Asbestos content in the lymph nodes of nonoccupationally exposed individuals

Dodson, Ronald F.; Huang, Ju; Bruce, James R.

doi:10.1002/(sici)1097-0274(200002)37:2<169::aid-ajim2>3.3.co;2-m

Cited by 6 publications

(9 citation statements)

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“…This study supports research by Dodson et al indicating that asbestos fibers are found more often in the thoracic lymph nodes than the lung tissues after occupational [1] as well as non-occupational exposures [17]. The analyses conducted by Dodson et al used electron microscopy to measure the asbestos fibers in tissues and showed that the relative ratio of asbestos fibers in the thoracic lymph nodes was about 10 times higher than that in the lung tissues.…”

Section: Discussionsupporting

confidence: 89%

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Elemental and immunohistochemical analysis of the lungs and hilar lymph node in a patient with asbestos exposure, a pilot study

Koga

Satoh

Kaira

et al. 2016

Environ Health Prev Med

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Section: Discussionsupporting

confidence: 89%

“…5). Fibers in lungs may be drained into the lymphatic nodes, and the decrease in the concentration of fibers in lungs and the shortening of fibers in lymph nodes might occur over a period [17].…”

Section: Discussionmentioning

confidence: 99%

Elemental and immunohistochemical analysis of the lungs and hilar lymph node in a patient with asbestos exposure, a pilot study

Koga

Satoh

Kaira

et al. 2016

Environ Health Prev Med

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“…However, many studies have shown the existence of asbestos bodies, fibers of asbestos coated with an iron-rich material, in regional lymph nodes [31,32]. It has also been reported that nonoccupationally and occupationally asbestos-exposed individuals have asbestos in their lymph nodes [33][34][35]. Therefore, it is probable that NK cells suffer the harmful effects of asbestos in lymph nodes as well as in the lungs.…”

Section: Discussionmentioning

confidence: 99%

Altered functions of alveolar macrophages and NK cells involved in asbestos-related diseases

Nishimura

Maeda

Kumagai-Τakei

et al. 2013

Environ Health Prev Med

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Asbestos exposure causes asbestosis and malignant mesothelioma, disorders which remain difficult to cure. We focused on alveolar macrophages (AM) and natural killer (NK) cells in asbestosis and mesothelioma, respectively, and examined their functions upon exposure to asbestos or in patients with mesothelioma. Exposure to asbestos caused rat AM to exhibit high production of transforming growth factor-beta (TGF-b) with prolonged survival in the absence of other cells, not simultaneously with the apoptosis caused by asbestos. The NK cell line showed impaired cytotoxicity with altered expression of activating receptors upon exposure to asbestos, and primary NK cells in culture with asbestos and peripheral blood NK cells in mesothelioma shared a decrease in expression of NKp46, a representative activating receptor. The AM finding indicates that AM contribute to asbestosis by playing a direct role in the fibrogenic response, as well as the inflammatory response. The response of NK cells indicates that exposure to asbestos has an immune-suppressive effect, as well as a tumorigenic effect. Our studies therefore reveal novel effects of asbestos exposure on AM and tumor immunity, which may represent valuable information for construction of a strategy for prevention and cure of asbestosis and malignant mesothelioma.

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“…Therefore, it is reasonable to assume that the immune system plays a role in protecting the body from malignant mesothelioma following exposure to asbestos and that the immune system must be subject to some kind of impairment prior to the development of mesothelioma. In fact, inhaled particles and fibers reach draining lymph nodes, and it has been reported that people exposed to asbestos occupationally or nonoccupationally showed accumulation of asbestos fibers in their lymph nodes [10,11]. It is possible for asbestos to accumulate in the body slowly at low doses of exposure, thus subjecting immune cells to chronic asbestos exposure.…”

Section: Introduction: Immune System As a Key Player In Malignant Mesmentioning

confidence: 99%

Suppressed Immune System Caused by Exposure to Asbestos and Malignant Mesothelioma

Nishimura¹,

Kumagai-Τakei²,

Lee³

et al. 2020

Asbestos-Related Diseases

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Mesothelioma is the most serious of the asbestos-related diseases. It is caused by exposure to relatively low doses of asbestos and takes a long period to develop, which suggests the enactment of gradual adverse effects other than cellular toxicity. The immune system, which can play a role in tumor prevention, is a presumable target of asbestos by accumulation in lymph nodes and then slowly affecting functions of immune cells. Here, we describe key findings obtained from our studies concerning the immune-suppressive effects of asbestos and functional alteration in immune cells of patients with mesothelioma as well as plaque-positive subjects. Asbestos exposure of cell cultures resulted in decreased natural and acquired cytotoxicity exerted by NK cells and CTLs and the ability of Th1 cells to activate and support antitumor immunity. In contrast, asbestos exposure augmented Treg cell function and generation of fibrogenic/suppressive macrophages. Mesothelioma patients also showed similar characteristics in certain alterations caused by asbestos exposure. Additionally, our recent study established immunological screening devices for mesothelioma and asbestos exposure on the basis of comprehensive analysis of peripheral blood. Those findings underscore the importance of the immunological effects of asbestos and should assist further understanding of the mechanism and early detection of mesothelioma.

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Asbestos content in the lymph nodes of nonoccupationally exposed individuals

Cited by 6 publications

References 0 publications

Elemental and immunohistochemical analysis of the lungs and hilar lymph node in a patient with asbestos exposure, a pilot study

Elemental and immunohistochemical analysis of the lungs and hilar lymph node in a patient with asbestos exposure, a pilot study

Altered functions of alveolar macrophages and NK cells involved in asbestos-related diseases

Suppressed Immune System Caused by Exposure to Asbestos and Malignant Mesothelioma

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