Ascorbic Acid Ameliorates Nicotine Exposure Induced Impaired Spatial Memory Performances in Rats

Sirasanagandla, Srinivasa Rao; Rooben, Rk K.; Rajkumar, S. Vincent; Narayanan, Sareesh Naduvil; Jetti, Raghu

doi:10.7727/wimj.2013.089

Cited by 8 publications

(9 citation statements)

References 33 publications

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“…Attenuation of oxidative stress and alleviation of the antioxidant defenses is another mechanism we hypothesized to contribute to the protective effect of C. sinensis on nicotine-induced neurodevelopmental and behavioral changes in mice newborn. Our hypothesis is supported by findings of multiple studies demonstrating alleviated neurobehavioral performance in experimental animals supplemented with antioxidants [ 30 , 62 ]. Previous studies have attributed memory impairment following prenatal nicotine exposure to excessive production of ROS and its subsequent cell death in various brain regions [ 28 – 30 ].…”

Section: Discussionsupporting

confidence: 83%

“…Our hypothesis is supported by findings of multiple studies demonstrating alleviated neurobehavioral performance in experimental animals supplemented with antioxidants [30, 62]. Previous studies have attributed memory impairment following prenatal nicotine exposure to excessive production of ROS and its subsequent cell death in various brain regions [28–30].…”

Section: Discussionsupporting

confidence: 82%

“…Nicotine has been reported to induce oxidative stress both in vivo [ 25 , 26 ] and in vitro [ 27 ]. Also, nicotine-induced cell death in various brain regions and memory impairment have been attributed to excessive ROS production [ 28 – 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Camellia sinensis Prevents Perinatal Nicotine-Induced Neurobehavioral Alterations, Tissue Injury, and Oxidative Stress in Male and Female Mice Newborns

Ajarem

Al-Basher

Allam

et al. 2017

Oxidative Medicine and Cellular Longevity

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Nicotine exposure during pregnancy induces oxidative stress and leads to behavioral alterations in early childhood and young adulthood. The current study aimed to investigate the possible protective effects of green tea (Camellia sinensis) against perinatal nicotine-induced behavioral alterations and oxidative stress in mice newborns. Pregnant mice received 50 mg/kg C. sinensis on gestational day 1 (PD1) to postnatal day 15 (D15) and were subcutaneously injected with 0.25 mg/kg nicotine from PD12 to D15. Nicotine-exposed newborns showed significant delay in eye opening and hair appearance and declined body weight at birth and at D21. Nicotine induced neuromotor alterations in both male and female newborns evidenced by the suppressed righting, rotating, and cliff avoidance reflexes. Nicotine-exposed newborns exhibited declined memory, learning, and equilibrium capabilities, as well as marked anxiety behavior. C. sinensis significantly improved the physical development, neuromotor maturation, and behavioral performance in nicotine-exposed male and female newborns. In addition, C. sinensis prevented nicotine-induced tissue injury and lipid peroxidation and enhanced antioxidant defenses in the cerebellum and medulla oblongata of male and female newborns. In conclusion, this study shows that C. sinensis confers protective effects against perinatal nicotine-induced neurobehavioral alterations, tissue injury, and oxidative stress in mice newborns.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 82%

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Camellia sinensis Prevents Perinatal Nicotine-Induced Neurobehavioral Alterations, Tissue Injury, and Oxidative Stress in Male and Female Mice Newborns

Ajarem

Al-Basher

Allam

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Mothers’ smoking was not affecting children’s memory because most mothers were not smokers as this practice is not socially acceptable among women in Jordanian culture. Available literature found that smoking status of parents was negatively associated with memory and academic performance of children [ 14 , 15 , 37 , 38 ]. For example, a large study found that children with different memory disabilities were more exposed to second hand smoking than their peers [ 39 ] highlighting the negative effect of nicotine exposure on working memory [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Memory and potential correlates among children in Jordan

et al. 2018

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BackgroundCognitive functioning hugely affects the performance of tasks of different complexity. Memory, one of the most important cognitive skills, allows children to practice and acquire necessary skills and knowledge and interact with the surrounding environment. Therefore, it is crucial to study the factors that influence the memory of children. The main purpose of his study was to investigate different variables related to memory in school aged children (5–9 years, N = 434).MethodsParents of the participants provided information about child’s daily behavior, child’s school academic achievement, work and family income data and demographics. Memory skills in children were assessed by using the Leiter International Performance Scale -Revised.ResultsThe score of memory increased 2.53 points with upsurge in maternal occupation level, 3.08 points when the child ate breakfast and 4.51 points when the child daily slept nine hours and more. By contrast, increased family income and smoking by father resulted in decreased scores in memory.ConclusionScreening for and understanding of memory and relevant factors are vital for broad understanding of children’s capabilities and weaknesses as well as for developing appropriate interventions.

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“…One "candidate" beneficial dietary exposure is vitamin C. Vitamin C is an anti-oxidant that helps antagonise the nicotine induced damage [18,19], or alterations in lung metabolism [20] and there is some indication that it prevents offspring DNA methylation changes associated with maternal smoking in pregnancy [21]. Previous work also suggests that vitamin C can reduce the nicotine exposure induced impaired neurological functioning in rats [22], and reduce the risk of developing sudden infant death syndrome [23]. In other animal experiments vitamin C seems to antagonise the negative effects of prenatal exposure to nicotine on the development of the lungs [24,25].…”

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confidence: 99%

Vitamin C against the harmful effects of prenatal passive smoking: when all other options fail?

Merkus

Turner

2020

Eur Respir J

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Ascorbic Acid Ameliorates Nicotine Exposure Induced Impaired Spatial Memory Performances in Rats

Abstract: ABSTRACT

Cited by 8 publications

References 33 publications

Camellia sinensis Prevents Perinatal Nicotine-Induced Neurobehavioral Alterations, Tissue Injury, and Oxidative Stress in Male and Female Mice Newborns

Camellia sinensis Prevents Perinatal Nicotine-Induced Neurobehavioral Alterations, Tissue Injury, and Oxidative Stress in Male and Female Mice Newborns

Memory and potential correlates among children in Jordan

Vitamin C against the harmful effects of prenatal passive smoking: when all other options fail?

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