Ascorbate, estradiol, and the immune response in guinea pigs

Feigen, George A.; Smith, Brigitte H. E.; Fraser, R C; Dix, Carolin; Flynn, Cheryl J.; Peterson, Nancy

doi:10.1016/0192-0561(80)90188-5

Cited by 1 publication

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“…There are conflicting data on the effect of vitamin C on the production of antibodies by B lymphocytes. High-dose VC supplementation increased the immunoglobulin level in healthy volunteers, guinea pigs, and chickens [30][31][32][33][34], whereas in other animal models (dog, mouse) VC supplementation had no effect on antigen-induced immunoglobulin levels after immunization [35,36]. Our data reveal that VC effect is possibly subject to a combination of sex and genotype (Table 1).…”

Section: Discussionmentioning

confidence: 72%

The Effect of Vitamin C on Blood Lymphocytes of American Mink (Neovison Vison): Variation with Sex and Genotype

Kizhina

Ilyukha²,

Rossinskaya

2023

Braz. arch. biol. technol.

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Vitamin C (VC) is involved in many biological processes including immune response. This experiment was conducted to investigate the effects of supplemental VC on the development of mink lymphocytes in wild type (Standard genotype mink) and animal model of Chediak-Higashy (CH) syndrome (Sapphire genotype mink). Chediak-Higashy syndrome is genetically determined disease of human and animals affecting morphology and functions different cells including leukocytes. Using morphometry and cytochemistry methods, we reveal that VC supplementation (100 mg/animal/day) induces lymphocyte activation in wild type mink and CH-like mink. However, the effect of VC supplementation is sex-related and depends on the genotype of mink. In general, we obtained data that VC supplementation neutralizes genotype-related size differences among lymphocytes.

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