Ascites and highly elevated CA-125 levels in a case of peritoneal tuberculosis

Younossian, Alain Bigin; Rochat, Thierry; Favre, L.; Janssens, Jean–Paul

doi:10.1080/00365540500333764

Cited by 16 publications

(7 citation statements)

References 6 publications

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“…In this patient from India, who had appendiceal tuberculosis several years age, a chronic inflammation of the right adnexe developed, which had clinical and radiological features similar to ovarian cancer. Adnexitis is one of the most common intraabdominal manifestations of tuberculosis [2,13]. Our series includes no patient with HIV infection, no homeless individual and no elderly individual with reactivation.…”

Section: Discussionmentioning

confidence: 99%

“…As the disease per se is rare in industrialized countries, very few cases of abdominal tuberculosis are described and therefore, timely diagnosis is a challenge [5][6][7]. Intraabdominal masses or peritoneal nodules together with ascites are common findings in abdominal tuberculosis but may also be suggestive for several other pathologies such as gastrointestinal or gynaecological malignancies, lymphomas, or inflammatory bowel disease [6,[8][9][10][11][12][13]. In fact several publications from industrialized countries emphasize that initial diagnosis included those mentioned above before abdominal tuberculosis was diagnosed upon laparoscopy.…”

Section: Introductionmentioning

confidence: 99%

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Abdominal tuberculosis: experience with three cases from an Austrian centre

et al. 2009

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Zusammenfassung. Grundlagen: Die Tuberkulose ist nach wie vor eine häufige Infektion in der dritten Welt. In industrialisierten Ländern ist diese Erkrankung relativ selten. Die peritoneale Tuberkulose ist schwierig zu diagnostizieren und kann mit intraabdominellen Malignomen verwechselt werden.Methodik: Wir beschreiben zwei Patienten mit peritonealer und einen Patienten mit Dickdarmtuberkulose.Ergebnisse: Drei Frauen wurden mit unspezifischen abdominellen Symptomen hospitalisiert. Bei zwei Patientinnen wurde radiologisch der Verdacht auf ein intraabdominelles Malignom ausgesprochen -in einem Fall ein Magen-im anderen ein Ovarialkarzinom. In beiden Fällen erfolgte die korrekte Diagnosestellung aus laparoskopisch gewonnenem Gewebe. Die dritte Patientin entwickelte sechs Jahre nach erfolgreicher Nierentransplantation akute Bauchschmerzen und blutigen Durchfall. Die Diagnose einer Kolontuberkulose wurde endoskopisch gestellt. Alle Patientinnen wurden erfolgreich tuberkulostatisch behandelt. In einem Fall wurde ein multiresistenter Stamm von Mycobacterium tuberculosis isoliert.Schlussfolgerungen: Die intraabdominelle Tuberkulose kann sich klinisch ähnlich einer gastrointestinalen oder gynäkologischen Krebserkrankung präsentieren. Mittels Laparoskopie and Endoskopie mit Gewebsbiopsie kann die korrekte Diagnose rasch gestellt und eine entsprechende Therapie eingeleitet werden.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Abdominal tuberculosis: experience with three cases from an Austrian centre

et al. 2009

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“…Thus, serum CA-125 is considered a nonspecific marker of peritoneal involvement. It has been reported that serum CA-125 levels are increased in patients with tuberculous peritonitis (11,12). Of note, CA-125 is expressed in the coelomic epithelium, such as the pleura, peritoneum, and pericardium (13).…”

Section: Discussionmentioning

confidence: 99%

A Case of Tuberculous Peritonitis in a Hemodialysis Patient with High Serum Soluble Interleukin-2 Receptor and CA-125 Levels

et al. 2010

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A hemodialysis patient with tuberculous peritonitis with hypercalcemia and high serum soluble interleukin-2 receptor (sIL-2R) and CA-125 levels is reported. An 82-year-old woman who had been on hemodialysis therapy for 6 years was admitted to our hospital for evaluation and treatment of hypercalcemia. Laboratory examination and radiologic studies revealed markedly increased serum sIL-2R and CA-125 levels and exudative ascites, with high levels of adenosine deaminase (ADA) and CA-125, which was suggestive of malignancy or tuberculosis. She was finally diagnosed as having tuberculous peritonitis based on positivity for Mycobacterium tuberculosis in ascitic fluid. The ascites subsided with normalization of hypercalcemia and a marked decrease in serum sIL-2R and CA-125 levels in response to anti-tuberculosis treatment. This case indicates that serum sIL-2R and CA-125 levels can rise to levels suggestive of malignancy in tuberculous peritonitis, and that they can be used to monitor the response to anti-tuberculosis treatment.

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“…19 In the present study 46 patients out of a total of 50 had elevated serum CA-125 levels at 0 months thus affirming to the observations in other studies. [20][21][22][23][24] Several studies have also observed a close correlation between the normalization of CA-125 levels with the response to anti-tuberculous therapy. 25,26 Author on present study also found a steady decline in the elevated CA-125 levels coupled with clinical improvement after initiation of antitubercular therapy.…”

Section: Discussionmentioning

confidence: 99%

The diagnostics significance of serum cancer antigen-125 in abdominal tuberculosis

et al. 2018

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Background: Various serum markers have been shown to be helpful in diagnosing tubercular infection, but none has been proven to be specific. The present study was undertaken to ascertain the role of serum cancer antigen (CA) -125 in diagnosing and monitoring therapeutic response in abdominal tuberculosis.Methods: Fifty diagnosed cases of abdominal tuberculosis and equal number of controls were included in the study. All the patients underwent clinical, radiological and hematological examination. Twenty-two patients had acute presentation and underwent laparotomy and twenty-eight patients had a chronic presentation and were managed conservatively. Biopsy was taken in all patients undergoing laparotomy. Serial measurement of serum levels of CA-125 were done at 0, 3 and 6 months in all the patients.Results: The CA-125 levels were significantly higher in tuberculosis patients than in control group (PPV 95.74% at 0 month). It was also observed that the levels correlated significantly with the disease activity (sensitivity 90 percent, specificity 96 percent) and return to normal level with the treatment given. It was shown that sensitivity reduced to 12 percent and 6 percent at 3 months and 6 months respectively after completion of treatment. The specificity however remained unchanged.Conclusions: The measurement of CA-125 may be a valuable parameter in diagnosing and determination of disease activity in abdominal tuberculosis.

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Ascites and highly elevated CA-125 levels in a case of peritoneal tuberculosis

Cited by 16 publications

References 6 publications

Abdominal tuberculosis: experience with three cases from an Austrian centre

Abdominal tuberculosis: experience with three cases from an Austrian centre

A Case of Tuberculous Peritonitis in a Hemodialysis Patient with High Serum Soluble Interleukin-2 Receptor and CA-125 Levels

The diagnostics significance of serum cancer antigen-125 in abdominal tuberculosis

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