Asbestosis as a precursor of asbestos related lung cancer: results of a prospective mortality study.

Hughes, Janet; Weill, Hans

doi:10.1136/oem.48.4.229

Cited by 81 publications

(70 citation statements)

References 14 publications

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“…Aqueles que trabalham com isolantes térmicos contendo o asbesto sofrem maior risco de adoecer pelo câncer do pulmão (risco relativo de aproximadamente 4%). Ainda não está perfeitamente definido se o asbesto causa o cân-cer do pulmão devido ao intenso processo de fibrose pulmonar que provoca ou se a neoplasia desenvolve-se independentemente da fibrose (44,45) .…”

Section: Iv) Asbestos E Outras Fibras Mineraisunclassified

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Epidemiologia do câncer do pulmão

Zamboni¹

2002

J. Pneumologia

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O câncer do pulmão, de doença rara no início do século XX, tornou-se a neoplasia mais letal em todo o mundo. Essa mudança se iniciou na segunda década do século, quando se observou que o número de casos vinha aumentando em todo o mundo. Somente na década de 1950 INTRODUÇÃODe doença rara no passado, o câncer do pulmão transformou-se na doença neoplásica mais comum e mais mortal, em todo o mundo. É, hoje em dia, a principal causa de morte por câncer entre os homens da América do Norte e da Europa; sua mortalidade vem aumentando, significativamente, entre as populações da Ásia, da Amé-

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Section: Iv) Asbestos E Outras Fibras Mineraisunclassified

“…O potencial carcinogênico de outras fibras, como a de vidro, a de cerâmica e outras, ainda não está bem estabelecido (45) .…”

Section: Iv) Asbestos E Outras Fibras Mineraisunclassified

Epidemiologia do câncer do pulmão

Zamboni¹

2002

J. Pneumologia

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“…likelihood (Hughes & Weill, 1991;Kiviluoto et al, 1979;Koskinen et al, 2002;Lotti, 2010;Partanen et al, 1992;Sandén & Järvholm, 1991 11 ;Thiringer et al, 1980;Wain et al, 1984). A finding that a higher proportion of subjects with pleural plaques have either lung cancer or mesothelioma compared to those who do not may reflect that fact that there is a doseresponse for plaques and subjects with plaques may simply have had greater exposure than those without plaques.…”

Section: Pleural Plaques As Markers Of Exposurementioning

confidence: 99%

Are pleural plaques an appropriate endpoint for risk analyses?

Maxim¹,

Niebo²,

Utell

2015

Inhalation Toxicology

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This review summarizes the literature on the relation between the development of pleural plaques and non-malignant and malignant disease in cohorts exposed to asbestos and other fibers. The available evidence indicates that, absent any other pleural disease, the presence of pleural plaques does not result in respiratory symptoms or clinically significant impacts on lung function. For certain types of asbestos, the development of pleural plaques is statistically correlated with malignant disease, but the evidence is consistent with the hypothesis that pleural plaques without other pleural disease are a marker of exposure, rather than an independent risk factor. Pleural plaques have also developed in cohorts exposed to other fibers that have not proven to be carcinogenic. Risk analyses should be based on the avoidance of known adverse conditions, rather than pleural plaques per se.

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“…Over the years, many researchers have remained in favor of "the asbestosis-cancer hypothesis" (6)(7)(8)(9)(10)(11)(12)(13). Gradually, however, several papers have appeared which have shown that an increased risk for lung cancer occurs also in asbestos workers without obvious asbestosis.…”

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confidence: 99%

Asbestos, asbestosis, pleural plaques and lung cancer

Hillerdal¹,

Henderson²

1997

Scand J Work Environ Health

122

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Hillerdal G, Henderson DW. Asbestos, asbestosis, pleural plaques and lung cancer. Scand J Work Environ Health 1997;23(2):93-103.Inhalation of asbestos fibers increases the risk of bronchial carcinoma. It has been claimed that asbestosis is a necessary prerequisite for the malignancy, but epidemiologic studies usually do not have enough statistical strength to prove that asbestos-exposed patients without asbestosis are without risk. Several recent studies do actually indicate that there is a risk for such patients. In addition, case-referent studies of patients with lung cancer show an attributable risk for asbestos of 6% to 23%, which is much higher than the actual occurrence of asbestosis among these patients. Thus there is an increasing body of evidence that, at low exposure levels, asbestos produces a slight increase in the relative risk of lung cancer even in the absence of asbestosis. Consequently, all exposure to asbestos must be minimized.

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Asbestosis as a precursor of asbestos related lung cancer: results of a prospective mortality study.

Abstract: A prospective mortality study of 839 men

Cited by 81 publications

References 14 publications

Epidemiologia do câncer do pulmão

Epidemiologia do câncer do pulmão

Are pleural plaques an appropriate endpoint for risk analyses?

Asbestos, asbestosis, pleural plaques and lung cancer

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