Ascorbic acid versus magnesium for the prevention of atrial fibrillation after coronary artery bypass grafting surgery

Ebade, Abdelhay; Taha, Walid S; Saleh, Riham Hussein; Fawzy, Ashraf

doi:10.4103/1687-9090.143259

Cited by 9 publications

(19 citation statements)

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“…Finally, we perused the reference lists of the selected trials and relevant reviews, from which we discovered two more trials. We identified nine trials satisfying our selection criteria [11][12][13][14][15][16][17][18][19]. We did not include two further trials that reported "ventilator-free days" since we were unable to convert this to our outcome of interest, "duration of mechanical ventilation" [20,21].…”

Section: Methodsmentioning

confidence: 99%

“…Thus, we The searches were carried out on 13 Nov 2019. The searches identified nine trials that we included in our systematic review analysis [11][12][13][14][15][16][17][18][19] and eight of them were included in our meta-analysis [11][12][13][14][15][16][17][18] calculated that the average dose was 90 g/day in the Tanaka trial. Zabet et al administered 25 mg/kg every 6 h, but the mean weight was not reported [18].…”

Section: Methodsmentioning

confidence: 99%

“…Safaei et al [15] and Tanaka et al [17] administered vitamin C on a single day only, six trials administered for 2-5 days [11-13, 16, 18, 19], and one administered "until ICU discharge" for septic shock patients [14]. There is a 250-fold variation in the average length of mechanical ventilation in the untreated groups from 2 h [16] to 511 h [17], which reflects great variation in the severity of the baseline medical condition (Table 1).…”

Section: Description Of the Included Trialsmentioning

confidence: 99%

“…Six trials were randomized [11-13, 15, 18, 19], two used alternative allocation [14,17], and one did not describe the allocation method [16]. The reported baseline variables for the treatment groups were balanced in all trials (Additional file 1: Table S1).…”

Section: Description Of the Included Trialsmentioning

confidence: 99%

“…2. Four trials used an explicit placebo [11,16,18,19]. The trial by Sadeghpour et al [19] had a high dropout rate, with 500 participants recruited, but results were reported for just 290 participants [1].…”

Section: Description Of the Included Trialsmentioning

confidence: 99%

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Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis

2020

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Background: Our recent meta-analysis indicated that vitamin C may shorten the length of ICU stay and the duration of mechanical ventilation. Here we analyze modification of the vitamin C effect on ventilation time, by the control group ventilation time (which we used as a proxy for severity of disease in the patients of each trial). Methods: We searched MEDLINE, Scopus, and the Cochrane Central Register of Controlled Trials and reference lists of relevant publications. We included controlled trials in which the administration of vitamin C was the only difference between the study groups. We did not limit our search to randomized trials and did not require placebo control. We included all doses and all durations of vitamin C administration. One author extracted study characteristics and outcomes from the trial reports and entered the data in a spreadsheet. Both authors checked the data entered against the original reports. We used meta-regression to examine whether the vitamin C effect on ventilation time depends on the duration of ventilation in the control group.Results: We identified nine potentially eligible trials, eight of which were included in the meta-analysis. We pooled the results of the eight trials, including 685 patients in total, and found that vitamin C shortened the length of mechanical ventilation on average by 14% (P = 0.00001). However, there was significant heterogeneity in the effect of vitamin C between the trials. Heterogeneity was fully explained by the ventilation time in the untreated control group. Vitamin C was most beneficial for patients with the longest ventilation, corresponding to the most severely ill patients. In five trials including 471 patients requiring ventilation for over 10 h, a dosage of 1-6 g/day of vitamin C shortened ventilation time on average by 25% (P < 0.0001). Conclusions: We found strong evidence that vitamin C shortens the duration of mechanical ventilation, but the magnitude of the effect seems to depend on the duration of ventilation in the untreated control group. The level of baseline illness severity should be considered in further research. Different doses should be compared directly in future trials.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Description Of the Included Trialsmentioning

confidence: 99%

Section: Description Of the Included Trialsmentioning

confidence: 99%

Section: Description Of the Included Trialsmentioning

confidence: 99%

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Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis

2020

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Vitamin C supplementation in the critically ill: A systematic review and meta-analysis

