AS1411-bivalent-cholesterol-anchor equipped with Zinc phthalocyanine enables NK cells derived exosomes to realize effective tumor-tropism photodynamic therapy
Yuchen Qi,
Jie Hao,
Tian Zeng
et al.
Abstract:Benefitting from their outstanding tumor-penetrating ability and cytotoxic proteins and cytokines, natural killer cell-derived exosomes (NEX) show great potential for cell-free tumor immunotherapy. To meet the clinical tumor therapeutic need, engineered NEX are highly required to further enhance their tumor-tropism and anti-tumor abilities. Thus, we firstly proposed a NEX engineering strategy, using a structure of AS1411-bivalent-cholesterol (B-Chol)-anchor equipped with photosensitizer Zinc phthalocyanine (Zn… Show more
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