AsIII Selectively Induces a Disorder-to-Order Transition in the Metalloid Binding Region of the AfArsR Protein
Annamária Tóth,
Kadosa Sajdik,
Béla Gyurcsik
et al.
Abstract:Arsenic is highly toxic and a significant threat to human health, but certain bacteria have developed defense mechanisms initiated by As III binding to As III -sensing proteins of the ArsR family. The transcriptional regulator AfArsR responds to As III and Sb III by coordinating the metalloids with three cysteines, located in a short sequence of the same monomer chain. Here, we characterize the binding of As III and Hg II to a model peptide encompassing this fragment of the protein via solution equilibrium and… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.