Ascaridole and Related Peroxides From the Genus Chenopodium

Dembitsky, Valery M.; Shkrob, Ilya A.; Hanŭs, L

doi:10.5507/bp.2008.032

Cited by 74 publications

(54 citation statements)

References 40 publications

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“…Other remarkable finding of this work was the detection of high amounts of ascaridole. The abundance of this volatile was analogous to that described for the essential oils of Chenopodium quinoa and Chenopodium betrays, plants that accumulate high endogenous levels of the anthelmintic monoterpene (Dembitsky et al, 2008). The levels of cryptone were higher in the essential oils of 2016, but, the amounts of linalool and caryophyllene oxide decreased and increased, respectively.…”

Section: Resultsmentioning

confidence: 69%

Chemical profile, nutraceutical and anti-phytobacterial properties of the essential oil from Dalea foliolosa (Fabaceae)

et al. 2017

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The present work describes the chemical composition of the leaf essential oils from the annual plant Dalea foliolosa, which was collected in three consecutive years (2014-2016). The amount of monoterpenes (69.5-84.6%) was higher to that of sesquiterpenes (10.3-22.9%) and aliphatic hydrocarbons (1-2.1%). Cryptone (22.3-30.6%) was the most abundant oxygenated monoterpene, followed by linalool (10.4-17.6%), caryophyllene oxide (4.6-15.3%), ascaridole (4.5-7.4%) and β-citronellol (3.8-5.6%). The hydrodistillated extract showed antioxidant activity against DPPH radical (IC50, 45-156 µg mL-1), strong anti-α-glucosidase activity (IC50, 14-47 µg mL-1) and inhibited the growth of Pseudomonas syringae pv. tabaci TBR2004 (MIC, 44-105 µg mL-1) and P. syringae pv. tomato DC3000 (MIC, 35-155 µg mL-1). The possible use of the essential oil as a novel additive for anti-hyperglycemic supplements and for the biological control of the analyzed Pseudomonas syringae varieties, may be contemplated.

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Section: Resultsmentioning

confidence: 69%

Chemical profile, nutraceutical and anti-phytobacterial properties of the essential oil from Dalea foliolosa (Fabaceae)

et al. 2017

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“…Ascaridole and other terpenoids were previously detected in the essential oil of C. foliosum by GC-MS analysis [8] while flavonol glycosides of patuletin, spinacetin, 6-methoxykaempferol and gomphrenol have been isolated from the methanol extract of the aerial parts [4].…”

Section: Physico-chemical Analysismentioning

confidence: 99%

Pharmacognostic investigations of the aerial parts of Chenopodium foliosum Asch. and radical-scavenging activities of five flavonoids isolated from methanol extract of the plant

Kokanova-Nedialkova¹,

Nedialkov²,

Nikolov³

2014

Phcog J.

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Background: Chenopodium foliosum Asch. also known in Bulgarian folk medicine as "garliche" or "svinski yagodi" (swine's berries) has been used as a decoct of aerial parts for treatment of cancer, as antioxidant and immunostimulant. This study was undertaken to investigate its phytochemical, physicochemical and radicalscavenging activities of the aerial parts of the plant. Materials and Methods: Physico-chemical parameters: moisture content, foaming index, total ash, dichloromethane, alcohol and water soluble extractive, pleliminary phytochemical screening and TLC finger print profile were determined. Three new flavonol glycosides, 3-O-ß-gentiobiosides of 6-methoxykaempferol and gomphrenol and a new gomphrenol trioside as well as the known 3-O-ß-gentiobiosides of patuletin and spinacetin, previously isolated from the aerial parts of Chenopodium foliosum Asch., were analyzed for radical-scavenging activity using DPPH-, ABTS-free radicals. Results: The results of physico-chemical parameters showed moisture content-6.05%, foaming index-250, total ash-12.19% and dichloromethane, alcohol and water soluble extractive respectively 2.52%, 13.20% and 12.01%. Preliminary phytochemical screening of the aerial parts of C. foliosum reveals the presence of carbohydrates, flavonoids, phytosterols, saponins and alkaloids/ amines. Patuletine-3-O-gentiobioside showed the highest DPPH (95.03 ± 0.09) and ABTS (87.20 ± 0.13) activity, compared to Vit C. 6-Methoxykaempferol-3-O-gentiobioside showed significant ABTS (81.09 ± 0.06) activity, but DPPH activity was lacking. The other flavonoids showed low DPPH activity, but moderate ABTS activity compared with BHT. Conclusion: The results of this study could be useful for correct identification of the plant and further standardization. In addition this study suggesting that the decoction prepared from C. foliosum could be a potential source of nutraceuticals with radical-scavenging activity.

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“…The species is distinguished by its constitution rich in terpenes, flavonoids, gallic tannins and alkaloids [10][11][12][13][14][15][16] . Although there are studies that attribute to C. ambrosioides a possible toxic action, allegedly resulting from the presence of the monoterpene ascaridole, constituent abundant in the specie [17][18][19] , there are also reports of no toxicological changes in treating mice with different extracts from C. ambrosioides 20,21 . So, the relevance of research on the toxicity of the species using in vitro and in vivo models is highlighted.…”

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confidence: 99%

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2015

IJPSR

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ABSTRACT:Chenopodium ambrosioides Linn, member of the National List of Medicinal Plants of Interest to SUS (RENISUS), is used to treat different diseases and shows good potential to generate products of interest to the Brazilian Unified Health System "Sistema Único de Saúde" (SUS). However, the use of herbal derivatives implies the control of their quality and the evaluation of their toxicity. Pharmacopeial tests were performed aiming at the physicochemical and microbiological characterization of leaves and extract of C. ambrosioides. The toxicity of the extract was assessed using MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) and acute toxicity was assayed in mice. The results showed that the leaves and the extract presented acceptable pharmacopeial parameters and the preliminary phytochemical analysis showed the presence mainly of saponins, terpenes, phenols and tannins in the hydroethanolic extract of C. ambrosioides. The microbiological evaluation of the extract indicated no apparent growth of pathogenic microorganisms. Although the extract showed cytotoxicity at high concentration, no signs of acute oral toxicity could be observed at the tested doses. These results, besides the partial Pharmacopeial characterization of C. ambrosioides, corroborate the literature data, regarding the cytotoxic potential. However, the results reported indicate that the use of this species is safe in appropriate doses INTRODUCTION:Medicinal plants are used in the treatment of diseases by thousands of people in the world and often represent the main and first source of health care. This form of therapeutic resource is accessible, available and culturally accepted in folk medicine 1 .

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Ascaridole and Related Peroxides From the Genus Chenopodium

Cited by 74 publications

References 40 publications

Chemical profile, nutraceutical and anti-phytobacterial properties of the essential oil from Dalea foliolosa (Fabaceae)

Chemical profile, nutraceutical and anti-phytobacterial properties of the essential oil from Dalea foliolosa (Fabaceae)

Pharmacognostic investigations of the aerial parts of Chenopodium foliosum Asch. and radical-scavenging activities of five flavonoids isolated from methanol extract of the plant

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