Arzneimittelassoziierte Angioödeme

Sachs, B.; Meier, Thomas; Nöthen, Markus M.; Stieber, Christiane; Stingl, Julia C.

doi:10.1007/s00105-017-4119-9

Cited by 9 publications

(7 citation statements)

References 72 publications

(94 reference statements)

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“…With regard to pathophysiology, one can roughly distinguish between histamine-mediated and bradykinin-mediated angioedemas [2,12]. The following section offers a brief discussion of the differences between the clinical phenotypes of histamine-mediated and bradykininmediated angioedemas and the mechanism of interaction with some comedications in relation to the results of our analysis.…”

Section: Reported Smoking Habits Comedications and Clinical Phenotypmentioning

confidence: 99%

“…Histamine is either released from mast cells and/or basophils in context with an allergic, immunoglobuline E (IgE) mediated reaction or via nonimmunological mechanisms [56]. Histamine-mediated reactions typically present with urticaria and pruritus [2,12,57] and respond to antihistamines [57,58]. Bradykinin-mediated angioedema result from an interference in or inbalance of the bradykinin degradation pathway [2,11,12].…”

Section: Reported Smoking Habits Comedications and Clinical Phenotypmentioning

confidence: 99%

“…Histamine-mediated reactions typically present with urticaria and pruritus [2,12,57] and respond to antihistamines [57,58]. Bradykinin-mediated angioedema result from an interference in or inbalance of the bradykinin degradation pathway [2,11,12]. This may occur due to a hereditary defect or through external factors (e.g.…”

Section: Reported Smoking Habits Comedications and Clinical Phenotypmentioning

confidence: 99%

“…Angioedema is a deep dermal, subcutaneous swelling that typically affects the face, lips, tongue, larynx or pharynx [1,2]. It may be life-threatening [1,3,4], especially when the airways are involved.…”

Section: Introductionmentioning

confidence: 99%

“…ACE is the mainly responsible enzyme for the degradation of bradykinin [10]. If other bradykinin degrading enzymes cannot compensate for this inhibition due to functional relevant genetic variants or environmental factors [11][12][13], the bradykinin concentration may rise and favor the development of angioedema [2,[14][15].…”

Section: Introductionmentioning

confidence: 99%

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Angioedemas associated with renin-angiotensin system blocking drugs: Comparative analysis of spontaneous adverse drug reaction reports

et al. 2020

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Introduction Angioedema is a subcutaneous swelling typically affecting the face, larynx or pharynx. It is a known adverse drug reaction (ADR) of ACE inhibitors (ACEi), angiotensin-II-receptor blockers (ARBs) and aliskiren (renin inhibitor). Several studies have reported pathophysiological mechanisms and risk factors of ACEi-associated angioedemas, whereas little is known for ARBs and aliskiren. The aim of the study was to analyze comparatively ACEi versus ARBs and aliskiren angioedema reports contained in the European ADR database EudraVigilance with regard to reported risk factors and clinical phenotypes. Methods All spontaneous angioedema reports received between 01/2010-06/2017 reporting either an ACEi, ARB, or aliskiren as "suspected/interacting" drug were identified using the Standardized MedDRA Query "angioedema (narrow)". In order to perform a comparative analysis, odds ratios (ORs) were calculated for angioedema reports of ACEi (n = 3.194) versus ARBs (n = 687) and aliskiren (n = 162). Results More patients with a history of allergy were included in angioedema reports of ARBs (6.8%) and aliskiren (13.6%) versus ACEi (4.3%). "Urticaria" as an ADR was reported more frequently in angioedema reports of ARBs (18.5%) and aliskiren (9.0%) versus ACEi (5.0%). ACEi-associated angioedemas were more often designated as "life-threatening" compared to ARBs (OR 2.2 [1.6-2.9]) and aliskiren-associated angioedemas (OR 14.2 (3.5-57.4). Concomitant therapy with mTOR inhibitors (OR 4.3 [1.0-17.9]) and fibrinolytics (OR 7.8 [1.1-57.2]) was reported more often in ACEi versus ARBs angioedema reports.

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Section: Reported Smoking Habits Comedications and Clinical Phenotypmentioning

confidence: 99%