Zhang

Jativa

2018

SAGE Open Medicine

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Background:Low plasma levels of vitamin C are associated with adverse outcomes, including increased mortality, in critically ill patients. Several trials have suggested that the administration of intravenous vitamin C in this setting may have beneficial effects, such as reducing the incidence of organ failure and improving survival. However, these studies have generally involved combination therapies consisting of vitamin C along with other antioxidants, confounding the effects of vitamin C alone. The primary objective of this meta-analysis is to investigate the effects of isolated intravenous supplementation of vitamin C in adults with critical illness.Methods:A database search was conducted for studies on the use of intravenous vitamin C in adult patients with critical illness. The primary outcome assessed was mortality at the longest follow-up time available. Secondary outcomes were the duration of mechanical ventilation, duration of vasopressor support, fluid requirements, and urine output in the first 24 h of intensive care unit admission.Results:Five studies (four randomized controlled trials and one retrospective review) enrolling a total of 142 patients were included in this meta-analysis. Compared with controls, the administration of intravenous vitamin C was associated with a decreased need for vasopressor support (standardized mean difference −0.71; 95% confidence interval (−1.16 to −0.26); p = 0.002) and decreased duration of mechanical ventilation (standardized mean difference −0.5; 95% confidence interval (−0.93 to −0.06); p = 0.03), but no difference was found in mortality (odds ratio 0.76; 95% confidence interval (0.27 to 2.16); p = 0.6). Trends were also noted toward decreased fluid requirements and increased urine output. No adverse effects were reported.Conclusion:The administration of intravenous vitamin C may lead to vasopressor sparing effects and a reduced need for mechanical ventilation in the critically ill, without affecting overall mortality. However, these results should be interpreted in light of the limitations of the primary literature and should serve as a preview of upcoming trials in this area.

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Μεταβολισμός Και Μοριακές Μεταβολές Του Κολπικού Μυοκαρδίου Προ Και Μετά Εξωσωματική Κυκλοφορία

Πολυμερὀπουλος¹

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Η κολπική μαρμαρυγή αποτελεί την συχνότερη μετεγχειρητική επιπλοκή ασθενών που υποβάλλονται σε καρδιοχειρουργικές επεμβάσεις με εξωσωματική κυκλοφορία. Σκοπός της παρούσας μελέτης ήταν να ερευνηθεί η δυνατότητα μείωσης της επίπτωσης της κολπικής μαρμαρυγής σε ασθενείς που υποβάλλονται σε καρδιοχειρουργική επέμβαση με εξωσωματική κυκλοφορία, με την χορήγηση χορήγηση βιταμίνης C και L-καρνιτίνης. Για τον σκοπό αυτό διενεργήθηκε μία προοπτική, τυχαιοποιημένη, διπλά τυφλή μελέτη. Η χορήγηση βιταμίνης C αποδείχθηκε αποτελεσματική και ασφαλής για την πρόληψη της μετεγχειρητικής κολπικής μαρμαρυγής. Στους κόλπους ασθενών που εμφανίζουν μετεγχειρητική κολπική μαρμαρυγή έχουμε αλλαγή στον λόγο του κολλαγόνου Ι προς το κολλαγόνο ΙΙΙ, με επικράτηση του κολλαγόνου Ι. Το κολλαγόνο ΧΙ αποτελεί πυρήνα επέκτασης των ινιδίων του κολλαγόνου Ι και ΙΙΙ, καθορίζοντας το μήκος και την διάταξη των ινιδίων αυτών. Σκοπός της παρούσας μελέτης, ήταν να διερευνήσει τη συμμετοχή των κολλαγόνων τύπου ΧΙ στην αρρυθμιογένεση της κολπικής μαρμαρυγής και να ταυτοποιήσει τα επίπεδα έκφρασης του mRNA και των αντίστοιχων πρωτεϊνών των κολλαγόνων τύπου XI σε ασθενείς με μετεγχειρητική κολπική μαρμαρυγή σε σύγκριση με ασθενείς που δεν εμφανίζουν κολπική μαρμαρυγή. Από τα αποτελέσματά μας δεν διαπιστώθηκε σημαντική διαφορά μεταξύ των δυο ομάδων.

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Ascorbic acid versus magnesium for the prevention of atrial fibrillation after coronary artery bypass grafting surgery

Cited by 9 publications

References 0 publications

Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis

Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis

Vitamin C supplementation in the critically ill: A systematic review and meta-analysis

Μεταβολισμός Και Μοριακές Μεταβολές Του Κολπικού Μυοκαρδίου Προ Και Μετά Εξωσωματική Κυκλοφορία

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