Ascorbic acid analogue 6-Deoxy-6-[18F] fluoro-L-ascorbic acid as a tracer for identifying human colorectal cancer with SVCT2 overexpression

He, Ping; Zhang, Bing; Zou, Yuan; Zhang, Yan; Zha, Zhihao; Long, Ya‐Qiu; Jia, Quanli; Shen, Wanqing; Lin, Xiaoping; Li, Zhoulei; Zhang, Xiangsong

doi:10.1016/j.tranon.2021.101055

Cited by 4 publications

(1 citation statement)

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“…The multidrug resistance extrusion systems on the cell surface which are inducible due to chemotherapeutic treatment as a protection against cytotoxic agents and cellular survival strategy should also not be neglected [ 289 , 290 ]. Besides the ROS induction and capability of disrupting intracellular iron metabolism, the anticancer activity of pharmacological ascorbate includes its modulation of SVCT2 activity by adding Mg 2+ , acting on tumor stem cells, and modulating epigenetics due to a hormetic response [ 25 , 193 , 291 ]. In summary, there is an urgent need for a nuanced understanding of the interplay between ascorbate, hydrogen peroxide transporters, and iron shuttle systems for sufficient ferroptosis induction, and it is necessary to identify tumors sensitive to ascorbate therapy to further substantiate the success of this application ( Figure 2 ).…”

Section: Discussionmentioning

confidence: 99%

Relevant Membrane Transport Proteins as Possible Gatekeepers for Effective Pharmacological Ascorbate Treatment in Cancer

et al. 2023

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Despite the increasing number of newly diagnosed malignancies worldwide, therapeutic options for some tumor diseases are unfortunately still limited. Interestingly, preclinical but also some clinical data suggest that the administration of pharmacological ascorbate seems to respond well, especially in some aggressively growing tumor entities. The membrane transport and channel proteins are highly relevant for the use of pharmacological ascorbate in cancer therapy and are involved in the transfer of active substances such as ascorbate, hydrogen peroxide, and iron that predominantly must enter malignant cells to induce antiproliferative effects and especially ferroptosis. In this review, the relevant conveying proteins from cellular surfaces are presented as an integral part of the efficacy of pharmacological ascorbate, considering the already known genetic and functional features in tumor tissues. Accordingly, candidates for diagnostic markers and therapeutic targets are mentioned.

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