Ascorbic acid and α-tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats

Effect of low-energy laser irradiation and antioxidant supplementation on cell apoptosis during skeletal muscle post-injury regeneration in pigs

“…The anti-apoptotic activity of α-tocopherol has been confirmed in several studies (Haendeler et al 1996, Ramanathan et al 2005, Guney et al 2007). The protective effect of vitamin E on cell death is the result of its free radical scavenging property, membrane stabilizing action and regulation of the expression of the number of genes and signal regulatory pathways (Allen andTresini 2000, Ramanathan et al 2005).…”

“…The protective effect of vitamin E on cell death is the result of its free radical scavenging property, membrane stabilizing action and regulation of the expression of the number of genes and signal regulatory pathways (Allen andTresini 2000, Ramanathan et al 2005). Consequently, this antioxidant can protect and stabilize mitochondrial membrane permeability, and block subsequent release of cytochrome c and caspase activation and finally cell death (Ramanathan et al 2005). Vitamin E can also reduce the level of tumor necrosis factor-α (TNF-α), primarily produced by activated macrophages, involved in the activation of external apoptosis pathway.…”

“…Vitamin E can also reduce the level of tumor necrosis factor-α (TNF-α), primarily produced by activated macrophages, involved in the activation of external apoptosis pathway. Furthermore, the anti-apototic activity of vitamin E is also connected with increasing the function of the anti-apoptotic Bcl-2 protein (Haendeler et al 1996, Ramanathan et al 2005. Due to the fact that the main anti-apoptotic action of α-tocopherol is connected with membrane stabilization and cell protection against oxidative stress-induced apoptosis, and macrophages are the main source of superoxide radicals and hydrolytic enzymes during muscle regeneration, macrophages seem to be the most apoptosis-protected population, which was confirmed in our results.…”

Sodium Arsenite-Induced Alteration in Hepatocyte Function of Rat with Special Emphasis on Superoxide Dismutase Expression Pathway and its Prevention by Mushroom Lectin

“…Here, we noted that the mushroom lectin and the ascorbic acidtreated group showed increased cell proliferation index and prevented arsenic-induced cytotoxicity. Ascorbic acid, a standard antioxidant, normalizes cell proliferation index through interaction with the oxidizing radicals and protects the cells from ROS [16]. Mushroom lectin also protects the cell against free radical-mediated damage through scavenging the radicals before their interaction with the cellular components [7].…”

L-Ascorbic acid and α-Tocopherol to protect against arsenic trioxide induced oxidative stress in H9c2 cardiomyocytes

“…[11] L-Ascorbic acid (L-AA) or Vitamin C, a low molecular weight, water-soluble antioxidant vitamin, possesses pro oxidant properties that helps the body's own free radical defense mechanism and destroy tumors in their initial stages. Evidences showed that ascorbic acid can improve mitochondrial function by improving the thiol status; thereby preventing reactive oxygen species -mediated damage.…”