Ascorbic acid supplementation could affect passive avoidance learning and memory in rat

Shahidi, Siamak; Komaki‬, Alireza; Mahmoodi, Minoo; Atrvash, Nazanin; Ghodrati, Marzieh

doi:10.1016/j.brainresbull.2008.01.003

Cited by 61 publications

(37 citation statements)

References 27 publications

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“…This task was designed to test immediate short-term memory, stemming from concentration as opposed to actual learning (5). Two more recent studies addressed the antioxidant role of vitamin C in learning and memory (374,422). It was demonstrated that although acute injections of ascorbate had no effect on the learning ability of rats measured with passive avoidance test, short-and long-term supplementation with vitamin C facilitated acquisition and retrieval of learning and memory in rats (374).…”

Section: Ascorbate (Vitamin C)mentioning

confidence: 99%

“…Two more recent studies addressed the antioxidant role of vitamin C in learning and memory (374,422). It was demonstrated that although acute injections of ascorbate had no effect on the learning ability of rats measured with passive avoidance test, short-and long-term supplementation with vitamin C facilitated acquisition and retrieval of learning and memory in rats (374). Tveden-Nyborg et al went a step further and investigated the effect of chronic vitamin C deficiency on spatial memory as measured by the Morris water maze and also counted hippocampal neurons to assess whether ascorbate had an effect on neurodegeneration (422).…”

Section: Ascorbate (Vitamin C)mentioning

confidence: 99%

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Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad

Klann

2011

Antioxidants & Redox Signaling

468

350

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The brain is a metabolically active organ exhibiting high oxygen consumption and robust production of reactive oxygen species (ROS). The large amounts of ROS are kept in check by an elaborate network of antioxidants, which sometimes fail and lead to neuronal oxidative stress. Thus, ROS are typically categorized as neurotoxic molecules and typically exert their detrimental effects via oxidation of essential macromolecules such as enzymes and cytoskeletal proteins. Most importantly, excessive ROS are associated with decreased performance in cognitive function. However, at physiological concentrations, ROS are involved in functional changes necessary for synaptic plasticity and hence, for normal cognitive function. The fine line of role reversal of ROS from good molecules to bad molecules is far from being fully understood. This review focuses on identifying the multiple sources of ROS in the mammalian nervous system and on presenting evidence for the critical and essential role of ROS in synaptic plasticity and memory. The review also shows that the inability to restrain either age-or pathology-related increases in ROS levels leads to opposite, detrimental effects that are involved in impairments in synaptic plasticity and memory function.

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Section: Ascorbate (Vitamin C)mentioning

confidence: 99%

Section: Ascorbate (Vitamin C)mentioning

confidence: 99%

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad

Klann

2011

Antioxidants & Redox Signaling

468

350

View full text Add to dashboard Cite

show abstract

“…Similarly, Arz, et al, (2004) reported that oral supplementation of vitamin C could attenuate the risk of dementia in aged mice. Shahidi et al (2008) showed that intraperitoneal (i.p) administration of vitamin C could improve learning and memory in intact rats. Two different studies also showed that i.p.…”

Section: Discussionmentioning

confidence: 99%

Recognition Memory Impairment and The Role of DMSO, ALA and Vitamin C During Traumatic Brain Injury in albino rats

Bulama¹,

Bilbis²,

Abbas³

et al. 2017

JNBS

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“…Acute and chronic administration of PTW in animals has transiently produced several deficits in learning acquisition and short-term memory that are considered to be characteristic of cholinergic deficits in Alzheimer disease [8]. The well-replicated amnesic effect of PTW has been interpreted as a principal consequence of the blockade of post-synaptic muscarinic M1 transmission, leading to disruption in the functioning of the hippocampus in working memory.…”

Section: Discussionmentioning

confidence: 99%

Effect of Scutellaria Baicalensis on Scopolamine-Induced Memory and Cognitive Impairment in Rats

Go¹,

Jeong²,

Choi³

2014

IJBBB

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Abstract-Many studies have shown that the steamed root of Polygala tenuifolia (PTW) is effective for improving memory. The purpose of this study is to examine whether PTW extracts improved memory defects caused by β-amyloid (AMY) in the rats. The effects of PTW on the acetylcholinergic system in the hippocampus were also investigated. Male rats were administered daily of PTW. We conducted the Morris water maze (MWM) test as behavioral assessments. Changes in cholinergic system reactivity were also examined by measuring the immunoreactive neurons of acetylcholinesterase (AChE) in the hippocampus. Daily administration of PTW reduced the escape latency for finding the platform in the MWM. The administration of PTW significantly alleviated memory-associated decreases. The results demonstrated that PTW had a significants neuroprotective effect caused by β-amyloid in rats. These results suggest that PTW may be useful for improving cognitive functioning by stimulating cholinergic enzyme activities and alleviating inflammatory responses.

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Ascorbic acid supplementation could affect passive avoidance learning and memory in rat

Cited by 61 publications

References 27 publications

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Recognition Memory Impairment and The Role of DMSO, ALA and Vitamin C During Traumatic Brain Injury in albino rats

Effect of Scutellaria Baicalensis on Scopolamine-Induced Memory and Cognitive Impairment in Rats

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