Asian ethnicity in anonymous oocyte donors is associated with increased estradiol levels but comparable recipient pregnancy rates compared with Caucasians

Impact of GnRH agonist triggering and intensive luteal steroid support on live-birth rates and ovarian hyperstimulation syndrome: a retrospective cohort study

“…That it reflects LH activity rather than peak E2 would also potentially be consistent with the lack of association between peak oestradiol and pregnancy rates in the present study, however in our population pre-trigger endogenous LH on the day of the trigger did not differ among those women having peak E2 ≥ 4,000 pg/mL and those with peak E2 < 4,000 pg/mL. This indicates that the suggested threshold of 4,000 pg/mL may not apply to the Asian population, consistent with previous reports suggesting that women of Asian origin have higher E2 for a given number of oocytes as compared to non- Asian women [29,30]. When the live-birth rates were stratified per peak E2 quartiles in the subgroup with a peak E2 ≥ 4,000 pg/mL, no differences were observed, further strengthening that peak E2 may not play a critical role in obtaining a live-birth rate after GnRHa trigger and intensive luteal support.…”

Racial disparities in in vitro fertilization outcomes

“…Elevated E 2 levels created by stimulation might negatively affect endometrial receptivity. This hypothesis was supported by Fujimoto et al, who showed that Asian recipients of donor oocytes who avoided exposure to ovarian stimulation protocols and resultant high E 2 levels, had similar pregnancy rates to white women (16). A future study could evaluate the impact of autologous freeze-all cycles with subsequent frozen embryo transfers in Asian women as a means of improving pregnancy rates by potentially enhancing endometrial receptivity.…”

Ethnic variation in estradiol metabolism in reproductive age Asian and white women treated with transdermal estradiol

“…We first reported that Asians achieve higher E 2 levels during gonadotropin stimulation compared with whites in autologous oocyte IVF cycles (7) and replicated the finding in a study of oocyte donors (8). Although the mechanism for the observed difference is not known, ethnic differences in biosynthesis or metabolic clearance remain possibilities.…”