ASHP therapeutic position statement on the institutional use of 0.9% sodium chloride injection to maintain patency of peripheral indwelling intermittent infusion devices

Intravascular device use, management, documentation and complications: a point prevalence survey

“…Both flushing and locking of devices are important to prevent clot formation inside the catheter. If these processes are not carried out, cannula patency may be lost, and removal and resiting of the device may be necessary (16) .…”

Heparinized Saline Solution vs. Saline Solution (0.9% Sodium Chloride) for the Maintenance of Dorsal Pedal Arterial Catheter Patency in Dogs Undergoing General Anesthesia: A Pilot Study

“…Elimination of risks of heparin-associated side effects is important for patient safety in human medicine. The guideline by Benner et al (8) and a case study by Passannate et al (7) sound the alarm on these heparin-related complications in human medicine. However, to the best of our knowledge, there are currently no studies reporting heparin-associated complications including bleeding, alternation of aPTT, and drug hypersensitivity in dogs given a continuous HS infusion during direct arterial blood pressure measurement.…”

“…In contrast, Everson et al reported that HS is more effective at preventing occlusion compared to SS (6). Furthermore, heparin exposure can result in complications such as bleeding, alternation of activated partial thromboplastin time (aPTT), and drug hypersensitivity in human patients (7,8).…”