cancers. VLB is used for the treatment of leukaemia, lymphomas, advanced testicular cancer, breast and lung cancers, and Kaposi's sarcoma, and VCR, in addition to the treat acute lymphocytic leukaemia in childhood. VRLB has shown activity against non lung cancer and advanced breast cancer. based, natural process in order to stop the growth of cancer cells. This approach can limit the damage to normal cells and the accompanying side effects caused by conventional chemot agents. drug development. The current findings and known anticancer agents from natural sources are discussed, and recent therapeutic advances in this field

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“…Its anti-cancer efficacy is attributed to its ability to inhibit transcription factor NF-jB, p38 MAP and ERK kinases in a variety of tumor cells [18][19][20][21]. AA induced apoptotic cell death in human hepatoma and malignant glioma cells through enhancing intracellular calcium release [22,23]. AA as well as C. asiatica extract have also been shown to inhibit HT-29 colon cancer cells in vitro and in azoxymethane-induced aberrant crypt formation and colon cancer in the intestines of F344 rats [24,25].…”

Section: Asiatic Acidmentioning

confidence: 99%

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

et al. 2012

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a b s t r a c tOver the last two decades, extensive research on plant-based medicinal compounds has revealed exciting and important pharmacological properties and activities of triterpenoids. Fruits, vegetables, cereals, pulses, herbs and medicinal plants are all considered to be biological sources of these triterpenoids, which have attracted great attention especially for their potent anti-inflammatory and anti-cancer activities. Published reports in the past have described the molecular mechanism(s) underlying the various biological activities of triterpenoids which range from inhibition of acute and chronic inflammation, inhibition of tumor cell proliferation, induction of apoptosis, suppression of angiogenesis and metastasis. However systematic analysis of various pharmacological properties of these important classes of compounds has not been done. In this review, we describe in detail the pre-clinical chemopreventive and therapeutic properties of selected triterpenoids that inhibit multiple intracellular signaling molecules and transcription factors involved in the initiation, progression and promotion of various cancers. Molecular targets modulated by these triterpenoids comprise, cytokines, chemokines, reactive oxygen intermediates, oncogenes, inflammatory enzymes such as COX-2, 5-LOX and MMPs, anti-apoptotic proteins, transcription factors such as NF-jB, STAT3, AP-1, CREB, and Nrf2 (nuclear factor erythroid 2-related factor) that regulate tumor cell proliferation, transformation, survival, invasion, angiogenesis, metastasis, chemoresistance and radioresistance. Finally, this review also analyzes the potential role of novel synthetic triterpenoids identified recently which mimic natural triterpenoids in physical and chemical properties and are moving rapidly from bench to bedside research.

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Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells

Cited by 123 publications

References 31 publications

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Need of an Ancient Roots to Modern Medicine in the Treatment of Cancer- A review

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

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