Asbestos Disease in United States Shipyards*

Selikoff, Irving J.; Lilis, Ruth; Nicholson, William J.

doi:10.1111/j.1749-6632.1979.tb18732.x

Cited by 98 publications

(54 citation statements)

References 26 publications

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“…Pulmonary fibrosis is also observed in genetic disorders with pleiotropic presentation including HermanskyPudlak syndrome (14), neurofibromatosis (15), tuberous sclerosis (16), Neimann-Pick disease (17), Gaucher disease (18), familial hypocalciuric hypercalcemia (19), and familial surfactant protein C mutation (20). Finally, variability in the development of pulmonary fibrosis in response to fibrogenic agents has been reported in workers exposed to similar concentrations of asbestos (21,22) as well as in inbred strains of mice challenged with either asbestos (23,24) or bleomycin (25,26). We have reported more than 100 families with two or more cases of IIP and found that familial IIP is pleiotropic and appears to be caused by an interaction between a specific environmental exposure and a gene (or genes) that predisposes to the development of several subtypes of IIP (7).…”

Section: What This Study Adds To the Fieldmentioning

confidence: 99%

Gene Expression Profiling of Familial and Sporadic Interstitial Pneumonia

Yang

Burch

Steele

et al. 2007

Am J Respir Crit Care Med

155

125

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Rationale: Idiopathic interstitial pneumonia (IIP) and its familial variants are progressive and largely untreatable disorders with poorly understood molecular mechanisms. Both the genetics and the histologic type of IIP play a role in the etiology and pathogenesis of interstitial lung disease, but transcriptional signatures of these subtypes are unknown. Objectives: To evaluate gene expression in the lung tissue of patients with usual interstitial pneumonia or nonspecific interstitial pneumonia that was either familial or nonfamilial in origin, and to compare it with gene expression in normal lung parenchyma. Methods: We profiled RNA from the lungs of 16 patients with sporadic IIP, 10 with familial IIP, and 9 normal control subjects on a whole human genome oligonucleotide microarray. Results: Significant transcriptional differences exist in familial and sporadic IIPs. The genes distinguishing the genetic subtypes belong to the same functional categories as transcripts that distinguish IIP from normal samples. Relevant categories include chemokines and growth factors and their receptors, complement components, genes associated with cell proliferation and death, and genes in the Wnt pathway. The role of the chemokine CXCL12 in disease pathogenesis was confirmed in the murine bleomycin model of lung injury, with C57BL/6 CXCR4؉/؊ mice demonstrating significantly less collagen deposition than C57BL/6 CXCR4؉/؉ mice. Whereas substantial differences exist between familial and sporadic IIPs, we identified only minor gene expression changes between usual interstitial pneumonia and nonspecific interstitial pneumonia. Conclusions: Taken together, our findings indicate that differences in gene expression profiles between familial and sporadic IIPs may provide clues to the etiology and pathogenesis of IIP.

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Section: What This Study Adds To the Fieldmentioning

confidence: 99%

Gene Expression Profiling of Familial and Sporadic Interstitial Pneumonia

Yang

Burch

Steele

et al. 2007

Am J Respir Crit Care Med

155

125

View full text Add to dashboard Cite

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“…Several studies on asbestos disease in shipyard workers [25][26][27][28] have shown that the occurrence of mesothelioma requires a long latency period, averaging 33 yr 26,27,29) . Persons with short latency intervals contribute little information about the risk of mesotheliomas.…”

Section: Discussionmentioning

confidence: 99%

Mortality among Former Shipbreaking Workers—A 13‐Year Retrospective Follow‐up Study in Taiwan

Liu

Yang

et al. 2003

Journal of Occupational Health

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Mortality among Former Shipbreaking Workers – A 13‐Year retrospective Follow‐up Study in Taiwan: Yi‐Kuen Liu, et al. Institute of Environmental Health, National Taiwan University College of Public Health, Taiwan—This study examined the mortality among shipbreaking workers from 1985 to 1997, after the shipbreaking industry was banned in 1985–1986. The study cohort consisted of men including 2,850 flame cutters, 871 lifters, 240 oddjobbers and 225 other workers registered in 1985 at Kaohsiung Shipbreaking Workers Union. Mortality (n=336) data examined were obtained from the Vital Statistics Registry from January 1985 to December 1997. The standardized mortality ratio (SMR) and logistic regression were used to estimate the risk of mortality from neoplasms, injuries and other causes. Compared to the local reference population, the deaths that were significantly higher than the expected numbers among all workers included deaths from all cumulative causes (SMR=1.11, 95% confidence interval (CI)=1.00–1.23), and deaths from external causes of injury and poisoning (SMR=1.75, 95% CI =1.47–2.09). Flame cutters in the youngest group, on the other hand, had very significant excess deaths from nasopharynx neoplasm (SMR=5.2, 95% CI=1.7–16.2) and pleural neoplasm (SMR=104.1, 95% CI=14.0– 739.0). Based on logistic regression analysis controlling for age, lifters was about 5.1 more likely times than flame cutters to die from accidental falls. This study suggests that former shipbreaking workers are more likely to be at higher risk of injuries and the young flame cutters are at higher risk from neoplasms.

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“…Excess mortality among asbestos workers, especially from lung cancer, has been shown in many earlier studies (4,14,15,16,17,22,23). Other types of cancer, such as malignant mesotheliomas of the pleura and peritoneum, laryngeal and ovarial carcinomas, and neoplasias of the gastrointestinal tract, may also be related to asbestos exposure (2).…”

mentioning

confidence: 99%

Clinical features, mortality and survival of patients with asbestosis.

Huuskonen¹

1978

Scand J Work Environ Health

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Asbestos Disease in United States Shipyards*

Cited by 98 publications

References 26 publications

Gene Expression Profiling of Familial and Sporadic Interstitial Pneumonia

Gene Expression Profiling of Familial and Sporadic Interstitial Pneumonia

Mortality among Former Shipbreaking Workers—A 13‐Year Retrospective Follow‐up Study in Taiwan

Clinical features, mortality and survival of patients with asbestosis.

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