Ascorbic acid inhibits ROS production, NF-?B activation and prevents ethanol-induced growth retardation and microencephaly

Peng, Ying; Kwok, KH; Yang, Pai-Hao; Ng, Sophia; Liu, Jie; Wong, Oscar Gee‐Wan; He, Ming; Kung, Hsiang‐Fu; Lin, Marie C.M.

doi:10.1016/j.neuropharm.2004.10.018

Cited by 111 publications

(91 citation statements)

References 28 publications

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“…Hydrogen peroxide (H 2 O 2 ), one of the reactive oxygen species, plays an important role in many physiological phenomena such as senescence, photorespiration and photosynthesis, growth and development, and resistance responses against pathogens (Noctor and Foyer, 1998;Foreman and Tang, 2003;Peng et al, 2005). In addition, H 2 O 2 is generated as a primary messenger to induce hypersensitive cell death in the plant host.…”

mentioning

confidence: 99%

Virus-Induced Necrosis Is a Consequence of Direct Protein-Protein Interaction between a Viral RNA-Silencing Suppressor and a Host Catalase

et al. 2011

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Many plant host factors are known to interact with viral proteins during pathogenesis, but how a plant virus induces a specific disease symptom still needs further research. A lily strain of Cucumber mosaic virus (CMV-HL) can induce discrete necrotic spots on infected Arabidopsis (Arabidopsis thaliana) plants; other CMV strains can induce similar spots, but they are not as distinct as those induced by CMV-HL. The CMV 2b protein (2b), a known RNA-silencing suppressor, is involved in viral movement and symptom induction. Using in situ proximity ligation assay immunostaining and the protoplast assays, we report here that CMV 2b interacts directly with Catalase3 (CAT3) in infected tissues, a key enzyme in the breakdown of toxic hydrogen peroxide. Interestingly, CAT3, normally localized in the cytoplasm (glyoxysome), was recruited to the nucleus by an interaction between 2b and CAT3. Although overexpression of CAT3 in transgenic plants decreased the accumulation of CMV and delayed viral symptom development to some extent, 2b seems to neutralize the cellular catalase contributing to the host defense response, thus favoring viral infection. Our results thus provide evidence that, in addition to altering the type of symptom by disturbing microRNA pathways, 2b can directly bind to a host factor that is important in scavenging cellular hydrogen peroxide and thus interfere specifically with that host factor, leading to the induction of a specific necrosis.Cucumber mosaic virus (CMV) belongs to the genus Cucumovirus and contains tripartite, single-stranded sense RNAs designated RNA1 to RNA3 in decreasing order of molecular mass. RNA1 and RNA2 encode replicase proteins 1a and 2a, respectively, and RNA3 encodes the movement protein 3a. A subgenomic RNA,

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confidence: 99%

Virus-Induced Necrosis Is a Consequence of Direct Protein-Protein Interaction between a Viral RNA-Silencing Suppressor and a Host Catalase

et al. 2011

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“…Ascorbic acid also protects the neurons against exitotoxic cell death [30,31]. Vitamin C exerts neuroprotective action through scavenging the oxygen free radicals [58]. A decrease in lipid peroxidation, an increase catalase activities in the hippocampus were the reason for its neuroprotection [59].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of Ascorbic acid and Ginkgo biloba against Fluoride caused Neurotoxicity

Jetti¹,

Raghuveer²,

C³

et al. 2014

IOSRJESTFT

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“…(Figure 2.) Increased lipid peroxidation has been reported in preeclampsia, IUGR (Liu et al, 2005;Gupta et al, 2004, Bretelle et al, 2004. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is an important enzyme that generates superoxide anion radical localized in the placenta syncytial microvillous membrane (Matsubara & Sato, 2001;Raijmakers et al, 2004).…”

Section: Oxidative Agentsmentioning

confidence: 96%

“…Prolonged ethanol exposure lead to increased production of lipid peroxides and decreased expression of antioxidant enzymes. Ascorbic acid can prevent against ethanol toxicity through inhibition of ROS formation and NF-kB activation (Peng et al,2005). Zebrafish embryos exposed to ethanol with lipoic acid and/or only partially attenuated ethanol embryo toxicity, suggesting that other mechanisms are also involved (Reimers et al, 2006).…”

Section: The Role Of Oxidative Stress In Embryo and Fetal Malformationmentioning

confidence: 99%

The Role of Oxidative Stress in Female Reproduction and Pregnancy

Lázár¹

2012

Oxidative Stress and Diseases

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Ascorbic acid inhibits ROS production, NF-?B activation and prevents ethanol-induced growth retardation and microencephaly

Cited by 111 publications

References 28 publications

Virus-Induced Necrosis Is a Consequence of Direct Protein-Protein Interaction between a Viral RNA-Silencing Suppressor and a Host Catalase

Virus-Induced Necrosis Is a Consequence of Direct Protein-Protein Interaction between a Viral RNA-Silencing Suppressor and a Host Catalase

Neuroprotective effect of Ascorbic acid and Ginkgo biloba against Fluoride caused Neurotoxicity

The Role of Oxidative Stress in Female Reproduction and Pregnancy

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