Asbestos scandal

doi:10.1038/468868a

Cited by 16 publications

(6 citation statements)

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“…The continued import of asbestos containing products as well as potential exposure to asbestos in place will be risk factors for induction of MM for decades. In addition, asbestos and erionite exposures can occur from outcrops of asbestos and erionite containing soil in certain locations of the world including the US (Maher B., 2010). Such environmental exposures must be promptly identified to prevent the risk of “disturbing” these deposits and exposing the population, as it has occurred in Cappadocia and more recently in certain areas of the US (Carbone et al, 2007; Maher B., 2010).…”

Section: Mm: a Preventable Tragedymentioning

confidence: 99%

“…In addition, asbestos and erionite exposures can occur from outcrops of asbestos and erionite containing soil in certain locations of the world including the US (Maher B., 2010). Such environmental exposures must be promptly identified to prevent the risk of “disturbing” these deposits and exposing the population, as it has occurred in Cappadocia and more recently in certain areas of the US (Carbone et al, 2007; Maher B., 2010). Finally, the presence of asbestos or “asbestos like” minerals may occur as natural components of some non-asbestos minerals exploited for various commercial applications (such as some deposits of vermiculite and talc) and in such cases it may be difficult to realize that a fibrous component exists.…”

Section: Mm: a Preventable Tragedymentioning

confidence: 99%

“…Unfortunately, the incidence of MM has not shown any sign of vanishing anywhere in the world (Hillerdall 1999; Price and Ware 2009; Moolgavkar 2009; Altekruse et al, 2010; Tan et al, 2010). While asbestos exposure in the workplace has largely been eliminated in the US and Europe, environmental exposure that result from outdoor air pollution has not and may be increasing as natural deposits of asbestos and erionite are disturbed by human activities including land development (Baumann et al, 2007; Maher B 2010). Asbestos is widespread in the environment due to previous industrial use, because asbestos is extremely difficult to remove, and because houses are built near natural geological deposits of asbestos or erionite (Baumann et al, 2007).…”

Section: Mm: a Preventable Tragedymentioning

confidence: 99%

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Malignant mesothelioma: Facts, Myths, and Hypotheses

Carbone

Dodson³

et al. 2011

Journal Cellular Physiology

324

380

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Malignant mesothelioma (MM) is a neoplasm arising from mesothelial cells lining the pleural, peritoneal, and pericardial cavities. Over 20 million people in the US are at risk of developing MM due to asbestos exposure. MM mortality rates are estimated to increase by 5-10% per year in most industrialized countries until about 2020. The incidence of MM in men has continued to rise during the past 50 years, while the incidence in women appears largely unchanged. It is estimated that about 50-80% of pleural MM in men and 20-30% in women developed in individuals whose history indicates asbestos exposure(s) above that expected from most background settings. While rare for women, about 30% of peritoneal mesothelioma in men has been associated with exposure to asbestos. Erionite is a potent carcinogenic mineral fiber capable of causing both pleural and peritoneal MM. Since erionite is considerably less widespread than asbestos, the number of MM cases associated with erionite exposure is smaller. Asbestos induces DNA alterations mostly by inducing mesothelial cells and reactive macrophages to secrete mutagenic oxygen and nitrogen species. In addition, asbestos carcinogenesis is linked to the chronic inflammatory process caused by the deposition of a sufficient number of asbestos fibers and the consequent release of pro-inflammatory molecules, especially HMGB-1, the master switch that starts the inflammatory process, and TNF-alpha by macrophages and mesothelial cells. Genetic predisposition, radiation exposure and viral infection are co-factors that can alone or together with asbestos and erionite cause MM.

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Section: Mm: a Preventable Tragedymentioning

confidence: 99%

Section: Mm: a Preventable Tragedymentioning

confidence: 99%

Section: Mm: a Preventable Tragedymentioning

confidence: 99%

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Malignant mesothelioma: Facts, Myths, and Hypotheses

Carbone

Dodson³

et al. 2011

Journal Cellular Physiology

324

380

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“…Currently, crocidolite is considered to be the most carcinogenic asbestos compound (500 times more than chrysotile), but this is still controversial. (39–41) We recently proposed that the surface of asbestos acts as a niche for oxidative modifications that can lead to the formation of oxidized DNA and proteins, such as 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal. Additionally, we identified more than 100 asbestos-interacting proteins.…”

Section: Discussionmentioning

confidence: 99%

Distinct affinity of nuclear proteins to the surface of chrysotile and crocidolite

Kubo¹,

H²,

Nagai³

et al. 2012

J. Clin. Biochem. Nutr.

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The inhalation of asbestos is a risk factor for the development of malignant mesothelioma and lung cancer. Based on the broad surface area of asbestos fibers and their ability to enter the cytoplasm and nuclei of cells, it was hypothesized that proteins that adsorb onto the fiber surface play a role in the cytotoxicity and carcinogenesis of asbestos fibers. However, little is known about which proteins adsorb onto asbestos. Previously, we systematically identified asbestos-interacting proteins and classified them into eight sub-categories: chromatin/nucleotide/RNA-binding proteins, ribosomal proteins, cytoprotective proteins, cytoskeleton-associated proteins, histones and hemoglobin. Here, we report an adsorption profile of proteins for the three commercially used asbestos compounds: chrysotile, crocidolite and amosite. We quantified the amounts of adsorbed proteins by analyzing the silver-stained gels of sodium dodecyl sulfate-polyacrylamide gel electrophoresis with ImageJ software, using the bands for amosite as a standard. We found that histones were most adsorptive to crocidolite and that chromatin-binding proteins were most adsorptive to chrysotile. The results suggest that chrysotile and crocidolite directly interact with chromatin structure through different mechanisms. Furthermore, RNA-binding proteins preferably interacted with chrysotile, suggesting that chrysotile may interfere with transcription and translation. Our results provide novel evidence demonstrating that the specific molecular interactions leading to carcinogenesis are different between chrysotile and crocidolite.

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“…The inflammatory response after intraperitoneal injection is indeed proportionally associated with mesothelial carcinogenesis and important 7. (vi) Although there may be some controversy about banning chrysotile (white asbestos with threshold and impurity issues) globally, chrysotile is carcinogenic to mesothelial cells (IARC Group 1) and should be banned as soon as possible 8. The important point is that asbestos‐induced mesothelial carcinogenesis takes a few decades.…”

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confidence: 99%