Ascending to descending aortic pulse pressure amplification in children

Murakami, Tomoaki; Shiraishi, Masaya; Nawa, Tomohiro; Takeda, Atsuhito

doi:10.1097/hjh.0000000000001313

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…The negative correlation among PPA with TVR, AP, and reflection coefficient observed in the current study, reinforces the concept of the inverse association between PPA reduction and arterial stiffness. Different from Mukarami et al, in the present study, PPA did not correlated with age. It was also observed that AIx@75 was inversely related to the PPA in the DM1 group.…”

Section: Discussioncontrasting

confidence: 99%

“…The PPp/PPc ratio, also known as pulse pressure amplification (PPA), is an important physiological function to protect the heart against afterload and microcirculation from pulsatile pressure stress. Mukarami et al demonstrated that PPA is present in children. Contrary to what happens with adult population, PPA increases in with age during childhood.…”

Section: Introductionmentioning

confidence: 99%

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Changes in aortic pulse wave components, pulse pressure amplification, and hemodynamic parameters of children and adolescents with type 1 diabetes

et al. 2018

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FCM-MG), Pós-Graduação em Ciências da Saúde Background/Objective: Type 1 diabetes mellitus (DM1) presents important risk factors for cardiovascular events.Objective: To compare the components of the aortic pulse wave (APW) and the hemodynamic parameters among children and adolescents with DM1 and healthy individuals.Methods: This is a cross-sectional study, with 36 children and adolescents diagnosed with DM1 (11.9 AE 3.2 years) matched by sex and age with the control group (n = 36, 12.4 AE 2.9 years).The components of the APW and the hemodynamic parameters were evaluated non-invasively, using Mobil-O-Graph. Results: On the week of the evaluation, DM1 patients presented glycated hemoglobin (hemoglobin A1C [HbA1c]) of 9.48 AE 2.22% and fasting glycemia of 222.58 AE 93.22 mg/dL. Augmentation index (AIx@75), reflection coefficient, and augmentation pressure (AP) were significantly higher in the DM1 group (29.0 AE 9.7%, 63.0 AE 7.9, and 7.8 AE 2.7 mm Hg, respectively) compared with the control group (20.6 AE 7.9%, 53.4 AE 9.1 and 4.9 AE 2.1 mm Hg, respectively). The systolic volume (52.6 AE 11.9 and 60 AE 12.4 mL) and the cardiac output (4.3 AE 0.5 and 4.6 AE 0.5 L/min) decreased in the DM1 group in relation to the control group. The pulse pressure amplification (PPA) was significantly lower in the DM1 group (1.4 AE 0.15) compared with the control group (1.6 AE 0.17). PPA correlated negatively with total vascular resistance (TVR), AP and reflection coefficient, and positively with cardiac index in both groups. In the DMI group, the AIx@75 correlated negatively with age, height, systolic volume, and PPA, and correlated positively with the TVR and reflection coefficient. Conclusions: These results confirm the presence of arterial stiffness in this population and extend the knowledge, showing, for the first time, the reduction of PPA in the DM1 group.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in aortic pulse wave components, pulse pressure amplification, and hemodynamic parameters of children and adolescents with type 1 diabetes

et al. 2018

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“…These authors observed that contrary to what happens in adulthood, PPA increases during childhood. Mukarami et al evaluated PPA in two ways: by the difference between PP in the descending aorta and PP in the ascending aorta, and by the PP descending / PP ascending ratio [ 11 ]. These same authors also showed a reduction in PPA in patients after aortic arch repair when compared to the control group [ 12 ] and after surgery for complete transposition of great arteries [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Mukarami et al were the first to study PPA in children and adolescents. These authors observed that PPA is present in children, but contrary to what happens in adulthood, it increases during childhood [ 11 ]. These same authors also showed a reduction in PPA in patients after aortic arch repair when compared to the control group [ 12 ] and after surgery for complete transposition of great arteries [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with arterial stiffness assessed by pulse pressure amplification in healthy children and adolescents: a cross-sectional study

et al. 2023

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Background Increasing evidence suggests that reducing pulse pressure amplification (PPA) plays an important role in pathogenesis and progression of cardiovascular disease. This is a cross-sectional, observational, and analytical study in which we evaluated the associated factors with a greater chance of reducing PPA in 136 healthy children and adolescents aged 8 to 19 years old stratified by gender and age group. Methods Arterial stiffness and vascular and hemodynamic parameters were non-invasively measured using Mobil-O-Graph® (IEM, Stolberg, Germany), a cuff-based oscillometric device. PPA was expressed as the peripheral-to-central pulse pressure ratio (PPp / PPc). Participants with PPA < 1.49 were considered as part of the arterial stiffness group. Results In a univariate model, the increase in total vascular resistance, the reflection coefficient and the augmentation pressure were more likely to have arterial stiffness in all groups. The factors most likely to have arterial stiffness (as assessed by the reduction of the PPA) in the multivariate model were increasing age, the reflection coefficient and cardiac index in the total sample, male group and child and adolescent groups. In addition to age in the female group, cardiac output, stroke volume, and AIx@75 were the factors most likely to present arterial stiffness. Conclusions The results show for the first time in children and adolescents that the factors most likely to reduce PPA are related to the reflection wave, which determines aortic pressures and, therefore, left ventricular afterload.

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“…1 Identifying the components of early life blood pressure(BP) are of critical importance as evidence builds on the role of BP in predicting future atherosclerotic cardiovascular disease (ASCVD). Classic literature has demonstrated the ability for historical BP to predict presence of atherosclerotic plaque in younger persons victim to unfortunate mortality like accident and war.…”

mentioning

confidence: 99%

Pulse wave reflection in children

Zachariah¹

2017

Journal of Hypertension

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Ascending to descending aortic pulse pressure amplification in children

Abstract: The PP amplification is observed even in children. The degree of the PP amplification increases with age during childhood contrary to the relationship in adults.

Cited by 8 publications

References 22 publications

Changes in aortic pulse wave components, pulse pressure amplification, and hemodynamic parameters of children and adolescents with type 1 diabetes

Changes in aortic pulse wave components, pulse pressure amplification, and hemodynamic parameters of children and adolescents with type 1 diabetes

Factors associated with arterial stiffness assessed by pulse pressure amplification in healthy children and adolescents: a cross-sectional study

Pulse wave reflection in children

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