Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: Case series and review of the literature

Meisenkothen, Christopher; Mm, Finkelstein

doi:10.13172/2052-0077-2-2-424

Cited by 4 publications

(16 citation statements)

References 18 publications

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“…The true incidence of asbestos exposure in these reported MMTVT cases is underestimated because of insufficient information, especially for the earlier cases and case series described until the beginning of the 2000s, when the scientific community became aware of the risk factors for this disease represented by asbestos exposure [158]. Similarly, because of the long latency period, even over decades, poor patient recall in the reconstruction of asbestos exposure and occupational histories or the patient being unaware of using materials containing asbestos [171], until now, the quality of these data was quite unclear, which might have caused the majority of MMTVT cases to date appearing to be idiopathic, and there is no accurate assessment of asbestos exposure association.…”

Section: Discussionmentioning

confidence: 99%

Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (southern Italy) mesothelioma register

et al. 2019

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Background Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is a rare disease with a poor prognosis. The diagnosis and management of these lesions are often difficult for pathologists, surgeons, oncologists and occupational physicians. A preoperative diagnosis of malignancy is rarely made, and there is no established effective therapy except orchidectomy. Methods A systematic literature review was conducted among the articles published in the English literature on primary MMTVT. Moreover four cases from the Apulia mesothelioma register are reported here. Results Two hundred eighty-nine cases of MMTVT have been reported from 1943 to 2018. Overall asbestos exposure has been investigated only for 58% of all cases reported in this review, while in 41.8% this data are not available. Noteworthy is the fact that in many reports there is not an anamnestic reconstruction of any asbestos exposure. A history of direct occupational, environmental or familial asbestos exposure is found in 27.6% of the cases. The four cases from the Apulia mesothelioma register are all with ascertained occupational exposure to asbestos. Conclusions The true incidence of asbestos exposure in MMTVT is underestimated because of insufficient information reported in older literature. To establish a broad consensus on the causal relationship between asbestos and MMTVT in the scientific community its necessary to analyze the same variables in the epidemiological studies. In general it should be recommended that a positive history of exposure to asbestos or to asbestos–containing materials are at risk for the development of a MMTVT and should be monitored.

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Section: Discussionmentioning

confidence: 99%

Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (southern Italy) mesothelioma register

et al. 2019

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“…Despite international health institutes' and agencies' recommendations (4-7), currently 2 000 000 tons of asbestos per year are still produced worldwide (8,9). Pericardial and tunica vaginalis of testis (TVT) MM accounted for around 1% of cases in the available MM case series (10)(11)(12)(13). Incidence and survival for these forms have seldom been reported.…”

mentioning

confidence: 99%

“…The causal role of asbestos exposure in pericardial and TVT MM aetiology has been considered as plausible, but no epidemiological analytical study ever tested the asbestos (or other putative risk factors) role for these diseases (11,12,15,16). Italy is one of the countries more widely involved in the current epidemic of asbestos-related diseases due to the large use of asbestos in the past and the number of exposed individuals among workers (and in the general population) until the asbestos ban issued in 1992 (17)(18)(19)(20).…”

mentioning

confidence: 99%

Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case–control study and epidemiological remarks

Marinaccio

Consonni

Mensi

et al. 2020

Scand J Work Environ Health

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“…However, the first description of MTVT associated with asbestos was held by Fligiel and Kaneko in 1976 4. MTVT might be considered to be a variation of peritoneal mesothelioma, since the peritoneal lining extends into the scrotal sac 3 , 5. Since the description of Fligiel and Kaneko4 the association of MTVT and asbestos exposure has been widely reported 6 - 11.…”

Section: Discussionmentioning

confidence: 99%

“…This association was noted to occur between 34% and 42% of the cases,8 , 9 although this is considered to be underestimated because of insufficient clinical information. The failure of a patient to report a history of asbestos exposure does not necessarily mean that no exposure occurred as many individuals may not know that they have been exposed in the workplace or in the community 3. According to some studies, family exposure to asbestos increases the risk of pleural mesothelioma by 10 times 12.…”

Section: Discussionmentioning

confidence: 99%

Malignant paratesticular mesothelioma

Fonseca¹,

Marques²,

Takahashi³

et al. 2014

ACR

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Mesothelioma of the tunica vaginalis testis (MTVT) is a rare tumor that usually affects patients after the sixth decade of life. Exposure to asbestos is a known risk factor. Enlargement of the scrotal volume is the most common initial clinical manifestation, and about 15% of cases present metastasis at diagnosis. The treatment relies on surgical resection while the role of adjuvant chemotherapy and radiotherapy remains unclear. The prognosis for patients is generally poor, with a lethal outcome in 30% over a 24-month period. The authors report a case of a 62-year-old patient with the diagnosis of MTVT without a history of asbestos exposure. After surgical treatment, metastatic disease ensued. Chemotherapy was initiated, but could not be continued due to marked and fast clinical deterioration. The authors call attention to the difficulty of early diagnosis of MTVT due to a nonspecific clinical picture, the lack of action by the patient when the scrotal enlargement was first noticed, and the lack of tumor markers. Delayed diagnosis is definitely related to unfavorable prognosis.

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Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: Case series and review of the literature

Abstract: peritoneal mesothelioma and shares similar asbestos causation.

Cited by 4 publications

References 18 publications

Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (southern Italy) mesothelioma register

Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (southern Italy) mesothelioma register

Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case–control study and epidemiological remarks

Malignant paratesticular mesothelioma

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