Asbestiform riebeckite (crocidolite) dissolution in the presence of Fe chelators; implications for mineral-induced disease

Werner, Andrew; Hochella, Michael F.; Guthrie, George D.; Hardy, James L.; Aust, Ann E.; Rimstidt, J. Donald

doi:10.2138/am-1995-11-1201

Cited by 50 publications

(40 citation statements)

References 22 publications

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“…As shown in Figure 1A, all chelators used in this study except ferrozine mobilized more iron from crocidolite than amosite fibers when compared on the basis of fiber (25). The general trend in iron release for different chelator solutions is in agreement with the literature after consideration of differences in incubation conditions (e.g., fiber and chelator concentrations, chelator solvent, pH, temperature, and time) (8,17,25,34).…”

Section: Discussionsupporting

confidence: 86%

“…It is not surprising that the iron content within the surface region is similar for nontreated crocidolite and amosite fibers, as their total iron contents are also similar to each other. However, the Fe/Si ratio of 0.8 measured in this and other recent studies (Gold et al, unpublished data) is significantly higher than the values of approximately 0.6 that we measured on the same fibers in previous years (31) and that were reported by Werner et al (8). Different sample preparation and XPS analysis methods can explain this discrepancy (Gold et al, in preparation).…”

Section: Iron Assodated With Asbestos Fibers After Chelator Treatmentscontrasting

confidence: 76%

“…Iron in inhaled inorganic particulates may the latter might also originate as iron contribute to, or be the direct cause of, redeposited from solution or endogenous the pathogenicity of inhaled dusts and sources (1)(2)(3)(4)(5)(6)(7)(8). Many in vivo and in vitro fibers.…”

Section: Introductionmentioning

confidence: 99%

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Chemical characterization and reactivity of iron chelator-treated amphibole asbestos.

Gold

Amandusson

Krozer

et al. 1997

Environ Health Perspect

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Iron in amphibole asbestos is implicated in the pathogenicity of inhaled fibers. Evidence includes the observation that iron chelators can suppress fiber-induced tissue damage. This is believed to occur via the diminished production of fiber-associated reactive oxygen species. The purpose of this study was to explore possible mechanisms for the reduction of fiber toxicity by iron chelator treatments. We studied changes in the amount and the oxidation states of bulk and surface iron in crocidolite and amosite asbestos that were treated with iron-chelating desferrioxamine, ferrozine, sodium ascorbate, and phosphate buffer solutions. The results have been compared with the ability of the fibers to produce free radicals and decompose hydrogen peroxide in a cellfree system in vitro. We found that chelators can affect the amount of iron at the surface of the asbestos fibers and its valence, and that they can modify the chemical reactivity of these surfaces. However, we found no obvious or direct correlations between fiber reactivity and the amount of iron removed, the amount of iron at the fiber surface, or the oxidation state of surface iron. Our results suggest that surface Fe3+ ions may play a role in fiber-related carboxylate radical formation, and that desferrioxamine and phosphate groups detected at treated fiber surfaces may play a role in diminishing and enhancing, respectively, fiber redox activity. It is proposed that iron mobility in the silicate structure may play a larger role in the chemical reactivity of asbestos than previously assumed. Environ Health Perspect 1 05(Suppl 5):1 021-1030 (1997)

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Section: Discussionsupporting

confidence: 86%

Section: Iron Assodated With Asbestos Fibers After Chelator Treatmentscontrasting

confidence: 76%

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Chemical characterization and reactivity of iron chelator-treated amphibole asbestos.

Gold

Amandusson

Krozer

et al. 1997

Environ Health Perspect

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“…In addition to the obvious adsorption of biomolecules from extracellular fluids and cytoplasm, some ions will be selectively deposited on the particle and others extracted by endogenous chelators. Iron chelators mobilize considerable amounts of iron from some asbestos, which modifies the surface and subsurface layers (44,50,53,(65)(66)(67). Solubility in biological fluids containing molecules or anions that may chelate metal ions e.g., oxalate, phosphate, cysteine is much different from that in pure aqueous solution (66,67).…”

Section: Modification Of the Surface In Vivomentioning

confidence: 99%

Surface reactivity in the pathogenic response to particulates.

