Asian and non‐Asian disparities in outcomes of non‐nasopharyngeal head and neck cancer

Kim, Jason D.; Chang, Jennifer; Moghaddamjou, Ali; Kornelsen, Emily; Ruan, Jenny Y.; Olson, Robert; Cheung, Winson Y.

doi:10.1002/lary.26603

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…Asian populations have been shown to have improved overall survival for nasopharyngeal cancer compared to white patients . Similarly, for non‐nasopharyngeal head and neck cancer, despite presenting with worse prognostic features and receiving less aggressive treatment, Asians have improved overall survival compared to non‐Asians …”

Section: Discussionmentioning

confidence: 99%

Disparities in sinonasal squamous cell carcinoma short‐ and long‐term outcomes: Analysis from the national cancer database

Carey¹,

Parasher

Workman³

et al. 2017

The Laryngoscope

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Section: Discussionmentioning

confidence: 99%

Disparities in sinonasal squamous cell carcinoma short‐ and long‐term outcomes: Analysis from the national cancer database

Carey¹,

Parasher

Workman³

et al. 2017

The Laryngoscope

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“…Given that actomyosin contractility‐driven forces have previously been implicated in modulating nuclear deformations, [ 16 ] we inquired if the diminished contractile forces exerted by the KO cells are manifested in modified nuclear compression. Using confocal microscopy, we measured the nucleus thickness for both KO and WT cells as reported by us earlier.…”

Section: Resultsmentioning

confidence: 99%

Actin Filaments Couple the Protrusive Tips to the Nucleus through the I‐BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers

et al. 2023

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The cell migration cycle, well-established in 2D, proceeds with forming new protrusive structures at the cell membrane and subsequent redistribution of contractile machinery. Three-dimensional (3D) environments are complex and composed of 1D fibers, and 1D fibers are shown to recapitulate essential features of 3D migration. However, the establishment of protrusive activity at the cell membrane and contractility in 1D fibrous environments remains partially understood. Here the role of membrane curvature regulator IRSp53 is examined as a coupler between actin filaments and plasma membrane during cell migration on single, suspended 1D fibers. IRSp53 depletion reduced cell-length spanning actin stress fibers that originate from the cell periphery, protrusive activity, and contractility, leading to uncoupling of the nucleus from cellular movements. A theoretical model capable of predicting the observed transition of IRSp53-depleted cells from rapid stick-slip migration to smooth and slower migration due to reduced actin polymerization at the cell edges is developed, which is verified by direct measurements of retrograde actin flow using speckle microscopy. Overall, it is found that IRSp53 mediates actin recruitment at the cellular tips leading to the establishment of cell-length spanning fibers, thus demonstrating a unique role of IRSp53 in controlling cell migration in 3D.

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“…Grouping patients into 2 cohorts for race makes it difficult to draw conclusions about the racial minority individuals for whom public health intervention is most critical. Literature on HNC has shown differences in disease presentation and survival by race, and there are several differences in the health care experience of a patient by race that cannot be accounted for . There is an opportunity for future studies to verify these initial results with a larger data set that fully accounts for race and ethnicity and additional variables.…”

Section: Discussionmentioning

confidence: 99%

Differences in Receipt of Immunotherapy Treatment Among Patients With Head and Neck Cancer

Ramkumar,

Bhardwaj,

Patel

et al. 2023

JAMA Otolaryngol Head Neck Surg

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ImportanceThe US Food and Drug Administration approved immune checkpoint inhibitors (immunotherapy) for select cases of head and neck squamous cell carcinoma (HNSCC) in 2016. However, it is unclear whether there are clinical or sociodemographic differences among patients receiving immunotherapy as part of their care. Given the known disparities in head and neck cancer care, we hypothesized that there are differences in receipt of immunotherapy among patients with HNSCC based on clinical and nonclinical characteristics.ObjectiveTo characterize clinical and nonclinical factors associated with receipt of immunotherapy among older patients with HNSCC.Design, Setting, and ParticipantsThis retrospective cohort study included patients 65 years or older diagnosed with HNSCC (n = 4860) in a community oncology care setting. Electronic health records from Navigating Cancer were assessed from January 1, 2017, to April 30, 2022.Main Outcomes and MeasuresMultivariable logistic regression was used to characterize clinical (tumor stage [localized vs advanced] and anatomical subsite [oropharyngeal vs nonoropharyngeal]) and nonclinical (age, smoking history, race and ethnicity, sex, and marital status) factors associated with receipt of immunotherapy.ResultsIn the study cohort of 4860 patients, 3593 (73.9%) were men; 4230 (87.0%) were White and 630 (13.0%) were of other races. A total of 552 patients (11.4%) had received immunotherapy. After adjusting for covariates, in the final model, White patients with HNSCC had 80% increased odds of receiving immunotherapy (adjusted odds ratio [AOR], 1.80 [95% CI, 1.30-2.48]) compared with patients of other races. There were no statistically significant differences in the odds of receiving immunotherapy based on age, sex, or smoking history. Patients with nonoropharyngeal disease were significantly more likely to receive immunotherapy than those with oropharyngeal cancer (AOR, 1.29 [95% CI, 1.05-1.59]), as were those with advanced compared with local disease (AOR, 2.39 [95% CI, 1.71-3.34]).Conclusions and RelevanceThe findings of this cohort study suggest that among older patients with HNSCC, White patients may be more likely to receive immunotherapy as part of their care. Equitable access to immunotherapy and other treatment options will reduce cancer-related health disparities and improve survival of patients with HNSCC.

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Asian and non‐Asian disparities in outcomes of non‐nasopharyngeal head and neck cancer

Abstract: 2c. Laryngoscope, 127:2528-2533, 2017.

Cited by 6 publications

References 36 publications

Disparities in sinonasal squamous cell carcinoma short‐ and long‐term outcomes: Analysis from the national cancer database

Disparities in sinonasal squamous cell carcinoma short‐ and long‐term outcomes: Analysis from the national cancer database

Actin Filaments Couple the Protrusive Tips to the Nucleus through the I‐BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers

Differences in Receipt of Immunotherapy Treatment Among Patients With Head and Neck Cancer

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