Ascorbate-2-sulfate sulfohydrolase in fish and mammal. Comparative characterization and possible involvement in ascorbate metabolism

Dąbrowski, Konrad; Lackner, Reinhard; Doblander, C.

doi:10.1016/0305-0491(93)90203-h

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Ascorbate-2-sulphate is also able to relieve the signs of scurvy (at least in ®sh), and the enzyme ascorbate-2-sulphohydrolase has been puri-®ed and characterised. 14 onide and 2-O-a-glucoside have been found in humans and guinea pigs respectively, 15±17 and several C 5 -linked glycosides of 6-deoxyascorbate have been identi®ed in mushroom. 18 The possible existence and function of such derivatives in plant tissues has received very little attention however.…”

Section: Chemical Properties Structurementioning

confidence: 99%

Plant L‐ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing

Davey

Montagu

Inzé

et al. 2000

J. Sci. Food Agric.

465

612

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Humans are unable to synthesise L-ascorbic acid (L-AA, ascorbate, vitamin C), and are thus entirely dependent upon dietary sources to meet needs. In both plant and animal metabolism, the biological functions of L-ascorbic acid are centred around the antioxidant properties of this molecule. Considerable evidence has been accruing in the last two decades of the importance of L-AA in protecting not only the plant from oxidative stress, but also mammals from various chronic diseases that have their origins in oxidative stress. Evidence suggests that the plasma levels of L-AA in large sections of the population are sub-optimal for the health protective effects of this vitamin.Until quite recently, little focus has been given to improving the L-AA content of plant foods, either in terms of the amounts present in commercial crop varieties, or in minimising losses prior to ingestion. Further, while L-AA biosynthesis in animals was elucidated in the 1960s, 1 it is only very recently that a distinct biosynthetic route for plants has been proposed. 2 The characterisation of this new pathway will undoubtedly provide the necessary focus and impetus to enable fundamental questions on plant L-AA metabolism to be resolved.This review focuses on the role of L-AA in metabolism and the latest studies regarding its biosynthesis, tissue compartmentalisation, turnover and catabolism. These inter-relationships are considered in relation to the potential to improve the L-AA content of crops. Methodology for the reliable analysis of L-AA in plant foods is brie¯y reviewed. The concentrations found in common food sources and the effects of processing, or storage prior to consumption are discussed. Finally the factors that determine the bioavailability of L-AA and how it may be improved are considered, as well as the most important future research needs.

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Section: Chemical Properties Structurementioning

confidence: 99%

Plant L‐ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing

Davey

Montagu

Inzé

et al. 2000

J. Sci. Food Agric.

465

612

View full text Add to dashboard Cite

show abstract

“…Ascorbate‐2‐sulphate was initially discovered in brine shrimp cysts, and later found to be present in soft tissues and as a urinary metabolite of L‐AA in animals. Ascorbate‐2‐sulphate is also able to relieve the signs of scurvy (at least in fish), and the enzyme ascorbate‐2‐sulphohydrolase has been purified and characterised 14. Ascorbic acid‐2‐ O ‐β‐glucuronide and 2‐ O ‐α‐glucoside have been found in humans and guinea pigs respectively,15–17 and several C 5 ‐linked glycosides of 6‐deoxyascorbate have been identified in mushroom 18.…”

Section: Chemical Propertiesmentioning

confidence: 99%

PlantL-ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing

Davey

Montagu

Inzé

et al. 2000

J. Sci. Food Agric.

1,071

173

View full text Add to dashboard Cite

Humans are unable to synthesise L‐ascorbic acid (L‐AA, ascorbate, vitamin C), and are thus entirely dependent upon dietary sources to meet needs. In both plant and animal metabolism, the biological functions of L‐ascorbic acid are centred around the antioxidant properties of this molecule. Considerable evidence has been accruing in the last two decades of the importance of L‐AA in protecting not only the plant from oxidative stress, but also mammals from various chronic diseases that have their origins in oxidative stress. Evidence suggests that the plasma levels of L‐AA in large sections of the population are sub‐optimal for the health protective effects of this vitamin. Until quite recently, little focus has been given to improving the L‐AA content of plant foods, either in terms of the amounts present in commercial crop varieties, or in minimising losses prior to ingestion. Further, while L‐AA biosynthesis in animals was elucidated in the 1960s,1 it is only very recently that a distinct biosynthetic route for plants has been proposed.2 The characterisation of this new pathway will undoubtedly provide the necessary focus and impetus to enable fundamental questions on plant L‐AA metabolism to be resolved. This review focuses on the role of L‐AA in metabolism and the latest studies regarding its biosynthesis, tissue compartmentalisation, turnover and catabolism. These inter‐relationships are considered in relation to the potential to improve the L‐AA content of crops. Methodology for the reliable analysis of L‐AA in plant foods is briefly reviewed. The concentrations found in common food sources and the effects of processing, or storage prior to consumption are discussed. Finally the factors that determine the bioavailability of L‐AA and how it may be improved are considered, as well as the most important future research needs. © 2000 Society of Chemical Industry

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Characterization of arylsulfatase activity in brine shrimp, Artemia salina

Matusiewicz

Krzystek−Korpacka

Dąbrowski

2005

Journal of Experimental Marine Biology and Ecology

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Ascorbate-2-sulfate sulfohydrolase in fish and mammal. Comparative characterization and possible involvement in ascorbate metabolism

Cited by 4 publications

References 17 publications

Plant L‐ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing

Plant L‐ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing

PlantL-ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing

Characterization of arylsulfatase activity in brine shrimp, Artemia salina

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