Asenapine-Induced Restless Legs Syndrome: Differentiation from Akathisia

McCall, W. Vaughn; Riley, Mary Anne; Hodges, Chelsea; McCloud, Laryssa; Phillips, Molly; Rosenquist, Peter B.

doi:10.5664/jcsm.4296

Cited by 6 publications

(2 citation statements)

References 6 publications

(7 reference statements)

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“…Tables 1, 2, and 3 provide a collection of published case reports and case series of DI-RLS in the literature. From these case reports, antipsychotics (Table 1), 7-31 antidepressants (Table 2), 32-50 and antiepileptics (Table 3) 51-54 were the most common classes of medications suspected of causing RLS. In most cases, once the dose was reduced or the drug discontinued, the RLS symptoms resolved.…”

Section: Literature Searchmentioning

confidence: 99%

Drug-Induced Restless Legs Syndrome

Patatanian

Claborn

2018

Ann Pharmacother

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Section: Literature Searchmentioning

confidence: 99%

Drug-Induced Restless Legs Syndrome

Patatanian

Claborn

2018

Ann Pharmacother

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“…The connection between psychotropic drugs and iron has been previously documented as iron deficiency anemia, restless leg syndrome, tardive dyskinesia, akathisia, and neuroleptic malignant syndrome were associated with iron dysmetabolism ( 86 – 89 ). Moreover, low iron levels were linked to the negative symptoms of schizophrenia, while the offspring of hypoferremic mothers were found to be at risk of developing this disorder ( 90 ).…”

Section: Psychotropic Drugs and Obesitymentioning

confidence: 99%

The Other Obesity Epidemic—Of Drugs and Bugs

et al. 2020

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Chronic psychiatric patients with schizophrenia and related disorders are frequently treatment-resistant and may require higher doses of psychotropic drugs to remain stable. Prolonged exposure to these agents increases the risk of weight gain and cardiometabolic disorders, leading to poorer outcomes and higher medical cost. It is well-established that obesity has reached epidemic proportions throughout the world, however it is less known that its rates are two to three times higher in mentally ill patients compared to the general population. Psychotropic drugs have emerged as a major cause of weight gain, pointing to an urgent need for novel interventions to attenuate this unintended consequence. Recently, the gut microbial community has been linked to psychotropic drugs-induced obesity as these agents were found to possess antimicrobial properties and trigger intestinal dysbiosis, depleting Bacteroidetes phylum. Since germ-free animals exposed to psychotropics have not demonstrated weight gain, altered commensal flora composition is believed to be necessary and sufficient to induce dysmetabolism. Conversely, not only do psychotropics disrupt the composition of gut microbiota but the later alter the metabolism of the former. Here we review the role of gut bacterial community in psychotropic drugs metabolism and dysbiosis. We discuss potential biomarkers reflecting the status of Bacteroidetes phylum and take a closer look at nutritional interventions, fecal microbiota transplantation, and transcranial magnetic stimulation, strategies that may lower obesity rates in chronic psychiatric patients.

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Managing Concurrent Medications

Sharon

2017

Restless Legs Syndrome/Willis Ekbom Disease

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Asenapine-Induced Restless Legs Syndrome: Differentiation from Akathisia

Cited by 6 publications

References 6 publications

Drug-Induced Restless Legs Syndrome

Drug-Induced Restless Legs Syndrome

The Other Obesity Epidemic—Of Drugs and Bugs

Managing Concurrent Medications

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