As a New Inflammatory Marker for Familial Mediterranean Fever: Neutrophil-to-Lymphocyte Ratio

Abstract

Familial Mediterranean fever (FMF), which is an autosomal recessive disease, is characterised by recurrent febrile episodes in association with peritonitis, pleuritis and arthritis and has ongoing subclinical inflammation during attack-free period. In this study, we aimed to investigate the relationship between FMF with neutrophil-to-lymphocyte ratio (NLR), which is determined in many chronic inflammations as a new potential inflammatory mediator. We included 62 patients and 41 healthy subjects who were similar in terms of age and sex. We found that the NLR values of the patients were significantly higher than those of the control group, and C-reactive protein values were correlated with NLR. Another finding was the NLR values were significantly higher in the FMF patient with M694V mutation than with other mutations. As a result, NLR might be used in the FMF patient as an indicator of the subclinical inflammation, and the FMF patients with M694V mutation should be followed up closely because of increased subclinical inflammation risk.

The Change of Neutrophil Lymphocyte Ratio in Acute Appendicitis

“…Ahsen and co-workers were sad; NLR might be used in the Familial Mediterranean Fever patient as an indicator of the subclinical inflammation [9]. Gunay and colleagues found an doi: 10.5455/medscience.2015.04.8265…”

“…This marker is cheap, readily accessible and can be calculated quite easily. Recently, neutrophil/lymphocyte ratio (NLR) has been shown to reflect inflammatory burden in some acute inflammatory diseases like to AA [8][9][10][11].…”

Mean Platelet Volume in Children with Familial Mediterranean Fever and the Relationship with Attack Status, Colchicine Treatment and Gene Mutation

“…Makay et al (20) reported that there was no significant difference in MPV levels between FMF patients during attack-free period and healthy controls, while significant reduction in MPV levels were detected during attacks in comparison to attack-free period. In addition, free from attack status, Abanonu et al found no significant difference in MPV levels between FMF patients and healthy controls (21).…”

May Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios Indicate Disease Activity in Ankylosing Spondylitis?

“…4,[6][7][8] On the other hand, NLR has been proposed to be a marker to evaluate systemic inflammatory condition in various chronic inflammatory diseases. [10][11][12][13][14][15][16][17] However, the relationship between disease activity in AS and NLR has not been fully demonstrated yet. NLR is also an objective measurement and does not lead to any additional cost to the patients.…”

“…1,9 Leukocyte count and its subtypes are also well-known inflammatory markers in several diseases. 10,11 Recently, neutrophil-lymphocyte ratio (NLR) has been calculated to evaluate inflammation in various chronic inflammatory diseases such as coronary chronic total occlusion, 10 psoriasis, 11 chronic kidney disease, 12 ulcerative colitis, 13 gastric cancer, 14 chronic obstructive pulmonary disease, 15 familial Mediterranean fever, 16 and AS. 17 In addition, mean platelet volume (MPV) was reported to have a predictive value of inflammation in chronic obstructive pulmonary disease, 15 inflammatory bowel disease, 18 rheumatoid arthritis (RA) and AS.…”