Ascorbic Acid and Acclimatization to Cold Environment

Dugal, L. P.; Therien, M

doi:10.1139/cjr47e-011

Cited by 28 publications

(5 citation statements)

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“…In theory, this concept could explain several experimental observations. First, it may be responsible for the apparent depletion of ascorbic acid within the adrenal gland following ACTH treatment or conditions of stress (27,51). Second, in young chickens it has been shown that vitamin C administered in doses of 1000 mg per kg of body weight ameliorated the immunosuppressive effects of exogenous cortisol and high environmental temperatures, in addition to reducing the mortality rates associated with such stress (99).…”

Section: Ascorbic Acid and Cortisolmentioning

confidence: 99%

Vitamin C: Effects of Exercise and Requirements with Training

Peake¹

2003

International Journal of Sport Nutrition and Exercise Metabolism

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Ascorbic acid or vitamin C is involved in a number of biochemical pathways that are important to exercise metabolism and the health of exercising individuals. This review reports the results of studies investigating the requirement for vitamin C with exercise on the basis of dietary vitamin C intakes, the response to supplementation and alterations in plasma, serum, and leukocyte ascorbic acid concentration following both acute exercise and regular training. The possible physiological significance of changes in ascorbic acid with exercise is also addressed. Exercise generally causes a transient increase in circulating ascorbic acid in the hours following exercise, but a decline below pre-exercise levels occurs in the days after prolonged exercise. These changes could be associated with increased exercise-induced oxidative stress. On the basis of alterations in the concentration of ascorbic acid within the blood, it remains unclear if regular exercise increases the metabolism of vitamin C. However, the similar dietary intakes and responses to supplementation between athletes and nonathletes suggest that regular exercise does not increase the requirement for vitamin C in athletes. Two novel hypotheses are put forward to explain recent findings of attenuated levels of cortisol postexercise following supplementation with high doses of vitamin C.

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Section: Ascorbic Acid and Cortisolmentioning

confidence: 99%

Vitamin C: Effects of Exercise and Requirements with Training

Peake¹

2003

International Journal of Sport Nutrition and Exercise Metabolism

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“…An increased requirement for thiamine (2,3), riboflavin (4) , pyridoxine ( 5), and ascorbic acid (6) has been demonstrated following prolonged exposure to cold. Available data indicate that requirements for a number of nutrients are increased under conditions of low environmental temperature.…”

Section: Results Exp I Seventy Female Rats Ofmentioning

confidence: 99%

Decreased Resistance of Vitamin Bi2-Deficient Rats to Cold Stress.

Ershoff

1953

Experimental Biology and Medicine

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615highest. In our studies with rats, the organ of maximum uptake following intravenous injection of acetate buffered Cr51C13 was also the bone. With CrS1Cl3 in rats and sheep the organs of maximum concentration were the liver and lung, respectively. The high uptake by the lung of the sheep may have resulted from increased phagocytosis of particulate material by the lungs of these animals due to a lung infection which had been prevalent in the flock.Summary. The physiological behavior of trivalent and hexavalent has been observed over a 45-day period in rats as affected by chemical form and route of administration. When intravenously administered as sodium chromite, practically 100% of the dose was picked up by the organs of the reticuloendothelial system. Chromic chloride resulted in a pickup by the liver of about 55% of the dose. When Cr51C13 was added to isotonic acetate and citrate buffers, less than 5% of the dose reached the liver and most of the activity was excreted in the urine. The use of sodium chromate solutions resulted in about 25% of the dose reaching the liver. However, the activity left this organ rapidly in contradistinction to the other forms studied. Oral, intraperitoneal and intratracheal administration of Cr51C13 were also studied. None of the forms of Cr51 used were found to cross the placenta of rats ranging from 15 to 20 days in gestation. In addition, data are presented from 2 sheep intravenously dosed with CrW13. The above physiological observations are correlated with the colloidal behavior, complex formation, protein binding, and red cell binding, and are in general agreement with interpretations of filter paper electrophoretic studies of the dosing solutions.

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“…Increasing the fat constituent of the diet has been shown to have salutary effects upon temperature maintenance in humans (Mitchell, Glickman, Lambert, Keeton, & Fahnestock, 1946), and upon survival time in rats exposed to cold environments (Dugal, 1944;Dugal & Therien, 1947;Giaja & Gelineo, 1934). Hamilton (1963) found that a high fat diet reduced the amount of heat rats worked for when exposed to cold.…”

Section: Effects Of High Fat Diets On Caloric Intake Body Weight and ...mentioning

confidence: 99%

Effects of high fat diets on caloric intake body weight, and heat-escape responses in normal and hyperphagic rats.

Lipton¹

1969

Journal of Comparative and Physiological Psychology

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Ascorbic Acid and Acclimatization to Cold Environment

Cited by 28 publications

References 0 publications

Vitamin C: Effects of Exercise and Requirements with Training

Vitamin C: Effects of Exercise and Requirements with Training

Decreased Resistance of Vitamin Bi2-Deficient Rats to Cold Stress.

Effects of high fat diets on caloric intake body weight, and heat-escape responses in normal and hyperphagic rats.

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