Fubini

1997

Environ Health Perspect

121

100

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The peculiar characteristics of dust toxicity are discussed in relation to the processes taking place at the particle-biological medium interface. Because of surface reactivity, toxicity of solids is not merely predictable from chemical composition and molecular structure, as with water soluble compounds. With particles having the same bulk composition, micromorphology (the thermal and mechanical history of dust and adsorption from the environment) determines the kind and abundance of active surface sites, thus modulating reactivity toward cells and tissues. The quantitative evaluation of doses is discussed in comparisons of dose-response relationships obtained with different materials. Responses related to the surface of the particle are better compared on a per-unit surface than per-unit weight basis. The role of micromorphology, hydrophilicity, and reactive surface cations in determining the pathogenicity of inhaled particles is described with reference to silica and asbestos toxicity. Heating crystalline silica decreases hydrophilicity, with consequent modifications in membranolytic potential, retention, and transport. Transition metal ions exposed at the surface generate free radicals in aqueous suspensions. Continuous redox cycling of iron, with consequent activation-reactivation of the surface sites releasing free radicals, could account for the long-term pathogenicity caused by the inhalation of iron-containing fibers. In various pathogenicities caused by mixed dusts, the contact between components modifies toxicity. Hard metal lung disease is caused by exposure to mixtures of metals and carbides, typically cobalt (Co) and tungsten carbide (WC), but not to single components. Toxicity stems from reactive oxygen species generation in a mechanism involving both Co metal and WC in mutual contact. A relationship between the extent of water adsorption and biopersistence is proposed for vitreous fibers. Modifications of the surface taking place in vivo are described for ferruginous bodies and for the progressive comminution of chrysotile asbestos fibers. Environ Health Perspect 1 05(Suppl 5): 1013-1020 (1997)

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“…Studies have dealt with the toxicological aspects in vivo and/or in vitro and fiber characterization, trying to understand the reasons of fiber "asbestos", with ideal chemical formula K 2 (Na,Ca 0.5 ) 7 [Al 9 Si 27 O 72 ]·28H 2 O) fibers from Oregon (USA) and Karlik (Cappadocia, Turkey) [35]. In the chemical formula of erionite, iron may be present only as impurity, nevertheless the large amount of iron-mineral particles lying on erionite surface may contribute to the carcinogenicity of this mineral defined, as proposed by Hill et al, 1990, for the first time, and by IARC, 2012, more carcinogenic than "asbestos" [40,41].…”

Section: Introductionmentioning

confidence: 99%

Raman Micro-Spectroscopy Identifies Carbonaceous Particles Lying on the Surface of Crocidolite, Amosite, and Chrysotile Fibers

2018

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Micro-Raman spectroscopy has been applied on UICC (Union for International Cancer Control's) crocidolite and amosite from South Africa and on UICC chrysotile from Canada. Under Optical Microscope (OM), the surface of the fibers was often characterized by areas, micrometric in size, appearing dark. The laser beam was successively focused on areas of the same sample showing different optical contrasts. On the bright zones, Raman spectra peculiar for crocidolite, amosite or chrysotile were recorded. When dark areas were optically identified, the laser beam was addressed onto these regions and, in the Raman patterns, in addition to the bands produced by the mineral fiber, bands ascribing to substituted carbonaceous phases were observed. These bands were lying in the 4000-1100 cm −1 spectral range. On the basis of the shape of the bands and their relative intensities, suggestions about the order-disorder of the carbonaceous particles could be proposed, and they appeared more ordered on amosite than on crocidolite and chrysotile. From the exposed data, crocidolite and amosite fibers from South Africa, and chrysotile fibers from Canada, largely used in industry in the past, are characterized by many carbonaceous micrometric particles, lying on the fiber surfaces. Based on the noxiousness of the carbon particles on human health, their presence on asbestos fibers may play a role in increasing the carcinogenic effects of the analyzed fibrous minerals.

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Asbestiform riebeckite (crocidolite) dissolution in the presence of Fe chelators; implications for mineral-induced disease

Cited by 50 publications

References 22 publications

Chemical characterization and reactivity of iron chelator-treated amphibole asbestos.

Chemical characterization and reactivity of iron chelator-treated amphibole asbestos.

Surface reactivity in the pathogenic response to particulates.

Raman Micro-Spectroscopy Identifies Carbonaceous Particles Lying on the Surface of Crocidolite, Amosite, and Chrysotile Fibers

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