Arylsulfatases A and B: From normal tissues to malignant tumors

Kovács, Zsolt; Jung, Ioan; Gurzu, Simona

doi:10.1016/j.prp.2019.152516

Cited by 13 publications

(15 citation statements)

References 47 publications

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“…Arylsulfatases are lysosomal enzymes that are able to catalyze the hydrolysis of sulfate esters. A total deficiency of ARSA is known to induce metabolic disorders such as metachromatic leukodystrophy, a lysosomal storage disorder characterized by the accumulation of cerebroside sulfate within lysosomes and the further destruction of the brain's white matter[3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Chondroitin sulfate and dermatan sulfate are the targets of ARSB, which are glycosaminoglycans. The total deficiency of ARSB leads to Maroteaux-Lamy syndrome, a genetic disorder with severe neurological dysfunction[4,5]. The pseudo-deficiency and/or extralysosomal localization of ARSA and/or ARSB is not known to cause serious health problems[4,6].…”

Section: Introductionmentioning

confidence: 99%

“…In one of the recently published reviews of the literature, we showed that fewer than 40 papers concerning the possible role of ARSA/ARSB in tumorigenesis were published in the English literature and indexed in the Medline database prior to 2018[4]. These studies were mainly based on cell lines and took into account malignant melanoma (about one paper), lung cancer (about two papers), urogenital cancer (about 10 papers) and CRC (about 20 papers)[4]. Independently of carcinoma localization, a decreased expression pattern of ARSA and ARSB was described in the above-mentioned papers[7].…”

Section: Introductionmentioning

confidence: 99%

“…In CRC, it seems that ARSB is expressed in normal colonic mucosa and shows a loss of intensity in tumor cells, with a role in carcinoma invasiveness and metastatic capacity[4,7,8]. To our knowledge, no data about the role of ARSA in CRC have yet been published[4].…”

Section: Introductionmentioning

confidence: 99%

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Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer

Kovács¹,

Jung²,

Szalman³

et al. 2019

WJCC

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BACKGROUNDAlthough it has been shown that arylsulfatases are lost in colorectal cancer (CRC) cell lines, their exact role in the carcinogenesis and behavior of this cancer was not elucidated. No data about the correlation between serum and immunohistochemical (IHC) level of arylsulfatases (ARSA, ARSB) in patients with CRC were published yet.AIMTo evaluate the possible prognostic value of ARSA and/or ARSB in CRC, at circulating and protein levels.METHODSThe present study included 45 consecutive patients who were prospectively diagnosed with CRC. For IHC stains (protein expression) ARSA, ARSB and maspin expression were quantified. For these markers, cytoplasmic expression was taken into account. For gene expression study, circulating mRNA was isolated from all patients, before surgery. A group of 45 healthy patients without inflammatory or tumor pathologies was used as control group. Reverse transcription and Taqman Gene Expression Array were used for ARSB gene expression.RESULTSThe preoperative circulating RNA level of the ARSB gene was significantly decreased in patients with CRC (RQ < 1), compared with the control group (RQ > 1). A more significant decrease (RQ < 0.5) occurred in ulcero-infiltrative maspin-positive adenocarcinomas, with a higher degree of tumor budding, diagnosed in locally advanced stages (pT3/4). ARSA/maspin immunopositivity indicated a higher risk for lymph node metastasis, while triple positivity for maspin/ARSA/ARSB and ARSB gene expression level < 0.5 were indicators of CRC aggressive behavior, independent of lymph node status.CONCLUSIONThe significant independent negative prognostic factors of CRC are the ulcero-infiltrative aspect, high budding degree, triple positivity for maspin, ARSA and ARSB, and low ARSB gene expression.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer

Kovács¹,

Jung²,

Szalman³

et al. 2019

WJCC

Self Cite

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“…For example, ARBS (Arylsulfatases B) is mainly localized in lysosomes which is important roles in the cell metabolism. It is reported that ARBS regarded as a potential biomarker in prostate cancer and melanoma . BAX (BCL‐2 Associated X) is an important modulator of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of autophagy‐related‐gene biomarker and nomogram for predicting the survival of cutaneous melanoma

Wan

Jin

et al. 2020

IUBMB Life

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Autophagy plays a critical role in cutaneous melanoma, but the prognostic research of differentially expressed autophagy‐related genes (DEARGs) in melanoma is lacking. Therefore, autophagy‐related gene expression data of 630 melanoma patients were obtained from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas database. The DEARGs were identified by “limma” package in R software. Best survival analysis and the least absolute shrinkage and selection operator method were performed to identify a robust 7‐DEARG signature as well as construct nomogram associated with the clinical characteristics and validation in internal and external sets. This 7‐DEARG signature could be regarded as an independent prognostic signature in clinical setting, and nomogram may supply a more simple and accurate prediction for the prognosis of melanoma. Moreover, 5 cancer hallmarks and 18 potential compounds are commonly enriched in high‐risk expression phenotype. Thus, our finding provides new clinical evidences for the accurate diagnosis and identifies a potential prognostic autophagy‐related marker for the treatment of melanoma.

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Transcriptome analysis of Manila clam (Ruditapes philippinarum) under Vibrio parahaemolyticus challenge in a low-salinity environment provides molecular insights into immune response

Wang,

Li,

Zhang

et al. 2024

Aquaculture

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Arylsulfatases A and B: From normal tissues to malignant tumors

Cited by 13 publications

References 47 publications

Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer

Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer

Development and validation of autophagy‐related‐gene biomarker and nomogram for predicting the survival of cutaneous melanoma

Transcriptome analysis of Manila clam (Ruditapes philippinarum) under Vibrio parahaemolyticus challenge in a low-salinity environment provides molecular insights into immune response

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