Aseptic meningitis: Diagnosis and management

Abstract

The term aseptic meningitis encompasses all types of inflammations of the brain meninges other than that caused by pus producing organisms. It is usually a benign illness. Etiology of aseptic meningitis is very wide and includes many infections - both viral and non viral, drugs, malignancy and systemic illness. The most common cause is viral infection and enteroviruses - Coxsackie and ECHO viruses account for more than half of all cases. Clinical manifestations include headache, fever, malaise, photophobia and meningeal signs. Convulsions, neurological deficits and severe obtundation are rare except with certain non viral infectious meningitis. Diagnostic work up includes blood and cerebrospinal fluid (CSF) examination and serology for infectious meningitis. The polymerase chain reaction is a rapid and accurate method for detection of microbial DNA in CSF. Treatment is mainly supportive, except for the nonviral infectious etiology.

10.5937/mckg48-4030 = Development of aseptic meningitis after administration of amoxicillin

“…Aseptični meningitis obično je benigni sindrom i obuhvata sve tipove zapaljenja moždanih meningea koji nisu uzrokovani stvaranjem gnoja pod uticajem mikroorganizama (5). Ima veoma širok spektar etioloških uzročnika infektivne i neinfektivne prirode.…”

“…Nekoliko grupa lekova češće izaziva aseptični meningitis od drugih: nesteroidni antiinflamatorni lekovi (NSAIL), antimikrobna sredstva, intravenski imunoglobulini, CD3 monoklonska antitela, vakcine, lekovi za intratekalnu primenu i drugi (8). Antibiotici koji su do sada indukovali aseptični meningitis jesu: trimetoprim-sulfametoksazol, ciprofloksacin, cefalosporini, metronidazol, amoksicilin, penicilin, izoniazid i pirazinamid (5,(8)(9)(10)(11)(12)(13)(14). Dosad su najčešće prijavljivana neželjena dejstva za amoksicilin i klavulansku kiselinu: dijareja, nauzeja i osip na koži (15).…”

Laboratory Parameters of Cerebrospinal Fluid in Individuals With Enterovirus Meningitis: A Descriptive Study

“…Aseptic meningitis may or may not have a viral infection as the most common cause of the disease 3,5,13 .…”

“…These infections can present high morbidity and low mortality rates. They rarely lead to serious DOI: http://dx.doi.org/10.7322/jhgd.103022 complications, which are observed mainly in immuno-compromised individuals 1,3,7 .…”

“…They are single-stranded RNA viruses belonging to the Picornaviridae family. There are more than 100 serotypes, including poliovirus, A and B coxsackievirus, and echovirus 3,5,8,9,10,11 .…”