Ascaris and Malnutrition in a Group of Brazilian Children--A Follow-up Study

Kloetzel, Kurt; Filho, TIRçO José Merluzzi; Kloetzel, Daniel

doi:10.1093/tropej/28.1.41

Cited by 26 publications

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“…In fact, after 18 months the mebendazole group showed a significantly smaller increase in weight-for-age (ANOVA p <0-05) and a significantly greater deterioration in weight-for-height (ANOVA p<0.001) compared with the placebo group. Unlike previous studies (Greenberg et al 1981, Gupta and Urrutia 1982, Kloetzal et al 1982, the negative results from this study cannot be attributed to unsatisfactory removal of worms in the mebendazole group.…”

Section: Discussioncontrasting

confidence: 99%

An 18-month study of the effect of periodic anthelminthic treatment on the growth and nutritional status of pre-school children in Bangladesh

Rousham

Mascie‐Taylor

1994

Annals of Human Biology

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An 18-month study was conducted from February 1989 to August 1990 to examine the effect of regular deworming on child growth and nutritional status. A sample of 1402 children, from 2 to 6 years old, were divided into a treatment group and a control group. The 688 children in the treatment group received a 500 mg single dose of mebendazole, while the 714 children in the control group were given a placebo. Height, weight and mid-upper arm circumference (MUAC) were measured on monthly household visits. Growth was measured in terms of the change in height-for-age, weight-for-age, weight-for-height and MUAC over 18 months. The initial prevalence of infection was estimated from a random sample of 96 children (49 treated, 47 control). The initial overall prevalence of Ascaris lumbricoides, Trichuris trichiura and hookworm was 71, 44 and 10% respectively. The final prevalence of infection, estimated from a random sample of 265 children, was A. lumbricoides 6%, T. trichiura 6% and hookworm 2% in the mebendazole group compared with 64, 18 and 19% respectively in the placebo group. Despite the successful treatment of helminths, there was no significant improvement in the growth of treated children compared with their untreated counterparts in terms of the change in z-scores of height-for-age, weight-for-age, weight-for-height and MUAC. The factors which may have contributed to this outcome are discussed.

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Section: Discussioncontrasting

confidence: 99%

An 18-month study of the effect of periodic anthelminthic treatment on the growth and nutritional status of pre-school children in Bangladesh

Rousham

Mascie‐Taylor

1994

Annals of Human Biology

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“…As a general rule, loss to follow up was calculated on the basis of measurements at the final testing time. In five studies the degree of loss to follow up was unclear 21 22 25 27 30. Eight studies had a loss to follow up of less than 10%, while in 15 it was between 10% and 35%.…”

Section: Methodsmentioning

confidence: 99%

Effects of treatment for intestinal helminth infection on growth and cognitive performance in children: systematic review of randomised trials

Dickson

Awasthi²,

Williamson³

et al. 2000

BMJ

184

130

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Objective To summarise the effects of anthelmintic drug treatment on growth and cognitive performance in children. Results Thirty randomised controlled trials in more than 15 000 children were identified. Effects on mean weight were unremarkable, and heterogeneity was evident in the results. There were some positive effects on mean weight change in the trials reporting this outcome: after a single dose (any anthelmintic) the pooled estimates were 0.24 kg (95% confidence interval 0.15 kg to 0.32 kg; fixed effects model assumed) and 0.38 kg (0.01 kg to 0.77 kg; random effects model assumed). Results from trials of multiple doses showed mean weight change in up to one year of follow up of 0.10 kg (0.04 kg to 0.17 kg; fixed effects) or 0.15 kg (0.00 to 0.30; random effects). At more than one year of follow up, mean weight change was 0.12 kg (−0.02 kg to 0.26 kg; fixed effects) and 0.43 (−0.61 to 1.47; random effects). Results from studies of cognitive performance were inconclusive. Conclusions There is some limited evidence that routine treatment of children in areas where helminths are common has effects on weight gain, but this is not consistent between trials. There is insufficient evidence as to whether this intervention improves cognitive performance. Data sources

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“…These sex-specific al. 1981, Kloetzel et al 1982). We administrated 500 mg of mebendazole every 3 mo.…”

Section: Methodsmentioning

confidence: 99%

Vitamin A Supplementation but Not Deworming Improves Growth of Malnourished Preschool Children in Eastern Zaire

Donnen

Brasseur

Dramaix

et al. 1998

The Journal of Nutrition

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A randomized controlled trial was conducted in eastern Zaire to assess the effects of high dose vitamin A supplementation and regular deparasitation on the growth of 358 moderately malnourished preschool children, discharged from the hospital. The treatment groups received either vitamin A (60 mg of oily solution of retinyl palmitate, 30 mg if aged õ12 mo) every 6 mo or mebendazole (500 mg) every 3 mo; the control group received no supplementation. Anthropometric data were gathered at baseline and after 6 and 12 mo of followup. Serum retinol concentrations were measured at baseline and after 3 mo. The three groups did not differ in sociodemographic indicators, age and sex composition, nutritional status and serum retinol concentrations at baseline. In children who were vitamin A deficient at baseline, adjusted mean weight and mid-upper arm circumference (MUAC) increments were higher in the vitamin A-supplemented group than in the control group [annual increment in weight and MUAC in vitamin A vs. control group: 2.088 vs. 1.179 kg (P Å 0.029) and 2.24 vs. 0.95 cm (P Å 0.012), respectively], whereas growth increment did not differ between the dewormed group and the control group. In children who were not vitiamin A deficient at baseline, growth increment did not differ between the vitamin A-supplemented and control groups, whereas weight gain was lower in the dewormed group than in the control group. Vitamin A-supplemented boys gained more weight and height than control boys, whereas vitamin A-supplemented girls gained less height than control girls. Dewormed boys and girls gained less weight than control boys and girls. Programs to improve vitamin A status by high dose vitamin A supplementation may improve growth of preschool children who are vitamin A deficient, whereas deworming does not.

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Ascaris and Malnutrition in a Group of Brazilian Children--A Follow-up Study

Cited by 26 publications

References 0 publications

An 18-month study of the effect of periodic anthelminthic treatment on the growth and nutritional status of pre-school children in Bangladesh

An 18-month study of the effect of periodic anthelminthic treatment on the growth and nutritional status of pre-school children in Bangladesh

Effects of treatment for intestinal helminth infection on growth and cognitive performance in children: systematic review of randomised trials

Vitamin A Supplementation but Not Deworming Improves Growth of Malnourished Preschool Children in Eastern Zaire

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