Asian sand dust enhances ovalbumin-induced eosinophil recruitment in the alveoli and airway of mice

Hiyoshi, Kyoko; Ichinose, Takamichi; Sadakane, Kaori; Takano, Hirohisa; Nishikawa, Masataka; Mori, Ikue; Yanagisawa, Rie; Yoshida, Seiichi; Kumagai, Yoshito; Tomura, Shigeo; Shibamoto, Takayuki

doi:10.1016/j.envres.2005.03.008

Cited by 69 publications

(53 citation statements)

References 32 publications

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“…Epidemiological studies have shown that Asian dust increases hospitalizations and emergency visits because it exacerbates asthma (Kanatani et al, 2010;Yang et al, 2005), allergic rhinitis (Chang et al, 2006) conjunctivitis (Yang, 2006) and contact dermatitis (Otani et al, 2012), and it decreases the peak expiratory flow values (Park et al, 2005;Watanabe et al, 2011). These findings are supported by some experiments with laboratory animals: Asian sand dust inhalation enhanced allergen-induced airway inflammation in mice and in guinea pigs (Hiyoshi et al, 2005;Ichinose et al, 2008;Lei et al, 2004) and allergic rhinitis in rats (Ichinose et al, 2009). …”

Section: Introductionsupporting

confidence: 72%

Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa

Higashi

Kambayashi

Ohkura

et al. 2014

Atmospheric Environment

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AbbreviationsTotal suspended particulate (TSP); Particulate matter (PM); Light detection and ranging (LIDAR); Polycyclic aromatic hydrocarbons (PAHs) 1 AbstractThe health effects associated with Asian dust have attracted attention due to the rapid increase in the number of Asian dust events in East Asia in recent years. The aim of this study was to investigate the associations between Asian dust and daily cough, as well as allergic symptoms, in adult patients who suffer from chronic cough. We enrolled 86 adult patients from Kanazawa University Hospital, Japan, who were diagnosed with asthma, cough variant asthma, atopic cough or a combination of these conditions. From January to June 2011, subjects recorded their symptoms in a diary every day. Asian dust and non-Asian dust periods were defined according to the dust extinction coefficient, measured using the light detection and ranging (LIDAR). The daily levels of total suspended particulates, polycyclic aromatic hydrocarbons (PAHs) and coexisting factors related to allergies, such as the Japanese cedar pollen count, were measured.McNemar's test showed that there were significantly more cough-positive patients during Asian dust periods than during the non-Asian dust period (p = 0.022). In addition, during Asian dust periods when the daily levels of Japanese cedar pollen, Japanese cypress pollen and PAHs were elevated, there were significantly more patients who experienced itchy eyes than during the non-Asian dust period (p < 0.05). On the other hand, there were no significant differences in the allergic symptoms, including sneezing or a runny nose and nasal congestion. This is the first report to show that Asian dust triggers cough and allergic symptoms in adult patients with chronic cough.

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Section: Introductionsupporting

confidence: 72%

Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa

Higashi

Kambayashi

Ohkura

et al. 2014

Atmospheric Environment

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“…Previous studies on the acute pulmonary toxicity caused by intratracheally instilled ASD demonstrated that the mineralogical components of ASD particles, free from chemical and biological pollutants, caused acute inflammatory changes in lung tissues (Naota et al 2010). It has also been reported that ASD particles enhanced eosinophilic lung inflammation induced by ovalbumin (Hiyoshi et al 2005;Ichinose Yoshida, Hiyoshi, et al 2008;Ichinose, Yoshida, Sadakane, et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Pathological Study of Chronic Pulmonary Toxicity Induced by Intratracheally Instilled Asian Sand Dust (Kosa)

et al. 2012

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Asian sand dust (ASD) events are associated with an increase in pulmonary morbidity and mortality. The number of ASD events has increased rapidly in the east Asian region since 2000. To study the chronic lung toxicity of ASD, saline suspensions of low doses (200 and 400 mg) and high doses (800 and 3,000 mg) of ASD were intratracheally instilled into ICR mice. Animals were sacrificed at 24 hr, 1 week, or 1, 2, or 3 months after instillation. Histopathological examination revealed that ASD induced acute inflammation at 24 hr after instillation. The acute inflammation was transient and subsided at 1 week and 1 month after instillation. At 2 and 3 months after instillation, focal infiltration of lymphocytes with accumulation of epithelioid macrophages, which is a suggestive finding of transformation to granuloma, and granuloma formation were occasionally observed. Aggregation of macrophages containing particles was observed in the pulmonary lymph nodes at 3 months after instillation in high-dose groups. Prolonged inflammatory foci (granuloma) and presence of ASD particles in pulmonary lymph nodes would have a chance to induce immunological modulation leading to adverse health effects in the exposed animals.

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“…We previously reported that exposure of adult mice to microparticles, including urban particulate matter and carbon black particles, caused neutrophil infiltration in lung tissue as well as marked increase in the number of eosinophils in BALF related to administration of OVA. 17,21) In the present study, we compared lung histology in groups of mice exposed in utero to UPM (UPM group, UPM+ OVA group) with that in the respective control groups (untreated group, OVA group) and found marked infiltration of inflammatory cells such as eosinophils in the submucosa of the airway in the UPM+ OVA group. This suggests that inflammation is caused by fetal exposure to UPM in the absence of direct inhalation and that this process continues after birth.…”

Section: Discussionmentioning

confidence: 99%

“…OVA was dissolved in the same saline as the particles, and the instillation dose was set at 1 µg/mouse according to a previous report. 17) Four intratracheal instillations of OVA at 2-week intervals are needed to induce allergic lung inflammation. 18) Therefore, this method was chosen to investigate the aggravating effect of fetal exposure to UPM on allergen-related lung eosinophilia.…”

Section: Methodsmentioning

confidence: 99%

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Effects of Fetal Exposure to Urban Particulate Matter on the Immune System of Male Mouse Offspring

Yoshida

Takano

Nishikawa

et al. 2012

Biological & Pharmaceutical Bulletin

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Urban particulate matter (UPM) has been shown to have an aggravating effect on Th2-associated immune systems in adult mice. However, the effects of fetal exposure to UPM on immune response in offspring have not been elucidated. In the present study, we administered UPM (200 µg/animal) by intratracheal injection to pregnant dams on days 7 and 14 of gestation. Subsequently, 9-and 24-week-old male offspring were intratracheally injected with ovalbumin (OVA) (four times at 2-week intervals) to create a mouse model of bronchial asthma. We then evaluated the progression of allergic manifestations in the offspring through histological findings, the number of inflammatory cells in bronchoalveolar lavage fluid (BALF), and protein concentration of cytokines and chemokines in BALF 5, 10, 15, and 30 weeks after birth. Histological examination showed that fetal exposure to UPM alone caused slight eosinophil and lymphocyte infiltration in the submucosa of the airway and bronchial epithelium and significant increases in the number of macrophages. Moreover, postnatal intratracheal administration of OVA to offspring exposed to UPM in utero caused significant increases in the numbers of macrophages, eosinophils, and lymphocytes and in the concentrations of their relevant cytokines and chemokines, showing that fetal exposure to UPM aggravated the chemically sensitized immune system of male offspring.

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Asian sand dust enhances ovalbumin-induced eosinophil recruitment in the alveoli and airway of mice

Cited by 69 publications

References 32 publications

Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa

Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa

Pathological Study of Chronic Pulmonary Toxicity Induced by Intratracheally Instilled Asian Sand Dust (Kosa)

Effects of Fetal Exposure to Urban Particulate Matter on the Immune System of Male Mouse Offspring

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