Ascaridole, a sensitizing component of tea tree oil, patch tested at 1% and 5% in two series of patients

Bakker, Christiaan V; Blömeke, Brunhilde; Coenraads, Pieter Jan; Schuttelaar, Marie L A

doi:10.1111/j.1600-0536.2011.01948.x

Cited by 11 publications

(11 citation statements)

References 6 publications

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“…and 5% pet., recommended testing with 2% pet. . The patch test results described in the current report support this proposal, because case 1 developed an obvious irritant reaction to ascaridole 5% (Fig.…”

Section: Discussionsupporting

confidence: 82%

Co‐sensitization to ascaridole and tea tree oil

et al. 2013

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Section: Discussionsupporting

confidence: 82%

Co‐sensitization to ascaridole and tea tree oil

et al. 2013

Self Cite

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“…Ascaridole decreases phasic contractions, reduces basal tone and contractions of rat gastrointestinal tissue in vitro induced by carbachol. Ascaridole is having unpleasant flavor and further it is shock sensitive and could be explosive [2,3]. Ascaridole have sedative, pain-relieving properties and antifungal activity because of the presence of various types of monoterpenes.…”

Section: An Overview Of Ascaridolementioning

confidence: 99%

“…HL60 (human promyelocytic leukemia cells), CCRF-CEM (human leukemia cell lines), MDA-MB-231(breast cancer cell line). Melaleuca alternifolia oil which is also known as tea tree oil showed contact allergy due to the presence of the significant amount of ascaridole [1,3].…”

Section: Introductionmentioning

confidence: 99%

A phytochemical of modern medicinal perspective

Patel¹

2017

JCLM

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“…The threshold of irritation varies between species and depends on oil composition. The cases of sensitization to various EOs: ylang-ylang (Cananga odorata) [69], tea tree [68,70], lemongrass [71], peppermint [72], lavender [73] and many other have been reported in literature. Most cases of allergy reported in Europe were caused by ylang-ylang and lemongrass essential oils as well as jasmine absolute [74].…”

Section: Safety Of Essential Oils In Topical Applicationmentioning

confidence: 99%

Application of essential oils as natural cosmetic preservatives

Dreger

Wielgus

2013

Herba Polonica

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S u m m a r yNowadays, safety of chemical preservatives has been questioned by a big number of consumers. Traditionally used preservatives often cause skin irritation and lead to allergenic reactions. Growing demands for more natural and preservative-free cosmetics promoted an idea of the replacement of synthetic preservatives with essential oils (EOs) of antimicrobial properties. The antimicrobial effect of essential oil depends on content, concentration and interactions between the main active compounds. Effective preservatives should be characterized by a broad spectrum of antimicrobial activity at a minimum concentration. Formulations containing both types of preservatives: essential oil and a synthetic one have been tested and proposed as a compromise that allows for reducing concentration of both components due to their synergistic activity. Although most essential oils are regarded as safe, some of them may cause risk of contact allergy or phototoxic reaction. A well balanced risk-benefit assessment of essential oils is one of the great challenges for scientists or health policy authorities. This paper presents current state of knowledge on essential oils focused on their antimicrobial properties, the assessment of their efficacy and safety as cosmetic preservatives.

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Ascaridole, a sensitizing component of tea tree oil, patch tested at 1% and 5% in two series of patients

Cited by 11 publications

References 6 publications

Co‐sensitization to ascaridole and tea tree oil

Co‐sensitization to ascaridole and tea tree oil

A phytochemical of modern medicinal perspective

Application of essential oils as natural cosmetic preservatives

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