Ascorbic Acid and Performance: A Review

Quadros, Luciana de

doi:10.4172/2376-1318.1000136

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Historically, both animal and human studies have shown mixed evidence towards performance enhancement with high dose vitamin C supplementation, with some studies leaning towards increased parameters of performance (3,24) and others displaying performance diminution (7,(25)(26)(27). Other meta-analyses and review articles have consistently concluded that there is some evidence of reduced oxidative stress with vitamin C supplementation, however this does not translate into improved performance, decreased muscle soreness or enhanced recovery (1,(28)(29)(30)(31). Finally, studies have demonstrated the importance of ROS in signaling pathways for muscular adaptation to training and, consequentially, how high dosages of antioxidants may interrupt this pathway (6,17,21).…”

Section: Discussionmentioning

confidence: 99%

Vitamin C Supplementation and Athletic Performance: A Review

Rogers

Lawlor

Moeller

2023

Curr Sports Med Rep

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Many athletes utilize high-dose vitamin C supplementation to optimize athletic performance. A review of research over the past 10 years on the use of vitamin C and athletic performance show mixed results. Fourteen randomized control trials were reviewed. In most studies, vitamin C was used with at least one additional supplement, usually vitamin E. Three studies showed positive outcomes associated with decreased markers of muscle damage after intense exercise with some form of vitamin C supplementation. The remaining 11 articles showed either neutral or negative effects of high dose vitamin C supplementation on muscle damage, physical performance, perceived muscle soreness, and/or adaptations to training. Based on a lack of consistent data and potential for blunted physiologic adaptations to training, long-term high-dosage supplementation with vitamin C is not recommended. Athletes should obtain antioxidants through a nutrient-rich diet instead of through supplement use.

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Section: Discussionmentioning

confidence: 99%

Vitamin C Supplementation and Athletic Performance: A Review

Rogers

Lawlor

Moeller

2023

Curr Sports Med Rep

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“…This could be due to the antioxidant supplementation [ 23 ]. Vitamin C is a potent reducing agent, due to its facility in donating electrons, and has an important antioxidant property [ 24 ]. Vitamin C intake significantly blunted the post-exercise high plasma MDA level as it reduces the production of ROS and oxidative stress inflicted by exercise-induced muscle damage.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Vitamin C Intake on Muscle Damage in Male Adolescents Performing Strenuous Physical Activity

Gabrial¹,

Shakib²,

Gabrial³

2018

Open Access Maced J Med Sci

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BACKGROUND:Strenuous non-regular exercise increases reactive oxygen species ROS level leading to an impaired balance between the endogenous antioxidant defence system and the free radicals production. Antioxidants intake can detoxify the peroxides produced during exercise, attenuating the inflammatory responses and therefore may prevent exercise-induced muscle damage.AIM:The purpose of this study was to determine the role of vitamin C intake in attenuating markers of muscle damage, oxidative stress and inflammatory responses in male adolescents performing the non-regular strenuous exercise.MATERIAL AND METHODS:Twenty recreationally active male adolescents were assigned to participate in the study. Eligible subjects performed strenuous recreational exercise (2-3 times per week) were randomly divided into two groups: The vitamin C (VC) group that consumed 500 mg of capsulated vitamin C after breakfast for a period of 90 days and the placebo (PL) group that consumed identical capsules in form and aspect that contained 500 mg of maltodextrin for the same period. Aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH) were assessed for muscle damage. Malondialdehyde (MDA) was evaluated as a marker of lipid peroxidation. Plasma creatinine, uric acid and urea were determined to monitor kidney function. C-reactive protein, a marker of systemic inflammation was also measured.RESULTS:In comparison between PL and VC groups, the plasma concentrations of muscle damage markers, oxidative stress markers, kidney function and inflammatory markers showed no significant difference in their baseline values (P > 0.05). The plasma concentrations of CK, LDH, MDA, urea, uric acid and CRP were significantly decreased in the VC group (P < 0.05) as compared to their values before the intake of vitamin C.CONCLUSION:The present results support the intake of vitamin C as an antioxidant for attenuating exercise-induced muscle damage, oxidative stress and inflammatory markers in male adolescents performing the strenuous physical activity.

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“…As an effect of now no longer taking nutrition C thru diet, a deficiency state happens which manifests with a huge spectrum of medical manifestations [1]. It is required for the manufacture of carnitine, collagen, neurotransmitters, and peptide hormones, as well as various other activities in the human body, such as hydroxylation and the oxidative catabolism of aromatic acids [2][3][4][5][6]. Ascorbic acid is a reducing agent because it is an electron donor.…”

Section: Introductionmentioning

confidence: 99%

A new spectrofluorimetric method for the determination of ascorbic acid with bromocresol purple in pharmaceutical samples

et al. 2021

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Based on the interaction between ascorbic acid and bromocresol purple, a new simple, straightforward, and quick method for the quantification of ascorbic acid is proposed. The procedure is based on the determined quenching effect of ascorbic acid on the natural fluorescence signal of bromocresol purple in the reaction between ascorbic acid and bromocresol purple in phosphate buffer solution (pH 6). The reduction of bromocresol purple fluorescence intensity is detected at 641 nm, while excitation occurs at 318 nm. The linear relationship between the reduced fluorescence intensity of bromocresol purple and the concentration of ascorbic acid is in the range 4.65 × 10–5 to 4.65 × 10–6 mol L−1 (R2 = 0.9964), with the detection limit of 8.77 × 10–7 mol L−1 and quantification limit of 2.35 × 10–5 mol L−1. The findings in this study further show that the new method provides good precision and repeatability, as well as satisfactory recovery values in terms of accuracy. The new method is tested on fifteen samples with different amounts of ascorbic acid and additional components. The effects of interfering components such as citrus bioflavonoids, citric acid, folic acid, paracetamol, calcium, and magnesium carbonate on the intensity of fluorescence of bromocresol purple are also investigated. The effects of interfering components such as citrus bioflavonoids (routine and hesperidin), citric acid, folic acid, paracetamol, calcium, and magnesium carbonate on the intensity of fluorescence of bromocresol purple are also investigated. The results of iodometric titration point out that the new method is effective for the determination of ascorbic acid in pharmaceutical samples. Article Highlights A new spectrofluorimetric method for determination of ascorbic acid in pharmaceutical samples using bromocresol purple. Determination of optimal parameters for ascorbic acid determination in a variety of pharmaceutical samples. Examination of the influence of additional substances in the pharmaceutical samples on the analysis.

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Ascorbic Acid and Performance: A Review

Cited by 5 publications

References 23 publications

Vitamin C Supplementation and Athletic Performance: A Review

Vitamin C Supplementation and Athletic Performance: A Review

Protective Role of Vitamin C Intake on Muscle Damage in Male Adolescents Performing Strenuous Physical Activity

A new spectrofluorimetric method for the determination of ascorbic acid with bromocresol purple in pharmaceutical samples

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