Asbestos exposure and benign asbestos diseases in 772 formerly exposed workers: Dose–response relationships

Mastrangelo, Giuseppe; Ballarin, Maria Nicoletta; Bellini, E.; Bicciato, Fabio; Zannol, F; Gioffrè, Francesco; Zedde, A; Tessadri, Gianna; Fedeli, Ugo; Valentini, F; Scoizzato, Luca; Marangi, G; Lange, John H.

doi:10.1002/ajim.20713

Cited by 33 publications

(25 citation statements)

References 22 publications

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“…Numerous studies have examined the dose-or exposureresponse relation for pleural plaques (Bar-Shai et al, 2012;Boffetta, 1998;Clin et al, 2011;Eisenhawer et al, 2014;Ehrlich et al, 1992;Finkelstein & Vingilis, 1984;Hosoda et al, 2008;Jakobsson et al, 1995;Järvholm, 1992;Karjalainen et al, 1994;Lockey et al, 2015;Mastrangelo et al, 2009;McDonald et al, 1986;Moolgavkar et al, 2014;Paris et al, 2008Paris et al, , 2009Rohs et al, 2008;Sandén & Järvholm, 1986;Shepherd et al, 1997;Soulat et al, 1999;Van Cleemput et al, 2001). Results differ among these studies, 6 but exposure variables found relevant in one or more studies include time since first exposure (TSFE), age at first exposure (Jones, 1997), type (Hillerdal, 1997;Jones, 1997;Sandén & Järvholm, 1986) and dimensions of fiber (Hillerdal, 1997;Jones, 1997), lung fiber burden (Karjalainen et al, 1994;Roberts, 1971), duration of exposure, intensity of estimated asbestos exposure and cumulative exposure (measured in various ways).…”

Section: Dose-or Exposure-response and Pleural Plaquesmentioning

confidence: 99%

Are pleural plaques an appropriate endpoint for risk analyses?

Maxim¹,

Niebo²,

Utell

2015

Inhalation Toxicology

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This review summarizes the literature on the relation between the development of pleural plaques and non-malignant and malignant disease in cohorts exposed to asbestos and other fibers. The available evidence indicates that, absent any other pleural disease, the presence of pleural plaques does not result in respiratory symptoms or clinically significant impacts on lung function. For certain types of asbestos, the development of pleural plaques is statistically correlated with malignant disease, but the evidence is consistent with the hypothesis that pleural plaques without other pleural disease are a marker of exposure, rather than an independent risk factor. Pleural plaques have also developed in cohorts exposed to other fibers that have not proven to be carcinogenic. Risk analyses should be based on the avoidance of known adverse conditions, rather than pleural plaques per se.

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Section: Dose-or Exposure-response and Pleural Plaquesmentioning

confidence: 99%

Are pleural plaques an appropriate endpoint for risk analyses?

Maxim¹,

Niebo²,

Utell

2015

Inhalation Toxicology

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“…During the same period, the average concentration of asbestos in the workplace was equal 7.2 f/ml in 772 past exposed workers in Veneto region of Italy [13]. Since in these subjects the correlations between historical exposure and benign asbestos-related diseases were consistent with those of earlier studies carried out with conventional chest x-rays, the estimates of occupational exposure to asbestos were accurate and precise [13]. Occupational exposure was about three orders of magnitude higher than exposure from natural sources.…”

Section: Discussionmentioning

confidence: 85%

“…During the 24-year history of regulation of exposure to asbestos, the time-weighted average concentration was ((12×2) + (5×9) + (2×13))/24, equal to 7.7 f/ml [12]. During the same period, the average concentration of asbestos in the workplace was equal 7.2 f/ml in 772 past exposed workers in Veneto region of Italy [13]. Since in these subjects the correlations between historical exposure and benign asbestos-related diseases were consistent with those of earlier studies carried out with conventional chest x-rays, the estimates of occupational exposure to asbestos were accurate and precise [13].…”

Section: Discussionmentioning

confidence: 99%

Urinary asbestos fibers and inorganic particles in past asbestos workers

Zaina

Mastrangelo

Ballarin

et al. 2014

Archives of Environmental & Occupational Health

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To assess the validity of the procedure as test of exposure to asbestos, we compared urinary asbestos fibers with occupational and environmental exposure data in a random sample of 48 patients. Occupational and environmental asbestos exposure were estimated on questionnaire, pleural plaques were diagnosed with computed tomography, inorganic fibers and particles were identified by scanning electron microscope with an energy dispersive spectrometry. Few urinary asbestos fibers (in 15% of workers and in 17% of cases with pleural plaques) and high amount of urinary silicate (particularly nonfibrous particles) were detected. Asbestos undergoes dissolution in lung tissues but the secondary minerals are largely unknown. These materials, possibly nonfibrous silicates or metals, could be excreted with urine. Therefore, another study including a control group is warranted to discriminate the occupational origin of minerals in the urine.

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“…Asbestos health monitoring guidelines were published by the Spanish Health Minister in 2003 (24) and by French Haute Autoritè de Santè in 2010 (25). In Italy a consensus document developed by experts was developed in 2012 (13) after several experiences carried out in the previous two decades (5,7,(26)(27)(28)(29)(30)(31)(32)(33). Anyhow, official specific recommendations of the Italian Health Minister are not available yet.…”

Section: Discussionmentioning

confidence: 99%

Health surveillance for former asbestos exposed worker: a specific programme developed in an Italian region

Chellini¹,

Battisti²,

Cristaudo³

et al. 2018

J. Thorac. Dis.

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Asbestos-related diseases usually have a long latency since first exposure and this legitimates a health surveillance programme addressed to asbestos workers after the cessation of their occupational exposure. After a brief history of health surveillance initiatives performed in Italy as well as in other countries, we describe a regional programme for former asbestos-exposed workers, focusing on organizational features.A regional group of experts defined its operational and economical aspects. The Regional Council supported the whole programme, making it free of charge for all subjects who fulfil the predefined enrolment criteria (being resident in the region, being younger than 80 years old with cessation of occupational asbestos exposure within the last 30 years). The programme activities are classified in two levels: a first level for a basic health evaluation and a second level for in-depth analyses. In order to guarantee an homogeneous delivery in the whole region, the programme has to be performed by public health services with a quality control of activities. The involvement of specific public health services and the cooperation of social stakeholders are expected to play a major role in overcoming still open critical issues, such as the lack of programme existence awareness and adhesion, the correct stratification of subjects for the follow-up, and the real homogeneous delivery of the health surveillance in whole region.

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Asbestos exposure and benign asbestos diseases in 772 formerly exposed workers: Dose–response relationships

Abstract: Parenchymal asbestosis and PP are associated with different aspects of asbestos exposure. DPT appears to be less specific for asbestos exposure.

Cited by 33 publications

References 22 publications

Are pleural plaques an appropriate endpoint for risk analyses?

Are pleural plaques an appropriate endpoint for risk analyses?

Urinary asbestos fibers and inorganic particles in past asbestos workers

Health surveillance for former asbestos exposed worker: a specific programme developed in an Italian region

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