Ascending Nociceptive Control Contributes to the Antinociceptive Effect of Acupuncture in a Rat Model of Acute Pain

Tobaldini, Gláucia; Aisengart, Betina; Lima, Marcelo M.S.; Tambeli, Cláudia Herrera; Fischer, Luana

doi:10.1016/j.jpain.2013.12.008

Cited by 25 publications

(13 citation statements)

References 56 publications

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“…Acupuncture-induced analgesia depends on the activation of endogenous pain modulation pathways [1]. Tobaldini G asked whether ascending nociceptive control (ANC), a form of pain-induced analgesia, contributes to the antinociceptive effect of acupuncture.…”

Section: Spinal Cord Level Integrationmentioning

confidence: 99%

The Neural Mechanism of Acupuncture Analgesia

Xu¹,

Liu²

2017

Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)

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Section: Spinal Cord Level Integrationmentioning

confidence: 99%

The Neural Mechanism of Acupuncture Analgesia

Xu¹,

Liu²

2017

Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)

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“…Acupuncture-induced effects interact with and coordinate different levels of the CNS. The effect of acupuncture-induced analgesia is considered to be a complicated process (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30).…”

Section: Acupuncture-induced Analgesia May Act On Different Levels Ofmentioning

confidence: 99%

“…Furthermore, opioid peptides may be involved in acupuncture analgesia in the spinal cord to varying degrees (15). Pharmacological inhibition of ascending nociceptive control at the spinal cord, nucleus accumbens or supraspinal may prevent acupuncture-induced analgesia (16).…”

Section: Acupuncture-induced Analgesia May Act On Different Levels Ofmentioning

confidence: 99%

Acupuncture: Emerging evidence for its use as an analgesic (Review)

Gao

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Acupuncture is an ancient Chinese technique, developed over >3,000 years, in which ʻacupointsʼ are stimulated with the aim of treating various diseases. A number of previous studies have indicated that acupuncture may play a role in inducing analgesia. Acupuncture-induced analgesia has been hypothesized to act on various parts of the central nervous system, including the spinal cord, brain stem, cerebral ganglia and cerebral cortex. The mechanisms underlying the effects of acupuncture have been purported to include neurohumors and neurotransmitters, such as opioids and γ-aminobutyric acid, signaling pathways and the immune response, which are all involved in the induction of analgesia.

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Section: Key Indexing Termsmentioning

confidence: 99%

“…44 Increasing electrophysiological and neuroreceptor activation evidence implicates thalamic participation in an endogenous analgesic system, which is considered responsible (at least in part) for acupuncture-induced analgesia. 37,[45][46][47] Because acupuncture and spinal manipulative interventions both mechanically stimulate receptors in superficial and deep peripheral tissues, they may share a common mechanism of action via the thalamus.Experimental efforts to better understand the neural effects of spinal manipulation at different levels of central ascending and descending nociceptive processing are needed to help elucidate the mechanisms responsible for its near immediate hypoalgesic effects. Furthermore, identifying which (if any) of the clinician-controlled mechanical parameters of a spinal manipulation can affect convergent ascending central processing will provide critical insight into the central mechanisms and clinical variables responsible for the positive clinical outcomes of spinal manipulation.…”

mentioning

confidence: 99%

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive Specific Lateral Thalamic Neurons

ReedWilliam

SozioRandall

PickarJoel

et al. 2014

The Journal of Alternative and Complementary Medicine

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Objective-The objective of this preliminary study was to determine if high-velocity, lowamplitude spinal manipulation (HVLA-SM) thrust duration alters mechanical trunk activation thresholds of nociceptive-specific (NS) lateral thalamic neurons.Methods-Extracellular recordings were obtained from 18 NS neurons located in 2 lateral thalamic nuclei (ventrolateral [n = 12] and posterior [n = 6]) in normal anesthetized Wistar rats. Response thresholds to electronic von Frey anesthesiometer (rigid tip) mechanical trunk stimuli applied in 3 lumbar directions (dorsal-ventral, 45° caudal, and 45° cranial) were determined before and immediately after the delivery of 3 HVLA-SM thrust durations (time control 0, 100, and 400 milliseconds). Mean changes in mechanical trunk activation thresholds were compared using a mixed model analysis of variance.Results-High-velocity, low-amplitude spinal manipulation duration did not significantly alter NS lateral thalamic neurons' mechanical trunk responses to any of the 3 directions tested with the anesthesiometer.Copyright © 2014 by National University of Health Sciences.Submit requests for reprints to: William R Reed, DC, PhD, 741 Brady St, Davenport, IA 52803. (william.reed@palmer.edu). Potential Conflicts of Interest No conflicts of interest were reported for this study Contributorship Information Concept development (provided idea for the research): W.R.R. Design (planned the methods to generate the results): W.R.R., J.G.P., R.S.S. Supervision (provided oversight, responsible for organization and implementation, writing of the manuscript): W.R.R. Data collection/processing (responsible for experiments, patient management, organization, or reporting data): W.R.R., R.S.S. Analysis/interpretation (responsible for statistical analysis, evaluation, and presentation of the results): W.R.R., J.G.P., S.M.O., R.S.S. Literature search (performed the literature search): W.R.R., S.M.O., R.S.S. Writing (responsible for writing a substantive part of the manuscript): W.R.R., S.M.O. Critical review (revised manuscript for intellectual content, this does not relate to spelling and grammar checking): W.R.R., J.G.P., S.M.O., R.S.S.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptConclusions-This study is the first to examine the effect of HVLA-SM thrust duration on NS lateral thalamic mechanical response thresholds. High-velocity, low-amplitude spinal manipulation thrust duration did not affect mechanical trunk thresholds. Key Indexing TermsManipulation; Spinal; Thalamus; Nociceptive Neuron; Lumbar Vertebrae; ChiropracticSpinal manipulation has been shown to be effective in treating neck and low back pain. [1][2][3] Not only are the neurophysiological mechanisms by which this occurs unknown, but a lack of knowledge also exists regarding the effects of clinician-controlled mechanical application parameters o...

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Ascending Nociceptive Control Contributes to the Antinociceptive Effect of Acupuncture in a Rat Model of Acute Pain

Cited by 25 publications

References 56 publications

The Neural Mechanism of Acupuncture Analgesia

The Neural Mechanism of Acupuncture Analgesia

Acupuncture: Emerging evidence for its use as an analgesic (Review)

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive Specific Lateral Thalamic Neurons

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