Ascitic Calprotectin is a Novel and Accurate Marker for Spontaneous Bacterial Peritonitis

Abstract

Ascitic calprotectin appears to be a reliable method for diagnosing SBP in patients with liver cirrhosis. It may present an alternative to other conventional diagnostic methods.

Accuracy of calprotectin using the Quantum Blue Reader for the diagnosis of spontaneous bacterial peritonitis in liver cirrhosis

“…Using an optimal threshold of 1.57 μg/mL, POCT had a fairly good capacity to diagnose or exclude SBP (sensitivity 87.8%, specificity 97.9%, PPV 97.3%, and NPV 90.2%). Our lower PPV (65.9%), as compared with the 97.3% observed previously, might be explained by the lower threshold used in the present study (1.51 μg/mL), which inevitably increases the number of true positive, but also of false positive cases, thus contributing to the decrease in PPV. For clinical decision‐making in life‐threatening disease (such as SBP), the NPV (97.3% in the present study) must be preferred.…”

A novel turbidimetric immunoassay for fecal calprotectin optimized for routine chemistry analyzers

“…Endoscopic evaluation with ileocolonoscopy is the gold standard for the diagnosis of IBD but the endoscopies are invasive, costly, and time‐consuming. Patients with inflammatory disorders often have elevated levels of calprotectin in blood or feces . The main clinical use of calprotectin is, however, as a fecal marker to exclude IBD .…”

“…Patients with inflammatory disorders often have elevated levels of calprotectin in blood or feces. [16][17][18][19] The main clinical use of calprotectin is, however, as a fecal marker to exclude IBD. 20 Traditionally, F-calprotectin has been analyzed by ELISA using microtiter plates.…”

Ascitic calprotectin as a useful marker in the diagnosis of spontaneous bacterial peritonitis in adults

“…Studies were conducted on alternatives of the ascitic PMN count as high sensitivity C-reactive protein (hsCRP) [6], serum procalcitonin [7], urinary lipocalin [8], ascitic lactoferrin [9], homocysteine [10] and fecal or ascitic calprotectin [11,12].…”