ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-κB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer

Fu, Tao; Ji, Ke; Jin, Li; Zhang, Ji; Wu, Xiaojiang; Ji, Xin; Fan, Biao; Jia, Ziyu; Wang, Anqiang; Liu, Jiaen; Bu, Zhaode; Ji, Jiafu

doi:10.1007/s10120-020-01096-y

Cited by 40 publications

(27 citation statements)

References 38 publications

(52 reference statements)

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“…These results suggested that IRL can promote the proliferation and viability in miiuy croaker cell lines. Of interest, our results are in perfect agreement with some reports that low concentrations of LPS can stimulate cell proliferation (38). In summary, these data lncRNA regulates immune responses in fish suggest that IRL serves as a positive modulator in regulating inflammatory responses and cell proliferation and cell viability.…”

Section: Irl Enhances the Host Antibacterial Responsessupporting

confidence: 92%

Long noncoding RNA IRL regulates NF-κB-mediated immune responses through suppression of miR-27c-3p-dependent IRAK4 downregulation in teleost fish

Zheng

Chu

2021

Journal of Biological Chemistry

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Growing pieces of evidence show that the long noncoding RNAs (lncRNAs) as new regulators participate in the regulation of various physiological and pathological processes. The study of lncRNA in lower invertebrates is still unclear compared with that in mammals. Here, we identified a novel lncRNA, termed IRAK4-related lncRNA (IRL), as a key regulator for innate immunity in teleost fish. We find that miR-27c-3p inhibits IRAK4 expression and thus weakens the NF-κB-mediated signaling pathway. Furthermore, the Gram-negative bacterium Vibrio anguillarum and lipopolysaccharide significantly upregulated host lncRNA IRL expression. Results indicate that IRL functions as a competing endogenous RNA for miR-27c-3p to regulate protein abundance of IRAK4; thus, invading microorganisms are eliminated and immune responses are promoted. Our study also demonstrates the regulation mechanism that lncRNA IRL can competitively adsorb miRNA to regulate the miR-27c-3p/IRAK4 axis that is widespread in teleost fish.

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Section: Irl Enhances the Host Antibacterial Responsessupporting

confidence: 92%

Long noncoding RNA IRL regulates NF-κB-mediated immune responses through suppression of miR-27c-3p-dependent IRAK4 downregulation in teleost fish

Zheng

Chu

2021

Journal of Biological Chemistry

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“…Increasing pieces of studies have shown that lncRNA can play a regulatory role as a spongy body adsorbing miRNA and interfere with the host’s immune signaling pathways through the sponge mechanism ( 29 ). We treated miiuy croaker with LPS and SCRV to identify whereas lncRNAs are potentially involved in the regulation of infection, and then the expression of lncRNAs in the spleen tissues of the treated group and the untreated group was analyzed by RNA-seq data.…”

Section: Resultsmentioning

confidence: 99%

“…Many cytoplasmic lncRNAs have been reported to act as ceRNAs by competitively binding miRNAs ( 29 , 31 ). Through the cytoplasm/nucleus fraction assay experiments, we have been able to determine that NARL is mainly distributed in the cytoplasm.…”

Section: Resultsmentioning

confidence: 99%

The long noncoding RNA NARL regulates immune responses via microRNA-mediated NOD1 downregulation in teleost fish

Zheng

Chu

2021

Journal of Biological Chemistry

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Increasing evidence shows that the long noncoding RNA (lncRNA) is a major regulator and participates in the regulation of various physiological and pathological processes, such as cell proliferation, differentiation, metastasis, and apoptosis. Unlike mammals, however, the study of lncRNA in lower invertebrates is just beginning and the extent of lncRNA-mediate regulation remains unclear. Here, we for the first time identify an lncRNA, termed nucleotide oligomerization domain 1 (NOD1) antibacterial and antiviral-related lncRNA (NARL), as a key regulator for innate immunity in teleost fish. We found that NOD1 plays an important role in the antibacterial and antiviral process in fish and that the microRNA miR-217-5p inhibits NOD1 expression and thus weakens the NF-κB and the IRF3-driven signaling pathway. Furthermore, our results indicated that NARL functions as a competing endogenous RNA (ceRNA) for miR-217-5p to regulate protein abundance of NOD1; thus, invading microorganisms are eliminated and immune responses are promoted. Our study also demonstrates the regulation mechanism that lncRNA NARL can competitive adsorption miR-217-5p to regulate the miR-217-5p/NOD1 axis is widespread in teleost fish. Taken together, our results reveal that NARL in fish is a critical positive regulator of innate immune responses to viral and bacterial infection by suppressing a feedback to NOD1-NF-κB/IRF3-mediated signaling.

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“… 14 LncRNA ASB16‑AS1 is upregulated in DDP-resistant GC cells; this lncRNA could phosphorylate TRIM37 to activate the NF‑κB pathway and promote the proliferation, stemness and DDP resistance of GC. 15 LncRNA BCAR4 could regulate the expression of β-catenin by modulating the Wnt signalling pathway and then promote GC cell resistance to DDP. 16 Downregulation of lncRNA CASC2 contributes to DDP resistance in GC by sponging miR-19a.…”

Section: Resultsmentioning

confidence: 99%

Role of Long Non-Coding RNAs in the Chemoresistance of Gastric Cancer: A Systematic Review

Li¹,

Lü²,

Zhou³

et al. 2021

OTT

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Purpose: Accumulating evidence demonstrates that long non-coding RNAs (lncRNAs) play a vital role in the chemoresistance of gastric cancer (GC). The present systematic review summarises the emerging role, potential targets or pathways and regulatory mechanisms of lncRNAs involved in chemoresistance and proposes a number of clinical implications of lncRNAs as novel therapeutic targets for GC. Methods: Studies on lncRNAs involved in the chemoresistance of GC published until July 2020 in the PubMed and Web of Science databases were systematically reviewed and the expression form, role in chemoresistance, targets or pathways, corresponding drugs and potential mechanisms of relevant lncRNAs were summarised in detail. Results: A total of 48 studies were included in this systematic review. Amongst these studies, 32 involved single drug resistance and 16 involved in multidrug resistance (MDR). The 48 studies collected described 38 lncRNAs in the drug-resistant cells of GC, including 33 upregulated and 5 downregulated lncRNAs. Cisplatin (DDP) was the most studied drug and lncRNA MALAT1 was the most studied lncRNA related to the chemoresistance of GC. The potential mechanisms of chemoresistance for lncRNAs in GC mainly included, amongst others, reduction of apoptosis, induction of autophagy, repair of DNA damage, promotion of epithelial-mesenchymal transition (EMT) and regulation of the related signalling pathways. Conclusion:LncRNAs play a vital role in the chemoresistance of GC and are novel therapeutic targets for the disease. Detailed chemoresistance mechanisms, translational studies and clinical trials on lncRNAs in GC are urgently needed.

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ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate NF-κB pathway and promote proliferation, stemness, and cisplatin resistance of gastric cancer

Cited by 40 publications

References 38 publications

Long noncoding RNA IRL regulates NF-κB-mediated immune responses through suppression of miR-27c-3p-dependent IRAK4 downregulation in teleost fish

Long noncoding RNA IRL regulates NF-κB-mediated immune responses through suppression of miR-27c-3p-dependent IRAK4 downregulation in teleost fish

The long noncoding RNA NARL regulates immune responses via microRNA-mediated NOD1 downregulation in teleost fish

Role of Long Non-Coding RNAs in the Chemoresistance of Gastric Cancer: A Systematic Review

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