Ascorbic acid metabolism in diabetes mellitus

Som, Suman; Basu, Soumik; Mukherjee, Debosree; Deb, Sanjukta; Choudhury, Panna; Mukherjee, Sourav; Chatterjee, Subhankar; Chatterjee, Indu B.

doi:10.1016/0026-0495(81)90133-5

Cited by 185 publications

(71 citation statements)

References 19 publications

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“…Numerous reports have found decreased levels of AA in diabetics (21)(22)(23)(24)(25), and similar results were obtained in the present study. Also, numerous cases showing reduced AA concentration inside the cells of diabetics with a high blood glucose level have been reported (22,(26)(27)(28)(29)(30).…”

Section: Resultssupporting

confidence: 92%

Decrease of Serum Ascorbic Acid Concentrations in Patients with Diabetic Macroangiopathy.

Nagano

Kurokawa

Ebara

et al. 1996

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe relationship between serum ascorbic acid (AA) and diabetic macroangiopathy was studied. Fifty-six patients with non insulin-dependent diabetes mellitus were examined, together with 20 healthy controls matched for age against the diabetes patients. Aortic pulse wave velocity (PWV) was taken as an index of the severity of ather osclerosis. The level of serum AA in diabetic patients was significantly lower than that of the controls. Among the diabetic groups, those with elevated PWV levels by age demonstrated a significant drop in AA. No significant differences were seen in the level of serum dehydroascrobic acid (DHAA) between patients and controls, nor were there any signifi cant differences among patient groups. The concentration of serum AA was inversely related to the risk factors of atherosclerosis, such as body mass index, Apo B/Apo A-I ratio, thiobarbituric acid-reactive substances (TBARS), and microalbumin in urine. It was inferred from these findings that the depletion of serum AA was apparent in diabetics with advanced atherosclerosis.

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Section: Resultssupporting

confidence: 92%

Decrease of Serum Ascorbic Acid Concentrations in Patients with Diabetic Macroangiopathy.

Nagano

Kurokawa

Ebara

et al. 1996

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…This has been observed in several diabetic populations (Yue et al, 1989;Som et al, 1981;Stankova et al, 1984) and appears to be a result of altered vitamin C metabolism in diabetes rather than reduced dietary intake (Sinclair et al, 1995). There is epidemiological evidence that low ascorbic acid intake and low plasma Vit C levels were associated with increased risk for mixed and cortical cataracts which may be seen in diabetic subjects (Leske et al, 1991).…”

Section: Ascorbic Acidmentioning

confidence: 92%

Recommendations for the nutritional management of patients with diabetes mellitus

Lean

1998

Eur J Clin Nutr

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“…Uptake of glucose and dehydroascorbic acid into some cells seems to be impaired in the diabetic and this may also extend to uptake of ascorbic acid (Chen et al 1983;Davis et al 1983;Kapeghian & Verlangieri, 1984;Stankova et al 1984;McLennan et al 1988). Reports published some years ago also suggested that there was indeed accumulation of dehydroascorbic acid in plasma (Chatterjee et al 1975;Chatterjee & Banerjee, 1979;Som et al 1981;Banerjee, 1982). Unfortunately, there is reason to believe that technical problems have made these earlier studies unsound and more recent work has been unable to confirm these increases in dehydroascorbic acid (Newill et al 1984;Stankova et al 1984;Sinclair et al 1991).…”

Section: Impact Of Disease On Transport Of Vitamin Cmentioning

confidence: 99%

The transport of vitamin C and effects of disease

Schorah

1992

Proc. Nutr. Soc.

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It has been known for a number of years that high concentrations of vitamin C (ascorbic acid + dehydroascorbic acid) occur in some cells, but it is only recently that we have begun to discover how high the levels are and also that the vitamin seems to be secreted onto epithelial surfaces (Table 1). If we assume that such concentrations and secretions are needed for the appropriate biological activity of the vitamin, it follows that transport of vitamin C will be required in order to sustain normal metabolic functions. Further, if transport is central to the metabolism of vitamin C, any defect in the process could lead to the development of disease.

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Ascorbic acid metabolism in diabetes mellitus

Cited by 185 publications

References 19 publications

Decrease of Serum Ascorbic Acid Concentrations in Patients with Diabetic Macroangiopathy.

Decrease of Serum Ascorbic Acid Concentrations in Patients with Diabetic Macroangiopathy.

Recommendations for the nutritional management of patients with diabetes mellitus

The transport of vitamin C and effects of disease

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