Asbestos‐like Pathogenicity of Long Carbon Nanotubes Alleviated by Chemical Functionalization

Ali‐Boucetta, Hanene; Nunes, António; Sainz, Ricardo Calle; Herrero, M. Antonia; Tian, Bowen; Prato, Maurizio; Bianco, Alberto; Kostarelos, Kostas

doi:10.1002/anie.201207664

Cited by 157 publications

(123 citation statements)

References 25 publications

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“…22,23 In this direction we recently studied the in vivo impact of different types of functionalization. 21 High levels of inammatory reaction were observed in C57Bl/6 mice when long unmodied or alkylated CNTs were intraperitoneally injected. In contrast, short CNTs functionalized with an aminoterminal TEG chain induced no inammation, revealing the importance of CNT length and surface decoration as crucial parameters to consider when designing novel carbon nanotubebased therapeutic tools.…”

Section: Drmentioning

confidence: 99%

Carbon nanomaterials as new tools for immunotherapeutic applications

2014

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Carbon-based nanomaterials, including carbon nanotubes and graphene, have gained great attention in the scientific community due to their unique physico-chemical properties, which could be also promising in many biomedical-related fields. In particular, their low cytotoxicity, achieved when properly functionalized, along with the possibility to link multiple bioactive molecules, realistically allows envisaging their potential use as a therapeutic platform. In this context, the immune system and immune responses play an important role in our organism, as they are involved either directly or indirectly in many diseases. Therefore, the possibility to prevent or block a disease by controlling and/or modulating the immune responses has become an important task in nanomedicine. In this feature article the advantages of using carbon-based materials in immunotherapy are presented. Important goals achieved using carbon nanotubes and graphene are described, highlighting the promising use of these nanomaterials in cancer treatment, imaging and vaccine development. The capacity of functionalized carbon nanotubes to modulate the immune responses is also discussed, highlighting the current state of the art and the future developments on this subject.

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Section: Drmentioning

confidence: 99%

Carbon nanomaterials as new tools for immunotherapeutic applications

2014

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“…Recently, more and more studies consistently show that pristine CNTs tend to agglomerate and accumulate in RES organs (especially liver and lungs, and, to a less extent, spleen), while fCNTs are better tolerated, to an extent that depends on the level and type of functionalization [29,37,38]. For instance, after half an hour of intravenous injection, MWCNT formulations accumulate in RES organs (especially liver and lungs) irrespective of their surface properties (i.e.…”

Section: Chemically Functionalized Cnts For Biological Applicationsmentioning

confidence: 99%

“…displaying hydrophobic octyl chains) and bundled pristine CNTs, both of which form large aggregates that behave more like asbestos (Fig. 1) [38]. Second, the level of functionalization has an impact on CNT cytotoxicity, presumably for similar reasons.…”

Section: Chemically Functionalized Cnts For Biological Applicationsmentioning

confidence: 99%

The winding road for carbon nanotubes in nanomedicine

et al. 2015

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Carbon nanotubes (CNTs) are recognized as promising nanomaterials for technological advancement. However, the stigma of structural similarity with asbestos fibers has slowed down progress of CNTs in nanomedicine. Nevertheless, it also prompted thorough studies that have revealed that functionalized CNTs (fCNTs) can biologically behave in a very different and safer manner. Here we review pristine and fCNT fate in biological settings, focusing on the importance of protein interaction, formation of the protein corona, and modulation of immune response. The emerging consensus on the desirable fCNT properties to achieve immunological neutrality, and even biodegradation, shows great promise for CNT adoption in medicine

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“…For example, they have promising applications in catalysis (Kang et al 2014;Liu et al 2014;Xiao et al 2015), electronics (Schroeder et al 2014), energy storage (Paraecattil and Banerji 2014), nano composites (Oueiny et al 2014;Reuillard et al 2014), medicine (Serrano et al 2014) due to their outstanding properties such as thermal, mechanical, electrochemical, and chemical properties, and have aroused a great research interest. However, because of strong inter-nanotube van der Waals forces (Ali-Boucetta et al 2013), and the low reactivity of sp 2 -hybridized C atoms of CNTs (Lavskaya et al 2009). CNTs easily form twisted aggregates, and difficult to complex with matrix molecules stably and evenly to form an effective combination in the preparation of composite materials.…”

Section: Introductionmentioning

confidence: 99%

Effects of functional group modification on the thermal properties of nano-carbon clusters

Cai

Yang

2015

J Nanopart Res

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In this paper, the thermal properties including thermal stability, thermal decomposition activation energy and the thermal enthalpy of nano-carbon clusters (NCCs, including fullerene[60](C 60 , with a diameter of 0.71 nm), multi-walled carbon nanotubes(MWCNTs, with a diameter of 10-30 nm and a length of 1-2 lm), single-walled carbon nanotubes (SWCNTs, with a diameter of *2 nm and a length of 5-15 lm), ligands of NCC-based terpyridine (NCC-tpy), and NCC-based ruthenium complexes (NCC-tpyRuCl 3 ) were systematically studied by method of simultaneous thermogravimetric and differential thermal analysis. The results show that the modification of NCCs with terpyridine leads to a decrease in the thermal stability and in the thermal decomposition activation energy (the thermal decomposition activation energy decreased from 174.4 for C 60 , 144.9 for MWCNTs and 161.2 kJ/mol for SWCNTs to 166.2 for C 60 -tpy, 119.7 for MWCNT-tpy and 85.0 kJ/mol for SWCNT-tpy). But the modification of NCCs with terpyridine results in an increase in the enthalpy change of NCC thermal decomposition reaction. The introduction of the metal ions through complexation further decreases the thermal stability and the thermal decomposition activation energy of NCC-tpyRuCl 3 due to the catalytic oxidation of Ru(III) ions (the activation energy decreases to 124.1 for C 60 -tpyRuCl 3 , 106.4 for MWCNT-tpyRuCl 3 and 41.2 kJ/mol for SWCNT-tpyRuCl 3 ). The introduction of the metal ions also leads to a decrease in the enthalpy change of the thermal decomposition reaction.

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Asbestos‐like Pathogenicity of Long Carbon Nanotubes Alleviated by Chemical Functionalization

Abstract: No abstrac

Cited by 157 publications

References 25 publications

Carbon nanomaterials as new tools for immunotherapeutic applications

Carbon nanomaterials as new tools for immunotherapeutic applications

The winding road for carbon nanotubes in nanomedicine

Effects of functional group modification on the thermal properties of nano-carbon clusters

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