Asbestos fibers in para‐aortic and mesenteric lymph nodes

Uibu, Toomas; Vanhala, Esa; Sajantila, Antti; Lunetta, Philippe; Mäkelä-Bengs, Päivi; Goebeler, Sirkka; Jäntti, Matti; Tossavainen, Antti

doi:10.1002/ajim.20694

Cited by 15 publications

(11 citation statements)

References 17 publications

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“…The authors also reported that the likelihood of translocation was strongly related to the thinness of the fiber [72]. Asbestos fibers have been found in mesenteric lymph nodes in autopsies of individuals with asbestos exposure [73], supporting the hypothesis that lymph drainage is an important translocation mechanism for asbestos in the human body [73,74)]. Kurimoto et al [75] reported this in a case of peritoneal mesothelioma asbestos fibers at concentrations >10,000 fibers/g dry tissue, which were found in all samples of intra-abdominal tissue examined (except in the small intestine.…”

Section: Experimental Datasupporting

confidence: 50%

Peritoneal Mesothelioma and Asbestos: Clarifying the Relationship by Epidemiology

Kanarek¹,

Mandich²

2016

Epidemiology

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Peritoneal mesothelioma has been recognized for over a half century, but causality with asbestos of different fiber types and the incidence of this fatal tumor in relation to asbestos exposure dose still needs clarification. In order to help bring clarity, the most important studies on peritoneal mesothelioma, including a brief history, relationship to asbestos exposures, diagnostic issues and experimental studies are reviewed including case series, case-control, occupational, and registry epidemiology studies. This review concludes that all types of asbestos, including amphiboles and chrysotile, are causative for peritoneal mesothelioma. Many cases have been found in both males and females from asbestos exposures in occupational and neighborhood settings, shown in differing epidemiology study designs. It is clear that there is a causal relationship between all types of asbestos at all dose levels for peritoneal mesothelioma and no threshold of exposure to asbestos appears safe.

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Section: Experimental Datasupporting

confidence: 50%

Peritoneal Mesothelioma and Asbestos: Clarifying the Relationship by Epidemiology

Kanarek¹,

Mandich²

2016

Epidemiology

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“…Several studies also report an association between asbestos exposure and periaortitis and retroperitoneal fibrosis, both of which are considered autoimmune diseases [53–57]. This pathology is of interest due to the fiber burden of tissues in this area of the body following asbestos exposure [58]. …”

Section: Systemic Autoimmune Disease (Said) and Asbestosmentioning

confidence: 99%

Autoimmunity and Asbestos Exposure

Pfau

Serve

Noonan

2014

Autoimmune Diseases

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Despite a body of evidence supporting an association between asbestos exposure and autoantibodies indicative of systemic autoimmunity, such as antinuclear antibodies (ANA), a strong epidemiological link has never been made to specific autoimmune diseases. This is in contrast with another silicate dust, crystalline silica, for which there is considerable evidence linking exposure to diseases such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. Instead, the asbestos literature is heavily focused on cancer, including mesothelioma and pulmonary carcinoma. Possible contributing factors to the absence of a stronger epidemiological association between asbestos and autoimmune disease include (a) a lack of statistical power due to relatively small or diffuse exposure cohorts, (b) exposure misclassification, (c) latency of clinical disease, (d) mild or subclinical entities that remain undetected or masked by other pathologies, or (e) effects that are specific to certain fiber types, so that analyses on mixed exposures do not reach statistical significance. This review summarizes epidemiological, animal model, and in vitro data related to asbestos exposures and autoimmunity. These combined data help build toward a better understanding of the fiber-associated factors contributing to immune dysfunction that may raise the risk of autoimmunity and the possible contribution to asbestos-related pulmonary disease.

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“…Another study indicated that asbestos fibers accumulate not only in the lung tissue but also in the retroperitoneal and mesenteric lymph nodes (Uibu et al, 2009). Results demonstrated that “even low-level occupational exposures result in the presence of crocidolite, amosite, anthophyllite, tremolite, or chrysotile in these abdominal lymph nodes.” Furthermore, it was found that the results “support the hypothesis of lymph drainage as an important translocation mechanism for asbestos in the human body.”…”

Section: Translocation Of Remp From the Lungmentioning

confidence: 99%

Morphological and Chemical Mechanisms of Elongated Mineral Particle Toxicities

Aust¹,

Cook

Dodson³

2011

Journal of Toxicology and Environmental Health, Part B

131

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Much of our understanding regarding the mechanisms for induction of disease following inhalation of respirable elongated mineral particles (REMP) is based on studies involving the biological effects of asbestos fibers. The factors governing the disease potential of an exposure include duration and frequency of exposures; tissue-specific dose over time; impacts on dose persistence from in vivo REMP dissolution, comminution, and clearance; individual susceptibility; and the mineral type and surface characteristics. The mechanisms associated with asbestos particle toxicity involve two facets for each particle's contribution: (1) the physical features of the inhaled REMP, which include width, length, aspect ratio, and effective surface area available for cell contact; and (2) the surface chemical composition and reactivity of the individual fiber/elongated particle. Studies in cell-free systems and with cultured cells suggest an important way in which REMP from asbestos damage cellular molecules or influence cellular processes. This may involve an unfortunate combination of the ability of REMP to chemically generate potentially damaging reactive oxygen species, through surface iron, and the interaction of the unique surfaces with cell membranes to trigger membrane receptor activation. Together these events appear to lead to a cascade of cellular events, including the production of damaging reactive nitrogen species, which may contribute to the disease process. Thus, there is a need to be more cognizant of the potential impact that the total surface area of REMP contributes to the generation of events resulting in pathological changes in biological systems. The information presented has applicability to inhaled dusts, in general, and specifically to respirable elongated mineral particles.

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Asbestos fibers in para‐aortic and mesenteric lymph nodes

Cited by 15 publications

References 17 publications

Peritoneal Mesothelioma and Asbestos: Clarifying the Relationship by Epidemiology

Peritoneal Mesothelioma and Asbestos: Clarifying the Relationship by Epidemiology

Autoimmunity and Asbestos Exposure

Morphological and Chemical Mechanisms of Elongated Mineral Particle Toxicities

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