Ascaris lumbricoides-induced suppression of total and specific IgE responses in atopic subjects is interleukin 10-independent and associated with an increase of CD25+ cells

Matera, Giovanni; Giancotti, A; Scalise, Sonia; Pulicari, Maria Concetta; Maselli, Roberta; Piizzi, Chiara; Pelaia, Girolamo; Tancrè, Valentina; Muto, Valentina; Doldo, Patrizia; Cosco, V.; Cosimo, Paola; Capicotto, Renata; Quirino, Angela; Scalzo, Rosaria; Liberto, Maria Carla; Parlato, Giuseppe; Focà, Alfredo

doi:10.1016/j.diagmicrobio.2008.06.015

Cited by 20 publications

(25 citation statements)

References 15 publications

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“…These results are in agreement with other investigations that ruling out the relationship between IgE production and IL-10 levels in A. lumbricoides infection. 17,18 B. tropicalis is the most common aeroallergen in the city where the study was conducted, and the standardised extract of this mite presented a greater positivity to the immediate cutaneous hypersensitivity test and specific IgE. 29 The correlation between total IgE, anti-Ascaris IgE and anti-B.…”

Section: Discussionmentioning

confidence: 99%

“…16 However, very few studies have examined the role of this cytokine during geohelminth infections and its relationship with allergies and IgE levels. 17,18 Therefore, the aim of this experimental study was to evaluate the IL-10 production capacity of peripheral blood mononuclear cells from allergic parasitised and non-parasitised children living in an urban area of Northeast Brazil and to evaluate the relationship between parasitic infection, total and specific anti-Ascaris and anti-Blomia IgE levels.…”

Section: Introductionmentioning

confidence: 99%

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Ascaris lumbricoides infection in urban schoolchildren: Specific IgE and IL-10 production

Souza

Medeiros

Sales

et al. 2014

Allergologia et Immunopathologia

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ascaris lumbricoides infection in urban schoolchildren: Specific IgE and IL-10 production

Souza

Medeiros

Sales

et al. 2014

Allergologia et Immunopathologia

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“…However, the importance of IL-10 in helminth-induced suppression of atopic diseases is not fully established; that is, mesenteric lymph node cells from Heligmosomoides -infected IL-10-deficient mice could confer protection against allergic airway inflammation [36]. Likewise, in humans, anti-allergic effect of Ascaris lumbricoides is associated with Treg, but not with IL-10 [57]. In the case of mice, IL-35, a recently identified effecter molecule of Treg cells [58], might be involved in the suppression.…”

Section: Protective Effects Of Helminths Against Immunological Dismentioning

confidence: 99%

Parasitic Helminths: New Weapons against Immunological Disorders

Osada

Kanazawa

2010

Journal of Biomedicine and Biotechnology

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The prevalence of allergic and autoimmune diseases is increasing in developed countries, possibly due to reduced exposure to microorganisms in childhood (hygiene hypothesis). Epidemiological and experimental evidence in support of this hypothesis is accumulating. In this context, parasitic helminths are now important candidates for antiallergic/anti-inflammatory agents. Here we summarize antiallergic/anti-inflammatory effects of helminths together along with our own study of the effects of Schistosoma mansoni on Th17-dependent experimental arthritis. We also discuss possible mechanisms of helminth-induced suppression according to the recent advances of immunology.

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“…Ascaris lumbricoides infections in endemic regions were associated with a highly polarized Th2 cytokine response . Generation of regulatory T cells (Tregs) in the liver and blood was observed during ascariasis (Matera et al 2008;Dawson et al 2009). The anti-A.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulation of liver injury by Ascaris suum extract in an experimental model of autoimmune hepatitis

et al. 2014

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Adult worm extract from Ascaris suum (Asc) has immunosuppressive activity and elicits Th2/IL-4/IL-10 response. This study evaluated the prophylactic and therapeutic effect of Asc in a murine model of concanavalin A (ConA)-induced autoimmune hepatitis (AIH). BALB/c mice received ConA, iv, (20 mg/kg), and three groups of animals were formed: (1) AIH, received only ConA; (2) AIH + Asc prophylactic, treated with Asc (1 mg/ml), ip, 30 min before of the AIH; and (3) AIH + Asc therapeutic, treated with Asc 2 h after the AIH. Plasma transaminase and immunoglobulins (measured at 8 and 24 h and 7 days after treatment) and cytokine production (IL-4, IL-10, IL-13, and IFN-γ) by splenocytes upon ConA and Asc stimulus were compared. The livers were weighed and examined histologically. In the AIH group, there was an increase in liver weight, transaminase levels, and total immunoglobulins. These parameters were reduced by 8-24 h and 7 days in the prophylactic group, but in the therapeutic group, only on day 7. The survival rate of mice in the AIH group was 38.5%, compared to 67% in the therapeutic Asc group. The survival rate of the animals with AIH that were prophylactically treated with Asc was 100%. A decrease of cellular infiltration and high levels of IL-4, IL-10, and IL-13 were induced by Asc. An increase of liver fibrosis was also observed, but with less intensity with prophylactic treatment. Thus, the Ascaris components have an inhibitory effect on AIH, with an intense Th2 immune response.

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Ascaris lumbricoides-induced suppression of total and specific IgE responses in atopic subjects is interleukin 10-independent and associated with an increase of CD25+ cells

Cited by 20 publications

References 15 publications

Ascaris lumbricoides infection in urban schoolchildren: Specific IgE and IL-10 production

Ascaris lumbricoides infection in urban schoolchildren: Specific IgE and IL-10 production

Parasitic Helminths: New Weapons against Immunological Disorders

Immunomodulation of liver injury by Ascaris suum extract in an experimental model of autoimmune hepatitis

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