Ascaris and ascariasis

Dold, Christina; Holland, Celia V.

doi:10.1016/j.micinf.2010.09.012

Cited by 235 publications

(217 citation statements)

References 59 publications

Supporting

Mentioning

197

Contrasting

Unclassified

Order By: Relevance

“…Intestinal parasites are invasive, they require living space and in many cases, they physically harm the intestine. For instance, A. lumbricoides penetrates through the gut and migrates to the bloodstream causing tissue injury that might trigger an immune response in the gut 48. In contrast, the association of E. coli with faecal leucocytes is unexpected, as E. coli is considered a “non‐pathogenic” protozoa.…”

Section: Discussionmentioning

confidence: 99%

Intestinal parasites: Associations with intestinal and systemic inflammation

Zavala

García

Camacho

et al. 2018

Parasite Immunology

View full text Add to dashboard Cite

SummaryThe aim of the present study was to evaluate associations between intestinal parasitic infection with intestinal and systemic inflammatory markers in school‐aged children with high rates of obesity. Plasma concentrations of C‐Reactive Protein (CRP), leptin, TNF‐α, IL‐6 and IL‐10 were measured as systemic inflammation markers and count of stool leukocytes as marker of intestinal inflammation in 291 children (6‐10 years). Intestinal parasitic infection was measured by stool examination. Logistic regression analyses were performed to determine the odds of having high inflammatory markers for each parasite or group of parasites as compared to parasite‐free children while adjusting for sex, age, mother's educational level and percentage of body fat. The prevalence of soil‐transmitted helminths and intestinal protozoa infections was 12% and 36%, respectively. Parasitic infection was not associated with CRP, IL‐6, IL‐10 or TNF‐α. Children infected with Ascaris lumbricoides (aOR: 5.91, 95% CI: 1.97‐17.70) and Entamoeba coli (aOR: 8.46, 95% CI: 2.85‐25.14) were more likely to have higher stool leucocytes than parasite‐free children. Children with multiple infections (aOR: 10.60, 95% CI: 2.85‐25.14) were more likely to have higher leptin concentrations than parasite‐free children. Intestinal parasitic infection was not associated with systemic inflammation, but was associated with intestinal inflammation. Having multiple infections were associated with higher leptin concentrations.

show abstract

Section: Discussionmentioning

confidence: 99%

Intestinal parasites: Associations with intestinal and systemic inflammation

Zavala

García

Camacho

et al. 2018

Parasite Immunology

View full text Add to dashboard Cite

show abstract

“…lumbricoides is known as a largest intestinal nematode of human. Nevertheless, in the past, ascariasis had a considerable prevalence particularly in areas which were utilized Night soil (human feces and urine) as fertilizer on food crops, thanks to improved sanitation and hygiene facilities, in the recent decades the prevalence of ascariasis has taken a nosedive progress (Dold and Holland 2011).…”

Section: Discussionmentioning

confidence: 99%

“…This nematode has a cosmopolitan distribution and 1.27 billion persons, almost one-quarter of the globe population are infected with this parasite particularly those people who are living in the developing countries especially in tropical and subtropical areas. The reasons for this predisposition may originate from social, behavioral, environmental features that poor hygienic conditions share substantial portion of infection (Dold and Holland 2011).…”

Section: Introductionmentioning

confidence: 99%

“…However, wandering adult worms have been observed in other organs. Clinical manifestation of ascariasis varies from slight and unspecific symptoms to serious signs such as fatal intestinal blockage and peritonitis (Dold and Holland 2011;Lopez et al 2010). Esophagus ascariasis is a rare event and it was reported from 15-year-old boy in India and 70-year-old female in China (Gandhi et al 1999;Zheng et al 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A rare cause of dysphagia: pharyngeal ascariasis

et al. 2015

View full text Add to dashboard Cite

Ascaris lumbricoides infection distributed widely in tropical and subtropical areas, especially in the developing countries and affects more than one billion of people. Ascariasis commonly has higher infection rates compared to other parasite species and because of poor sanitation the parasite can be seen in 100 % of the population. A. lumbricoides depending on the provocation by anesthetic agents or intestines becomes hostile, such as with inflammation and obstruction, may cause migration and varies complications such as coming up to the mouth or blocking some ducts. We report a case of pharyngeal ascariasis with worm migration, in a 67-year-old woman was referred with complaints of nausea and dysphagia.

show abstract

“…The larvae incubation timing in the jejunum expected as 65 days and feeds on digestion of the host. The infected children with a marginal diet found to be susceptible to protein, caloric, or suffer from Vitamin A deficiency, which stood up in growth retardation and increases the susceptibility to malaria infection [4] and sometime in overexposed situation, it causes relative immunodeficiency [5]. In the higher infection load of this worm causes severe complication whereas, at minimal level it remains asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

Prediction of MHC Binding Peptides and Antigenic Peptides from Ascaris lumbricoides

Mishra¹,

Gomase²

2016

J Autoimmune Disord

View full text Add to dashboard Cite

The parasitic disease Ascariasis is the major concern because of its morbidity and mortality issue. In this investigation, we predicted the binding peptides of the MHC class I and MHC class II by Position Specific Scoring Matrices (PSSM) and Support Vector Machine (SVM) algorithms. We predicted the binding affinity of Cytochrome c oxidase subunit 2 (mitochondrion) having a 232 amino acids long residue sequence, which shows 224 nonamers. We predicted the peptide binding affinity to MHC I moles are as 8mer_H2_Db (The binding We also study integrates prediction of peptide MHC class I binding; proteasomal C terminal cleavage and TAP transport efficiency by using sequence and properties of the amino acids. We also found the binding of peptides to different alleles by using Position Specific Scoring Matrix. PSSM based server will predict the peptide binders of Cytochrome c oxidase subunit 2 from Ascaris lumbricoides sequence to, which are found antigenic epitopes region in protein.

show abstract

Ascaris and ascariasis

Cited by 235 publications

References 59 publications

Intestinal parasites: Associations with intestinal and systemic inflammation

Intestinal parasites: Associations with intestinal and systemic inflammation

A rare cause of dysphagia: pharyngeal ascariasis

Prediction of MHC Binding Peptides and Antigenic Peptides from Ascaris lumbricoides

Contact Info

Product

Resources

About