Asbestos Exposure and Ovarian Cancer: A Meta-analysis

Kim, Seo Young; Chang, Ha Kyun; Kwon, Ohwi; Park, JaeYoung; Myong, Jun-Pyo

doi:10.1016/j.shaw.2023.11.002

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…According to a WHO report in 2018, about 125 million people worldwide are still exposed to asbestos in the workplace. All forms of asbestos are pathogenic (World Health Organization 2014 ) to humans and may cause diseases such as pulmonary fibrosis (Wilk and Krowczynska 2021 ), cancer (Straif et al 2009 ), (Institute of Medicine Committee on Asbestos and Selected Health Effects 2006 ; Wronkiewicz et al 2020 ; Acheson et al 1982 ; Kim et al 2024 ) especially cancer of the respiratory system (Henderson and Enterline 1979 ; Kwak et al 2022 ). A GBD study showed that global deaths attributable to occupational asbestos exposure will increase by 2035 (Miao et al 2024 ).…”

Section: Introductionmentioning

confidence: 99%

Global burden of mesothelioma attributable to occupational asbestos exposure in 204 countries and territories: 1990–2019

Chen,

Cai,

et al. 2024

J Cancer Res Clin Oncol

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Malignant mesothelioma, a rare and aggressive cancer primarily caused by occupational asbestos exposure, has a poor prognosis. This study leverages the Global Burden of Disease (GBD) 2019 dataset to analyze the burden of mesothelioma linked to occupational asbestos exposure from 1990 to 2019. The analysis includes the number of mesothelioma deaths and disability-adjusted life years (DALYs) attributable to occupational asbestos exposure, focusing on trends in age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life-year rate (ASDR) by year, age, sex, country, region, and Socio-demographic Index (SDI). In 2019, 91.7% of mesothelioma deaths and 85.2% of DALYs were attributable to occupational asbestos exposure, resulting in 26,820 (95% UI 24,312–28,622) deaths and 569,429 (95% UI 509,956–617,484) DALYs. Despite a decline in ASMR and ASDR from 1990 to 2019, the absolute number of deaths and DALYs almost doubled. The United States reported the highest number of mesothelioma deaths, while China had the highest number of DALYs. Age-specific mortality rates and DALYs decreased in the 25–74 age group but increased in the 75+ age group. In conclusion, occupational asbestos exposure remains the primary cause of mesothelioma worldwide, with an increasing number of deaths and DALYs. The highest incidence rates are observed in high-income areas, and rates are rising in low-income areas. It is crucial to raise awareness about the hazards of asbestos to reduce the global burden of mesothelioma linked to occupational exposure.

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Section: Introductionmentioning

confidence: 99%

Global burden of mesothelioma attributable to occupational asbestos exposure in 204 countries and territories: 1990–2019

Chen,

Cai,

et al. 2024

J Cancer Res Clin Oncol

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Global burden and trends of ovarian cancer attributable to occupational exposure to asbestos: A study based on 1990-2019 GBD data.

Wang,

Mao,

et al. 2024

Preprint

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Background Ovarian cancer remains a major health issue, with occupational asbestos exposure possibly contributing to its risk. We comprehensively assess the global burden of asbestos-related ovarian cancer, explore disparities, and project future trends to inform prevention strategies. Methods We evaluated deaths and disease-adjusted life years (DALYs) globally in 2019, analyzed temporal trends (1990–2019), and used the age-period-cohort (APC) model and the Bayesian age-period-cohort (BAPC) model to predict future burdens. Decomposition analysis identified drivers of burden change, and frontier analysis assessed the correlation with socio-demographic development. Results In 2019, occupational exposure to asbestos was a significant contributor to the substantial burden of ovarian cancer, exhibiting considerable disparities across age groups, Socio-demographic Index (SDI) regions, Global Burden of Disease (GBD) regions, and countries. Despite a global trend of declining age-standardized rates (ASRs) between 1990 and 2019, the absolute number of deaths and DALYs associated with asbestos-related ovarian cancer continued to rise. The APC model predicted a steady escalation in the number of deaths and DALYs from 2019 to 2030 while forecasting a decrease in the ASRs. However, contrasting results emerged from the BAPC model, which indicates that both the number of deaths and DALYs, as well as their ASRs, are anticipated to decline. Furthermore, the frontier analysis suggested that countries with higher SDI scores exhibit greater potential for reducing the disease burden. Our decomposition analysis revealed that aging and population growth were the primary drivers of the increasing disease burden, whereas epidemiological change exerted a negative influence. Conclusions Occupational exposure to asbestos is a substantial contributor to the disease burden of ovarian cancer. Success with reducing asbestos occupational exposure through regulatory policy might point the way for a stronger role for public policy on other risks in addition to continued efforts to provide information on risk factor harm to the general public.

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Asbestos Exposure and Ovarian Cancer: A Meta-analysis

Cited by 2 publications

References 40 publications

Global burden of mesothelioma attributable to occupational asbestos exposure in 204 countries and territories: 1990–2019

Global burden of mesothelioma attributable to occupational asbestos exposure in 204 countries and territories: 1990–2019

Global burden and trends of ovarian cancer attributable to occupational exposure to asbestos: A study based on 1990-2019 GBD data.

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