Ascorbic Acid 2-O-.ALPHA.-Glucoside, a Stable Form of Ascorbic Acid, Rescues Human Keratinocyte Cell Line, SCC, from Cytotoxicity of Ultraviolet Light B.

Role of antioxidants in the skin: Anti-aging effects

“…Although ascorbic acid is widely applied to the skin to achieve these clinical improvements, its poor skin penetration and its instability in formulations reduce its clinical efficacy [57]. To overcome these disadvantages, several ascorbic acid derivatives, such as magnesium L-ascorbyl-2-phosphate [58], ascorbic acid 2-O-a-glucoside [59], 6-acylated ascorbic acid 2-O-a-glucoside [60], and tetra-isopalmitoyl ascorbic acid [61], have been synthesized and evaluated for their potential as pro-ascorbic acid derivatives.…”

A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties

“…However, in the case of topical application, fresh Vitamin C must be applied to the skin by iontophoresis to achieve clinical improvement, because of its poor penetration of the skin and its instability in formulations [18,19]. To cover these defects of Vitamin C, many kinds of derivatives, such as magnesium Lascorbyl-2-phosphate (VC-PMg) [20], ascorbic acid 2-O-alpha-glucoside [21], ascorbyl palmitate [22] and 6-acylated ascorbic acid 2-O-alpha-glucoside [23] have been synthesized.…”

Antioxidants and Skin Aging

“…To overcome those disadvantages, several ascorbic acid derivatives, such as magnesium L-ascorbyl-2-phosphate (Kameyama et al 1996), ascorbic acid 2-O-a-glucoside (Miyai et al 1996), 6-acylated ascorbic (Zhou et al 2003), and tetra-isopalmitoyl ascorbic acid (Ochiai et al 2006), have been synthesized and evaluated for their potential as pro-ascorbic acid derivatives.…”