Asbestos and mesothelioma: Worldwide trends

Kazan-Allen, Laurie

doi:10.1016/j.lungcan.2005.03.002

Cited by 136 publications

(97 citation statements)

References 7 publications

(5 reference statements)

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“…Asbestos is a group of natural fibrous minerals that reveal unique properties such as heat-, acid-, and friction-resistance with versatility and low cost for industrial use. Thus, these materials were used all over the world throughout the twentieth century and are not yet banned legally in the developing countries (5,6). Because of the long latency period (30-40 years) after asbestos exposure, the number of patients with mesothelioma is estimated to increase in most of the countries.…”

Section: Introductionmentioning

confidence: 99%

Deferasirox Induces Mesenchymal–Epithelial Transition in Crocidolite-Induced Mesothelial Carcinogenesis in Rats

Nagai

Okazaki

Chew

et al. 2013

Cancer Prevention Research

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Asbestos was used worldwide in huge quantities in the past century. However, because of the unexpected carcinogenicity to mesothelial cells with an extremely long incubation period, many countries face this long-lasting social problem. Mesothelioma is often diagnosed in an advanced stage, for which no effective therapeutic protocols are yet established. We previously reported on the basis of animal experiments that the major pathology in asbestos-induced mesothelial carcinogenesis is local iron overload. Here, we undertook to find an effective strategy to prevent, delay, or lower the malignant potential of mesothelioma during asbestos-induced carcinogenesis. We used intraperitoneal injections of crocidolite to rats. We carried out a 16-week study to seek the maximal-tolerated intervention for iron reduction via oral deferasirox administration or intensive phlebotomy. Splenic iron deposition was significantly decreased with either method, and we found that Perls' iron staining in spleen is a good indicator for iron reduction. We injected a total of 10 mg crocidolite at the age of six weeks, and the preventive measures were via repeated oral administration of 25 to 50 mg/kg/d deferasirox or weekly to bimonthly phlebotomy of 4 to 10 mL/kg/d. The animals were observed until 110 weeks. Deferasirox administration significantly increased the fraction of less malignant epithelioid subtype. Although we found a slightly prolonged survival in deferasirox-treated female rats, larger sample size and refinement of the current protocol are necessary to deduce the cancer-preventive effects of deferasirox. Still, our results suggest deferasirox serves as a potential preventive strategy in people already exposed to asbestos via iron reduction. Cancer Prev Res; 6(11); 1222-30. Ó2013 AACR.

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Section: Introductionmentioning

confidence: 99%

Deferasirox Induces Mesenchymal–Epithelial Transition in Crocidolite-Induced Mesothelial Carcinogenesis in Rats

Nagai

Okazaki

Chew

et al. 2013

Cancer Prevention Research

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“…Malignant mesothelioma (MM) is an aggressive cancer of the pleura, peritoneum or pericardium strongly associated with exposure to asbestos [1][2][3]. MM usually becomes clinically apparent after a 30-to 40-year latency period following asbestos exposure [4].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, concerns were raised about asbestos exposure of New York residents and public servants such as firefighters, rescue workers, and recovery teams after the collapse of the World Trade Center on September 11, 2001 [7]. In the United Kingdom, the peak of mesothelioma deaths is expected to fall around 2020 [3]. In contrast to the diminished use of asbestos in developed countries, asbestos use in Asian and Latin American nations has become a more common trend [3].…”

Section: Introductionmentioning

confidence: 99%

“…In the United Kingdom, the peak of mesothelioma deaths is expected to fall around 2020 [3]. In contrast to the diminished use of asbestos in developed countries, asbestos use in Asian and Latin American nations has become a more common trend [3]. For this reason, it is projected that worldwide mesothelioma incidence will continue to increase in the next 10-20 years.…”

Section: Introductionmentioning

confidence: 99%

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DNA methylation profile of 28 potential marker loci in malignant mesothelioma

et al. 2007

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SummaryPatients with malignant mesothelioma (MM), an aggressive cancer associated with asbestos exposure, usually present clinically with advanced disease and this greatly reduces the likelihood of curative treatment. MM is difficult to diagnose without invasive techniques; the development of noninvasively detectable molecular markers would therefore be highly beneficial. DNA methylation changes in cancer cells provide powerful markers that are potentially detectable non-invasively in DNA shed into bodily fluids. Here we examined the methylation status of 28 loci in 52 MM tumors to investigate their potential as molecular markers for MM. To exclude candidate MM markers that might be positive in biopsies/pleural fluid due to contaminating surrounding non-tumor lung tissue/ DNA, we also examined the methylation of these markers in lung samples (age-or environmentallyinduced hypermethylation is frequently observed in non-cancerous lung). Statistically significantly increased methylation in MM vs. non-tumor lung samples was found for estrogen receptor 1 (ESR1; p=0.0002), solute carrier family 6 member 20 (SLC6A20; p=0.0022) and spleen tyrosine kinase (SYK; p=0.0003). Examination of associations between methylation levels of the 28 loci and clinical parameters suggest associations of the methylation status of metallothionein genes with gender, Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. histology, asbestos exposure, and lymph node involvement, and the methylation status of leucine zipper tumor suppressor 1 (LZTS1) and SLC6A20 with survival. NIH Public Access

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“…These financial expenditures can become even larger when treatments are postponed or canceled due to adverse effects of disease or treatment (2,3).…”

Section: Methodsmentioning

confidence: 99%