Asian sand dust aggravates allergic rhinitis in guinea pigs induced by Japanese cedar pollen

Abstract

Asian sand dust (ASD) contains microbial materials, sulfate (SO(4)(2-)), and nitrate (NO(3)(-)), and is derived from air pollutants in East China. ASD reportedly causes adverse respiratory health effects; a case in point is aggravated allergen-associated experimental lung eosinophilia. Guinea pigs were administered normal saline (control), ASD (0.3 mg/animal), ASD (0.6 mg/animal), Japanese cedar pollen (JCP) (0.2 mg/kg body weight), JCP + ASD (0.3 mg/animal), or JCP + ASD (0.6 mg/animal), into their nasal cavities at seven weekly intervals. The number of sneezes, amount of nasal secretions, and nasal obstructing response were measured as indices of nasal responses. Total immunoglobulin E (IgE) antibodies in serum and the number of eosinophils, histamine, and arachidonic acid metabolites in nasal cavity lavage fluids (NCLF) were also measured. ASD enhanced the JCP-associated nasal obstructing response, but not the number of sneezes or amount of nasal secretions. ASD enhanced JCP-associated cysteinyl leukotrienes (C(4), D(4), E(4)) and histamine production in NCLF. ASD augmented the number of eosinophils in NCLF and total IgE in serum induced by JCP. ASD enhanced eosinophil recruitment in the nasal mucosa, and goblet cell proliferation in the nasal epithelium induced by JCP. These results suggest that ASD enhances the nasal allergic reaction induced by repeated JCP administration in guinea pigs.

Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa

“…Epidemiological studies have shown that Asian dust increases hospitalizations and emergency visits because it exacerbates asthma (Kanatani et al, 2010;Yang et al, 2005), allergic rhinitis (Chang et al, 2006) conjunctivitis (Yang, 2006) and contact dermatitis (Otani et al, 2012), and it decreases the peak expiratory flow values (Park et al, 2005;Watanabe et al, 2011). These findings are supported by some experiments with laboratory animals: Asian sand dust inhalation enhanced allergen-induced airway inflammation in mice and in guinea pigs (Hiyoshi et al, 2005;Ichinose et al, 2008;Lei et al, 2004) and allergic rhinitis in rats (Ichinose et al, 2009). …”

A Systematic Review of Global Desert Dust and Associated Human Health Effects

“…Wantanabe [85] reported that 11%-22% of patients with asthma experienced worsening of lower respiratory tract symptoms on dust storm days. Some studies noted that pollen could augment the influence of desert dust on the morbidity of asthma and rhinitis [86][87][88].…”

Aggravation of Allergic Rhinitis by Air Pollution: Demonstration by an Animal Model of Pollenosis

“…Ichinose et al (2008b) first reported that exposure to Asian sand dust to OVA-sensitized mice enhanced allergen challenge-induced asthmatic responses including lung eosinophilia, Th2 cytokine and chemokine production in the lungs. More interestingly, they (Ichinose, 2009). However, the relationship between Asian sand dust and health problems remains inconclusive, and further epidemiological and experimental studies are required.…”