“…However, in the case of topical application, fresh Vitamin C must be applied to the skin by iontophoresis to achieve clinical improvement, because of its poor penetration of the skin and its instability in formulations [18,19]. To cover these defects of Vitamin C, many kinds of derivatives, such as magnesium Lascorbyl-2-phosphate (VC-PMg) [20], ascorbic acid 2-O-alpha-glucoside [21], ascorbyl palmitate [22] and 6-acylated ascorbic acid 2-O-alpha-glucoside [23] have been synthesized.…”