Aseptic Loosening of Orthopedic Implants : Osteoclastogenesis Regulation and Potential Therapeutics

Amirhosseini, Mehdi

doi:10.3384/diss.diva-154926

Cited by 1 publication

(1 citation statement)

References 148 publications

(172 reference statements)

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“…Obviously, titanium's mechanical strength is multiple times higher than any biological material, including bone-its density is up to 1200 kg/m 3 [138][139][140], its MOE varies from 10-3000 MPa, and its MOR is 150-180 MPa. [141,142] This significant disparity in mechanical properties allows stable fixation for fractures, but can also cause complications such as aseptic loosening [143][144][145][146][147][148].…”

Section: Mechanical Properties Of Wood As Bone Implant Compared With ...mentioning

confidence: 99%

Wood as Possible Renewable Material for Bone Implants—Literature Review

Nefjodovs

Andze

Andžs

et al. 2023

JFB

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Bone fractures and bone defects affect millions of people every year. Metal implants for bone fracture fixation and autologous bone for defect reconstruction are used extensively in treatment of these pathologies. Simultaneously, alternative, sustainable, and biocompatible materials are being researched to improve existing practice. Wood as a biomaterial for bone repair has not been considered until the last 50 years. Even nowadays there is not much research on solid wood as a biomaterial in bone implants. A few species of wood have been investigated. Different techniques of wood preparation have been proposed. Simple pre-treatments such as boiling in water or preheating of ash, birch and juniper woods have been used initially. Later researchers have tried using carbonized wood and wood derived cellulose scaffold. Manufacturing implants from carbonized wood and cellulose requires more extensive wood processing—heat above 800 °C and chemicals to extract cellulose. Carbonized wood and cellulose scaffolds can be combined with other materials, such as silicon carbide, hydroxyapatite, and bioactive glass to improve biocompatibility and mechanical durability. Throughout the publications wood implants have provided good biocompatibility and osteoconductivity thanks to wood’s porous structure.

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