Ascherman Syndrome: From Etiology to Prevention

Abstract

Asherman's syndrome is a mysterious, multifaceted disease characterized by the formation ofintrauterine synechiae, up to complete obliteration of the uterine cavity. This is a very controversial topicbecause of its pronounced effect on both the reproductive prognosis (infertility, habitual miscarriage) andgynecological symptoms (menstrual dysfunction of the type of oligo-amenorrhea). Although the syndromehas been extensively studied, there is no clear evidence of both its prevention and effective treatment. Themain reason for the formation of intrauterine adhesions is recognized by most authors as endometrial injury.Understanding the pathogenesis of their formation is necessary to prevent the development of endometrialfibrosis and sclerosis. The review article presents in detail the causes of the disease, risk factors, clinicalmanifestations, and methods for diagnosing this syndrome. Therapeutic measures are presented in step-bystep low-traumatic ways to eliminate intrauterine adhesions with subsequent restoration of menstrual andreproductive functions. Particular attention is paid to anti-relapse prevention through the prescription ofintrauterine anti-adhesion gels.